Effects of mediastinal lymph node dissection in colorectal cancer‐related pulmonary metastasectomy

Abstract Background The benefits of mediastinal lymph node dissection (MLND) in colorectal cancer‐related pulmonary metastasectomy (PM) have been poorly reported. This study aimed to determine whether MLND affects survival in patients undergoing PM and to identify the prognostic factors for survival...

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Autores principales:	Young Ho Yang, Seong Yong Park, Ha Eun Kim, Byung Jo Park, Chang Young Lee, Jin Gu Lee, Dae Joon Kim, Hyo Chae Paik
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	colorectal cancer mediastinal lymph node dissection overall survival pulmonary metastasectomy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/2aa8ea059e3247bcb156fd5f2f6e0dc4
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spelling	oai:doaj.org-article:2aa8ea059e3247bcb156fd5f2f6e0dc42021-12-02T02:34:55ZEffects of mediastinal lymph node dissection in colorectal cancer‐related pulmonary metastasectomy1759-77141759-770610.1111/1759-7714.14196https://doaj.org/article/2aa8ea059e3247bcb156fd5f2f6e0dc42021-12-01T00:00:00Zhttps://doi.org/10.1111/1759-7714.14196https://doaj.org/toc/1759-7706https://doaj.org/toc/1759-7714Abstract Background The benefits of mediastinal lymph node dissection (MLND) in colorectal cancer‐related pulmonary metastasectomy (PM) have been poorly reported. This study aimed to determine whether MLND affects survival in patients undergoing PM and to identify the prognostic factors for survival. Methods We retrospectively reviewed 275 patients who had undergone colorectal cancer‐related PM from January 2010 to December 2016. MLND was defined as the resection of at least six mediastinal lymph node stations according to the International Association for the Study of Lung Cancer criteria (N1, ≥3 stations; N2, ≥3 stations). The propensity score matching method was used to reduce bias. Results Thirty‐three (12%) patients underwent MLND, and 13 (4.7%) patients had mediastinal lymph node involvement. This study showed no difference in 5‐year overall survival (no MLND, 52.7% vs. MLND, 53.5%; p = 0.81). On multivariable analysis, negative prognostic factors for overall survival were preoperative carcinoembryonic antigen (CEA) level (p < 0.001), a higher number of metastatic nodules (p < 0.001), metastatic nodule size ≥2 cm (p < 0.001), and lymph node involvement (p = 0.006). Conclusions Mediastinal lymph node involvement, preoperative CEA level, higher metastatic nodule number, and nodule size negatively affected survival whereas MLND in PM was not associated with survival.Young Ho YangSeong Yong ParkHa Eun KimByung Jo ParkChang Young LeeJin Gu LeeDae Joon KimHyo Chae PaikWileyarticlecolorectal cancermediastinal lymph node dissectionoverall survivalpulmonary metastasectomyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENThoracic Cancer, Vol 12, Iss 23, Pp 3248-3254 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer mediastinal lymph node dissection overall survival pulmonary metastasectomy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	colorectal cancer mediastinal lymph node dissection overall survival pulmonary metastasectomy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Young Ho Yang Seong Yong Park Ha Eun Kim Byung Jo Park Chang Young Lee Jin Gu Lee Dae Joon Kim Hyo Chae Paik Effects of mediastinal lymph node dissection in colorectal cancer‐related pulmonary metastasectomy
description	Abstract Background The benefits of mediastinal lymph node dissection (MLND) in colorectal cancer‐related pulmonary metastasectomy (PM) have been poorly reported. This study aimed to determine whether MLND affects survival in patients undergoing PM and to identify the prognostic factors for survival. Methods We retrospectively reviewed 275 patients who had undergone colorectal cancer‐related PM from January 2010 to December 2016. MLND was defined as the resection of at least six mediastinal lymph node stations according to the International Association for the Study of Lung Cancer criteria (N1, ≥3 stations; N2, ≥3 stations). The propensity score matching method was used to reduce bias. Results Thirty‐three (12%) patients underwent MLND, and 13 (4.7%) patients had mediastinal lymph node involvement. This study showed no difference in 5‐year overall survival (no MLND, 52.7% vs. MLND, 53.5%; p = 0.81). On multivariable analysis, negative prognostic factors for overall survival were preoperative carcinoembryonic antigen (CEA) level (p < 0.001), a higher number of metastatic nodules (p < 0.001), metastatic nodule size ≥2 cm (p < 0.001), and lymph node involvement (p = 0.006). Conclusions Mediastinal lymph node involvement, preoperative CEA level, higher metastatic nodule number, and nodule size negatively affected survival whereas MLND in PM was not associated with survival.
format	article
author	Young Ho Yang Seong Yong Park Ha Eun Kim Byung Jo Park Chang Young Lee Jin Gu Lee Dae Joon Kim Hyo Chae Paik
author_facet	Young Ho Yang Seong Yong Park Ha Eun Kim Byung Jo Park Chang Young Lee Jin Gu Lee Dae Joon Kim Hyo Chae Paik
author_sort	Young Ho Yang
title	Effects of mediastinal lymph node dissection in colorectal cancer‐related pulmonary metastasectomy
title_short	Effects of mediastinal lymph node dissection in colorectal cancer‐related pulmonary metastasectomy
title_full	Effects of mediastinal lymph node dissection in colorectal cancer‐related pulmonary metastasectomy
title_fullStr	Effects of mediastinal lymph node dissection in colorectal cancer‐related pulmonary metastasectomy
title_full_unstemmed	Effects of mediastinal lymph node dissection in colorectal cancer‐related pulmonary metastasectomy
title_sort	effects of mediastinal lymph node dissection in colorectal cancer‐related pulmonary metastasectomy
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/2aa8ea059e3247bcb156fd5f2f6e0dc4
work_keys_str_mv	AT younghoyang effectsofmediastinallymphnodedissectionincolorectalcancerrelatedpulmonarymetastasectomy AT seongyongpark effectsofmediastinallymphnodedissectionincolorectalcancerrelatedpulmonarymetastasectomy AT haeunkim effectsofmediastinallymphnodedissectionincolorectalcancerrelatedpulmonarymetastasectomy AT byungjopark effectsofmediastinallymphnodedissectionincolorectalcancerrelatedpulmonarymetastasectomy AT changyounglee effectsofmediastinallymphnodedissectionincolorectalcancerrelatedpulmonarymetastasectomy AT jingulee effectsofmediastinallymphnodedissectionincolorectalcancerrelatedpulmonarymetastasectomy AT daejoonkim effectsofmediastinallymphnodedissectionincolorectalcancerrelatedpulmonarymetastasectomy AT hyochaepaik effectsofmediastinallymphnodedissectionincolorectalcancerrelatedpulmonarymetastasectomy
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Effects of mediastinal lymph node dissection in colorectal cancer‐related pulmonary metastasectomy

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