Infant study of hemispheric asymmetry after long‐gap esophageal atresia repair

Abstract Objectives Previous studies have demonstrated that infants are typically born with a left‐greater‐than‐right forebrain asymmetry that reverses throughout the first year of life. We hypothesized that critically ill term‐born and premature patients following surgical and critical care for lon...

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Autores principales:	Mackenzie S. Kagan, Chandler R. L. Mongerson, David Zurakowski, Russell W. Jennings, Dusica Bajic
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/2aa3a66caff5401ba3d13489c1424f77
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spelling	oai:doaj.org-article:2aa3a66caff5401ba3d13489c1424f772021-11-22T11:11:52ZInfant study of hemispheric asymmetry after long‐gap esophageal atresia repair2328-950310.1002/acn3.51465https://doaj.org/article/2aa3a66caff5401ba3d13489c1424f772021-11-01T00:00:00Zhttps://doi.org/10.1002/acn3.51465https://doaj.org/toc/2328-9503Abstract Objectives Previous studies have demonstrated that infants are typically born with a left‐greater‐than‐right forebrain asymmetry that reverses throughout the first year of life. We hypothesized that critically ill term‐born and premature patients following surgical and critical care for long‐gap esophageal atresia (LGEA) would exhibit alteration in expected forebrain asymmetry. Methods Term‐born (n = 13) and premature (n = 13) patients, and term‐born controls (n = 23) <1 year corrected age underwent non‐sedated research MRI following completion of LGEA treatment via Foker process. Structural T1‐ and T2‐weighted images were collected, and ITK‐SNAP was used for forebrain tissue segmentation and volume acquisition. Data were presented as absolute (cm3) and normalized (% total forebrain) volumes of the hemispheres. All measures were checked for normality, and group status was assessed using a general linear model with age at scan as a covariate. Results Absolute volumes of both forebrain hemispheres were smaller in term‐born and premature patients in comparison to controls (p < 0.001). Normalized hemispheric volume group differences were detected by T1‐weighted analysis, with premature patients demonstrating right‐greater‐than‐left hemisphere volumes in comparison to term‐born patients and controls (p < 0.01). While normalized group differences were very subtle (a right hemispheric predominance of roughly 2% of forebrain volume), they represent a deviation from the expected pattern of hemispheric brain asymmetry. Interpretation Our pilot quantitative MRI study of hemispheric volumes suggests that premature patients might be at risk of altered expected left‐greater‐than‐right forebrain asymmetry following repair of LGEA. Future neurobehavioral studies in infants born with LGEA are needed to elucidate the functional significance of presented anatomical findings.Mackenzie S. KaganChandler R. L. MongersonDavid ZurakowskiRussell W. JenningsDusica BajicWileyarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENAnnals of Clinical and Translational Neurology, Vol 8, Iss 11, Pp 2132-2145 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Mackenzie S. Kagan Chandler R. L. Mongerson David Zurakowski Russell W. Jennings Dusica Bajic Infant study of hemispheric asymmetry after long‐gap esophageal atresia repair
description	Abstract Objectives Previous studies have demonstrated that infants are typically born with a left‐greater‐than‐right forebrain asymmetry that reverses throughout the first year of life. We hypothesized that critically ill term‐born and premature patients following surgical and critical care for long‐gap esophageal atresia (LGEA) would exhibit alteration in expected forebrain asymmetry. Methods Term‐born (n = 13) and premature (n = 13) patients, and term‐born controls (n = 23) <1 year corrected age underwent non‐sedated research MRI following completion of LGEA treatment via Foker process. Structural T1‐ and T2‐weighted images were collected, and ITK‐SNAP was used for forebrain tissue segmentation and volume acquisition. Data were presented as absolute (cm3) and normalized (% total forebrain) volumes of the hemispheres. All measures were checked for normality, and group status was assessed using a general linear model with age at scan as a covariate. Results Absolute volumes of both forebrain hemispheres were smaller in term‐born and premature patients in comparison to controls (p < 0.001). Normalized hemispheric volume group differences were detected by T1‐weighted analysis, with premature patients demonstrating right‐greater‐than‐left hemisphere volumes in comparison to term‐born patients and controls (p < 0.01). While normalized group differences were very subtle (a right hemispheric predominance of roughly 2% of forebrain volume), they represent a deviation from the expected pattern of hemispheric brain asymmetry. Interpretation Our pilot quantitative MRI study of hemispheric volumes suggests that premature patients might be at risk of altered expected left‐greater‐than‐right forebrain asymmetry following repair of LGEA. Future neurobehavioral studies in infants born with LGEA are needed to elucidate the functional significance of presented anatomical findings.
format	article
author	Mackenzie S. Kagan Chandler R. L. Mongerson David Zurakowski Russell W. Jennings Dusica Bajic
author_facet	Mackenzie S. Kagan Chandler R. L. Mongerson David Zurakowski Russell W. Jennings Dusica Bajic
author_sort	Mackenzie S. Kagan
title	Infant study of hemispheric asymmetry after long‐gap esophageal atresia repair
title_short	Infant study of hemispheric asymmetry after long‐gap esophageal atresia repair
title_full	Infant study of hemispheric asymmetry after long‐gap esophageal atresia repair
title_fullStr	Infant study of hemispheric asymmetry after long‐gap esophageal atresia repair
title_full_unstemmed	Infant study of hemispheric asymmetry after long‐gap esophageal atresia repair
title_sort	infant study of hemispheric asymmetry after long‐gap esophageal atresia repair
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/2aa3a66caff5401ba3d13489c1424f77
work_keys_str_mv	AT mackenzieskagan infantstudyofhemisphericasymmetryafterlonggapesophagealatresiarepair AT chandlerrlmongerson infantstudyofhemisphericasymmetryafterlonggapesophagealatresiarepair AT davidzurakowski infantstudyofhemisphericasymmetryafterlonggapesophagealatresiarepair AT russellwjennings infantstudyofhemisphericasymmetryafterlonggapesophagealatresiarepair AT dusicabajic infantstudyofhemisphericasymmetryafterlonggapesophagealatresiarepair
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Infant study of hemispheric asymmetry after long‐gap esophageal atresia repair

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