From Mosquito Bites to Sexual Transmission: Evaluating Mouse Models of Zika Virus Infection

Following the recent outbreak of Zika virus (ZIKV) infections in Latin America, ZIKV has emerged as a global health threat due to its ability to induce neurological disease in both adults and the developing fetus. ZIKV is largely mosquito-borne and is now endemic in many parts of Africa, Asia, and S...

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Autores principales:	Elizabeth Balint, Amelia Montemarano, Emily Feng, Ali A. Ashkar
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Zika virus mouse model mosquito-borne disease sexually transmitted infections Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/2a9d7cedc57141b3b788e949f664cc1d
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spelling	oai:doaj.org-article:2a9d7cedc57141b3b788e949f664cc1d2021-11-25T19:13:43ZFrom Mosquito Bites to Sexual Transmission: Evaluating Mouse Models of Zika Virus Infection10.3390/v131122441999-4915https://doaj.org/article/2a9d7cedc57141b3b788e949f664cc1d2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2244https://doaj.org/toc/1999-4915Following the recent outbreak of Zika virus (ZIKV) infections in Latin America, ZIKV has emerged as a global health threat due to its ability to induce neurological disease in both adults and the developing fetus. ZIKV is largely mosquito-borne and is now endemic in many parts of Africa, Asia, and South America. However, several reports have demonstrated persistent ZIKV infection of the male reproductive tract and evidence of male-to-female sexual transmission of ZIKV. Sexual transmission may broaden the reach of ZIKV infections beyond its current geographical limits, presenting a significant threat worldwide. Several mouse models of ZIKV infection have been developed to investigate ZIKV pathogenesis and develop effective vaccines and therapeutics. However, the majority of these models focus on mosquito-borne infection, while few have considered the impact of sexual transmission on immunity and pathogenesis. This review will examine the advantages and disadvantages of current models of mosquito-borne and sexually transmitted ZIKV and provide recommendations for the effective use of ZIKV mouse models.Elizabeth BalintAmelia MontemaranoEmily FengAli A. AshkarMDPI AGarticleZika virusmouse modelmosquito-borne diseasesexually transmitted infectionsMicrobiologyQR1-502ENViruses, Vol 13, Iss 2244, p 2244 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Zika virus mouse model mosquito-borne disease sexually transmitted infections Microbiology QR1-502
spellingShingle	Zika virus mouse model mosquito-borne disease sexually transmitted infections Microbiology QR1-502 Elizabeth Balint Amelia Montemarano Emily Feng Ali A. Ashkar From Mosquito Bites to Sexual Transmission: Evaluating Mouse Models of Zika Virus Infection
description	Following the recent outbreak of Zika virus (ZIKV) infections in Latin America, ZIKV has emerged as a global health threat due to its ability to induce neurological disease in both adults and the developing fetus. ZIKV is largely mosquito-borne and is now endemic in many parts of Africa, Asia, and South America. However, several reports have demonstrated persistent ZIKV infection of the male reproductive tract and evidence of male-to-female sexual transmission of ZIKV. Sexual transmission may broaden the reach of ZIKV infections beyond its current geographical limits, presenting a significant threat worldwide. Several mouse models of ZIKV infection have been developed to investigate ZIKV pathogenesis and develop effective vaccines and therapeutics. However, the majority of these models focus on mosquito-borne infection, while few have considered the impact of sexual transmission on immunity and pathogenesis. This review will examine the advantages and disadvantages of current models of mosquito-borne and sexually transmitted ZIKV and provide recommendations for the effective use of ZIKV mouse models.
format	article
author	Elizabeth Balint Amelia Montemarano Emily Feng Ali A. Ashkar
author_facet	Elizabeth Balint Amelia Montemarano Emily Feng Ali A. Ashkar
author_sort	Elizabeth Balint
title	From Mosquito Bites to Sexual Transmission: Evaluating Mouse Models of Zika Virus Infection
title_short	From Mosquito Bites to Sexual Transmission: Evaluating Mouse Models of Zika Virus Infection
title_full	From Mosquito Bites to Sexual Transmission: Evaluating Mouse Models of Zika Virus Infection
title_fullStr	From Mosquito Bites to Sexual Transmission: Evaluating Mouse Models of Zika Virus Infection
title_full_unstemmed	From Mosquito Bites to Sexual Transmission: Evaluating Mouse Models of Zika Virus Infection
title_sort	from mosquito bites to sexual transmission: evaluating mouse models of zika virus infection
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2a9d7cedc57141b3b788e949f664cc1d
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From Mosquito Bites to Sexual Transmission: Evaluating Mouse Models of Zika Virus Infection

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