Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

Polymeric hydrogels are widely explored materials for biomedical applications. However, they have inherent limitations like poor resistance to stimuli and low mechanical strength. This drawback of hydrogels gave rise to ‘‘smart self-healing hydrogels’’ which autonomously repair themselves when ruptu...

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Autores principales:	Anupama Devi V. K., Rohin Shyam, Arunkumar Palaniappan, Amit Kumar Jaiswal, Tae-Hwan Oh, Arputharaj Joseph Nathanael
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	self-healing dynamic bonds hydrogels wound healing drug delivery cell delivery Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/2aa664cf7dc5480b955af90753ba7a58
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spelling	oai:doaj.org-article:2aa664cf7dc5480b955af90753ba7a582021-11-11T18:47:19ZSelf-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications10.3390/polym132137822073-4360https://doaj.org/article/2aa664cf7dc5480b955af90753ba7a582021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/21/3782https://doaj.org/toc/2073-4360Polymeric hydrogels are widely explored materials for biomedical applications. However, they have inherent limitations like poor resistance to stimuli and low mechanical strength. This drawback of hydrogels gave rise to ‘‘smart self-healing hydrogels’’ which autonomously repair themselves when ruptured or traumatized. It is superior in terms of durability and stability due to its capacity to reform its shape, injectability, and stretchability thereby regaining back the original mechanical property. This review focuses on various self-healing mechanisms (covalent and non-covalent interactions) of these hydrogels, methods used to evaluate their self-healing properties, and their applications in wound healing, drug delivery, cell encapsulation, and tissue engineering systems. Furthermore, composite materials are used to enhance the hydrogel’s mechanical properties. Hence, findings of research with various composite materials are briefly discussed in order to emphasize the healing capacity of such hydrogels. Additionally, various methods to evaluate the self-healing properties of hydrogels and their recent advancements towards 3D bioprinting are also reviewed. The review is concluded by proposing several pertinent challenges encountered at present as well as some prominent future perspectives.Anupama Devi V. K.Rohin ShyamArunkumar PalaniappanAmit Kumar JaiswalTae-Hwan OhArputharaj Joseph NathanaelMDPI AGarticleself-healingdynamic bondshydrogelswound healingdrug deliverycell deliveryOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3782, p 3782 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	self-healing dynamic bonds hydrogels wound healing drug delivery cell delivery Organic chemistry QD241-441
spellingShingle	self-healing dynamic bonds hydrogels wound healing drug delivery cell delivery Organic chemistry QD241-441 Anupama Devi V. K. Rohin Shyam Arunkumar Palaniappan Amit Kumar Jaiswal Tae-Hwan Oh Arputharaj Joseph Nathanael Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications
description	Polymeric hydrogels are widely explored materials for biomedical applications. However, they have inherent limitations like poor resistance to stimuli and low mechanical strength. This drawback of hydrogels gave rise to ‘‘smart self-healing hydrogels’’ which autonomously repair themselves when ruptured or traumatized. It is superior in terms of durability and stability due to its capacity to reform its shape, injectability, and stretchability thereby regaining back the original mechanical property. This review focuses on various self-healing mechanisms (covalent and non-covalent interactions) of these hydrogels, methods used to evaluate their self-healing properties, and their applications in wound healing, drug delivery, cell encapsulation, and tissue engineering systems. Furthermore, composite materials are used to enhance the hydrogel’s mechanical properties. Hence, findings of research with various composite materials are briefly discussed in order to emphasize the healing capacity of such hydrogels. Additionally, various methods to evaluate the self-healing properties of hydrogels and their recent advancements towards 3D bioprinting are also reviewed. The review is concluded by proposing several pertinent challenges encountered at present as well as some prominent future perspectives.
format	article
author	Anupama Devi V. K. Rohin Shyam Arunkumar Palaniappan Amit Kumar Jaiswal Tae-Hwan Oh Arputharaj Joseph Nathanael
author_facet	Anupama Devi V. K. Rohin Shyam Arunkumar Palaniappan Amit Kumar Jaiswal Tae-Hwan Oh Arputharaj Joseph Nathanael
author_sort	Anupama Devi V. K.
title	Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications
title_short	Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications
title_full	Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications
title_fullStr	Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications
title_full_unstemmed	Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications
title_sort	self-healing hydrogels: preparation, mechanism and advancement in biomedical applications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2aa664cf7dc5480b955af90753ba7a58
work_keys_str_mv	AT anupamadevivk selfhealinghydrogelspreparationmechanismandadvancementinbiomedicalapplications AT rohinshyam selfhealinghydrogelspreparationmechanismandadvancementinbiomedicalapplications AT arunkumarpalaniappan selfhealinghydrogelspreparationmechanismandadvancementinbiomedicalapplications AT amitkumarjaiswal selfhealinghydrogelspreparationmechanismandadvancementinbiomedicalapplications AT taehwanoh selfhealinghydrogelspreparationmechanismandadvancementinbiomedicalapplications AT arputharajjosephnathanael selfhealinghydrogelspreparationmechanismandadvancementinbiomedicalapplications
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Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

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