Histopathological Evidence of Occipital Involvement in Male Androgenetic Alopecia

Background: The occipital region of the scalp is generally accepted as an unaffected area of androgenetic alopecia (AGA) for both genders. However, evidence of AGA involving the occipital scalp has been demonstrated in women; meanwhile, it is unclear whether occipital involvement also occurs in men....

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Autores principales:	Saranya Khunkhet, Kumutnart Chanprapaph, Suthinee Rutnin, Poonkiat Suchonwanit
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	pattern hair loss transverse section hair count donor site hair transplantation miniaturization Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2a99617a0459442e84e9198731e1b3a7
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spelling	oai:doaj.org-article:2a99617a0459442e84e9198731e1b3a72021-11-22T04:35:15ZHistopathological Evidence of Occipital Involvement in Male Androgenetic Alopecia2296-858X10.3389/fmed.2021.790597https://doaj.org/article/2a99617a0459442e84e9198731e1b3a72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.790597/fullhttps://doaj.org/toc/2296-858XBackground: The occipital region of the scalp is generally accepted as an unaffected area of androgenetic alopecia (AGA) for both genders. However, evidence of AGA involving the occipital scalp has been demonstrated in women; meanwhile, it is unclear whether occipital involvement also occurs in men.Objective: We aimed to determine if there is occipital involvement in men with AGA.Methods: This case-control study compared hair counts of scalp biopsy specimens from the occipital region of 82 men with Hamilton-Norwood III-VII and 82 unaffected men.Results: The mean ages of men with AGA and controls were 40.1 ± 8.9 and 38.6 ± 10.5 years, respectively (P = 0.291). A significant decrease in total hair follicles, terminal hair follicles, follicular units and terminal to vellus (T:V) ratio, along with a significant increase in follicular stelae was indicated in the AGA group compared to controls (all P < 0.05). Subgroup analyses revealed that average counts of total hair follicles, terminal hair follicles and T:V ratios were also significantly lower in males with Hamilton-Norwood VI and VII than in controls (all P < 0.05). There were no correlations between increasing age and hair count parameters, but a significant negative association was found between total follicle numbers and disease duration (r = −0.23, P = 0.02).Conclusions: AGA can involve the occipital area of male patients with advanced disease. Therefore, the occiput of particular cases should not be used to determine reference data for normal scalp hair, and preoperative measurements of miniaturized hairs in the donor site are strongly recommended in all persons undergoing hair transplantation.Saranya KhunkhetSaranya KhunkhetKumutnart ChanprapaphSuthinee RutninPoonkiat SuchonwanitFrontiers Media S.A.articlepattern hair losstransverse sectionhair countdonor sitehair transplantationminiaturizationMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pattern hair loss transverse section hair count donor site hair transplantation miniaturization Medicine (General) R5-920
spellingShingle	pattern hair loss transverse section hair count donor site hair transplantation miniaturization Medicine (General) R5-920 Saranya Khunkhet Saranya Khunkhet Kumutnart Chanprapaph Suthinee Rutnin Poonkiat Suchonwanit Histopathological Evidence of Occipital Involvement in Male Androgenetic Alopecia
description	Background: The occipital region of the scalp is generally accepted as an unaffected area of androgenetic alopecia (AGA) for both genders. However, evidence of AGA involving the occipital scalp has been demonstrated in women; meanwhile, it is unclear whether occipital involvement also occurs in men.Objective: We aimed to determine if there is occipital involvement in men with AGA.Methods: This case-control study compared hair counts of scalp biopsy specimens from the occipital region of 82 men with Hamilton-Norwood III-VII and 82 unaffected men.Results: The mean ages of men with AGA and controls were 40.1 ± 8.9 and 38.6 ± 10.5 years, respectively (P = 0.291). A significant decrease in total hair follicles, terminal hair follicles, follicular units and terminal to vellus (T:V) ratio, along with a significant increase in follicular stelae was indicated in the AGA group compared to controls (all P < 0.05). Subgroup analyses revealed that average counts of total hair follicles, terminal hair follicles and T:V ratios were also significantly lower in males with Hamilton-Norwood VI and VII than in controls (all P < 0.05). There were no correlations between increasing age and hair count parameters, but a significant negative association was found between total follicle numbers and disease duration (r = −0.23, P = 0.02).Conclusions: AGA can involve the occipital area of male patients with advanced disease. Therefore, the occiput of particular cases should not be used to determine reference data for normal scalp hair, and preoperative measurements of miniaturized hairs in the donor site are strongly recommended in all persons undergoing hair transplantation.
format	article
author	Saranya Khunkhet Saranya Khunkhet Kumutnart Chanprapaph Suthinee Rutnin Poonkiat Suchonwanit
author_facet	Saranya Khunkhet Saranya Khunkhet Kumutnart Chanprapaph Suthinee Rutnin Poonkiat Suchonwanit
author_sort	Saranya Khunkhet
title	Histopathological Evidence of Occipital Involvement in Male Androgenetic Alopecia
title_short	Histopathological Evidence of Occipital Involvement in Male Androgenetic Alopecia
title_full	Histopathological Evidence of Occipital Involvement in Male Androgenetic Alopecia
title_fullStr	Histopathological Evidence of Occipital Involvement in Male Androgenetic Alopecia
title_full_unstemmed	Histopathological Evidence of Occipital Involvement in Male Androgenetic Alopecia
title_sort	histopathological evidence of occipital involvement in male androgenetic alopecia
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2a99617a0459442e84e9198731e1b3a7
work_keys_str_mv	AT saranyakhunkhet histopathologicalevidenceofoccipitalinvolvementinmaleandrogeneticalopecia AT saranyakhunkhet histopathologicalevidenceofoccipitalinvolvementinmaleandrogeneticalopecia AT kumutnartchanprapaph histopathologicalevidenceofoccipitalinvolvementinmaleandrogeneticalopecia AT suthineerutnin histopathologicalevidenceofoccipitalinvolvementinmaleandrogeneticalopecia AT poonkiatsuchonwanit histopathologicalevidenceofoccipitalinvolvementinmaleandrogeneticalopecia
_version_	1718418152211087360

Histopathological Evidence of Occipital Involvement in Male Androgenetic Alopecia

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