Prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in wastewater: a systematic review and meta-analysis

Wastewater is considered a hotspot niche of multi-drug and pathogenic bacteria such as Enterobacteriaceae-producing extended-spectrum beta-lactamases (ESBL-E). Thus, the aim of this meta-analysis was to evaluate the prevalence of ESBL-E in different wastewater sources. Different databases (Medline,...

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Autores principales:	Nawel Zaatout, Samia Bouras, Nouria Slimani
Formato:	article
Lenguaje:	EN
Publicado:	IWA Publishing 2021
Materias:	β-lactamases blactx-m enterobacteriaceae esbl wastewater Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/2aacd466090843e5a51563e066a0e8db
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spelling	oai:doaj.org-article:2aacd466090843e5a51563e066a0e8db2021-11-06T06:30:43ZPrevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in wastewater: a systematic review and meta-analysis1477-89201996-782910.2166/wh.2021.112https://doaj.org/article/2aacd466090843e5a51563e066a0e8db2021-10-01T00:00:00Zhttp://jwh.iwaponline.com/content/19/5/705https://doaj.org/toc/1477-8920https://doaj.org/toc/1996-7829Wastewater is considered a hotspot niche of multi-drug and pathogenic bacteria such as Enterobacteriaceae-producing extended-spectrum beta-lactamases (ESBL-E). Thus, the aim of this meta-analysis was to evaluate the prevalence of ESBL-E in different wastewater sources. Different databases (Medline, EMBASE, and Cochrane Library) were searched from inception to March 2021. Data were analyzed using random-effects modeling, and subgroup and meta-regression analyses were used to ascertain heterogeneity among the subgroups. Fifty-seven observational studies were selected, and the pooled prevalence of ESBL-E in wastewater was 24.81% (95% CI, 19.28–30.77). Escherichia coli had the highest ESBL prevalence. The blaCTX-M genes were the most prevalent in the selected studies (66.56%). The pooled prevalence of ESBL was significantly higher in reports from America (39.91%, 95% CI, 21.82–59.51) and reports studying hospital and untreated wastewaters (33.98%, 95% CI, 23.82–44.91 and 27.36%, 95% CI, 19.12–36.42). Overall, this meta-analysis showed that the prevalence of ESBL-E in wastewater is increasing over time and that hospital wastewater is the most important repository of ESBL-E. Therefore, there is a need for developing new sewage treatment systems that decrease the introduction of resistant bacteria and antibiotic residues. HIGHLIGHTS The global prevalence of Enterobacteriaceae-producing extended-spectrum beta-lactamases (ESBL-E) in wastewater was found to be 24.81%.; The pooled prevalence of ESBL-E was significantly higher in reports studying hospital wastewater.; The highest prevalence of ESBL-E was in America, and the lowest prevalence was in Europe.; Among ESBL genes, blaCTX-M genes had the highest prevalence, followed by blaTEM and blaSHV.;Nawel ZaatoutSamia BourasNouria SlimaniIWA Publishingarticleβ-lactamasesblactx-menterobacteriaceaeesblwastewaterPublic aspects of medicineRA1-1270ENJournal of Water and Health, Vol 19, Iss 5, Pp 705-723 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	β-lactamases blactx-m enterobacteriaceae esbl wastewater Public aspects of medicine RA1-1270
spellingShingle	β-lactamases blactx-m enterobacteriaceae esbl wastewater Public aspects of medicine RA1-1270 Nawel Zaatout Samia Bouras Nouria Slimani Prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in wastewater: a systematic review and meta-analysis
description	Wastewater is considered a hotspot niche of multi-drug and pathogenic bacteria such as Enterobacteriaceae-producing extended-spectrum beta-lactamases (ESBL-E). Thus, the aim of this meta-analysis was to evaluate the prevalence of ESBL-E in different wastewater sources. Different databases (Medline, EMBASE, and Cochrane Library) were searched from inception to March 2021. Data were analyzed using random-effects modeling, and subgroup and meta-regression analyses were used to ascertain heterogeneity among the subgroups. Fifty-seven observational studies were selected, and the pooled prevalence of ESBL-E in wastewater was 24.81% (95% CI, 19.28–30.77). Escherichia coli had the highest ESBL prevalence. The blaCTX-M genes were the most prevalent in the selected studies (66.56%). The pooled prevalence of ESBL was significantly higher in reports from America (39.91%, 95% CI, 21.82–59.51) and reports studying hospital and untreated wastewaters (33.98%, 95% CI, 23.82–44.91 and 27.36%, 95% CI, 19.12–36.42). Overall, this meta-analysis showed that the prevalence of ESBL-E in wastewater is increasing over time and that hospital wastewater is the most important repository of ESBL-E. Therefore, there is a need for developing new sewage treatment systems that decrease the introduction of resistant bacteria and antibiotic residues. HIGHLIGHTS The global prevalence of Enterobacteriaceae-producing extended-spectrum beta-lactamases (ESBL-E) in wastewater was found to be 24.81%.; The pooled prevalence of ESBL-E was significantly higher in reports studying hospital wastewater.; The highest prevalence of ESBL-E was in America, and the lowest prevalence was in Europe.; Among ESBL genes, blaCTX-M genes had the highest prevalence, followed by blaTEM and blaSHV.;
format	article
author	Nawel Zaatout Samia Bouras Nouria Slimani
author_facet	Nawel Zaatout Samia Bouras Nouria Slimani
author_sort	Nawel Zaatout
title	Prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in wastewater: a systematic review and meta-analysis
title_short	Prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in wastewater: a systematic review and meta-analysis
title_full	Prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in wastewater: a systematic review and meta-analysis
title_fullStr	Prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in wastewater: a systematic review and meta-analysis
title_full_unstemmed	Prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in wastewater: a systematic review and meta-analysis
title_sort	prevalence of extended-spectrum β-lactamase (esbl)-producing enterobacteriaceae in wastewater: a systematic review and meta-analysis
publisher	IWA Publishing
publishDate	2021
url	https://doaj.org/article/2aacd466090843e5a51563e066a0e8db
work_keys_str_mv	AT nawelzaatout prevalenceofextendedspectrumblactamaseesblproducingenterobacteriaceaeinwastewaterasystematicreviewandmetaanalysis AT samiabouras prevalenceofextendedspectrumblactamaseesblproducingenterobacteriaceaeinwastewaterasystematicreviewandmetaanalysis AT nouriaslimani prevalenceofextendedspectrumblactamaseesblproducingenterobacteriaceaeinwastewaterasystematicreviewandmetaanalysis
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Prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in wastewater: a systematic review and meta-analysis

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