Female Nur77-deficient mice show increased susceptibility to diet-induced obesity.

Adipose tissue is essential in the regulation of body weight. The key process in fat catabolism and the provision of energy substrate during times of nutrient deprivation or enhanced energy demand is the hydrolysis of triglycerides and the release of fatty acids and glycerol. Nur77 is a member of th...

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Autores principales:	Sonia Perez-Sieira, Gloria Martinez, Begoña Porteiro, Miguel Lopez, Anxo Vidal, Ruben Nogueiras, Carlos Dieguez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2aacfa063944422f92ec5655e9b2c234
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spelling	oai:doaj.org-article:2aacfa063944422f92ec5655e9b2c2342021-11-18T08:01:35ZFemale Nur77-deficient mice show increased susceptibility to diet-induced obesity.1932-620310.1371/journal.pone.0053836https://doaj.org/article/2aacfa063944422f92ec5655e9b2c2342013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23342015/?tool=EBIhttps://doaj.org/toc/1932-6203Adipose tissue is essential in the regulation of body weight. The key process in fat catabolism and the provision of energy substrate during times of nutrient deprivation or enhanced energy demand is the hydrolysis of triglycerides and the release of fatty acids and glycerol. Nur77 is a member of the NR4A subfamily of nuclear receptors that plays an important metabolic role, modulating hepatic glucose metabolism and lipolysis in muscle. However, its endogenous role on white adipose tissue, as well as the gender dependency of these mechanisms, remains largely unknown. Male and female wild type and Nur77 deficient mice were fed with a high fat diet (45% calories from fat) for 4 months. Mice were analyzed in vivo with the indirect calorimetry system, and tissues were analyzed by real-time PCR and Western blot analysis. Female, but not male Nur77 deficient mice, gained more weight and fat mass when compared to wild type mice fed with high fat diet, which can be explained by decreased energy expenditure. The lack of Nur77 also led to a decreased pHSL/HSL ratio in white adipose tissue and increased expression of CIDEA in brown adipose tissue of female Nur77 deficient mice. Overall, these findings suggest that Nur77 is an important physiological modulator of lipid metabolism in adipose tissue and that there are gender differences in the sensitivity to deletion of the Nur77 signaling. The decreased energy expenditure and the actions of Nur77 on liver, muscle, brown and white adipose tissue contribute to the increased susceptibility to diet-induced obesity in females lacking Nur77.Sonia Perez-SieiraGloria MartinezBegoña PorteiroMiguel LopezAnxo VidalRuben NogueirasCarlos DieguezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e53836 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sonia Perez-Sieira Gloria Martinez Begoña Porteiro Miguel Lopez Anxo Vidal Ruben Nogueiras Carlos Dieguez Female Nur77-deficient mice show increased susceptibility to diet-induced obesity.
description	Adipose tissue is essential in the regulation of body weight. The key process in fat catabolism and the provision of energy substrate during times of nutrient deprivation or enhanced energy demand is the hydrolysis of triglycerides and the release of fatty acids and glycerol. Nur77 is a member of the NR4A subfamily of nuclear receptors that plays an important metabolic role, modulating hepatic glucose metabolism and lipolysis in muscle. However, its endogenous role on white adipose tissue, as well as the gender dependency of these mechanisms, remains largely unknown. Male and female wild type and Nur77 deficient mice were fed with a high fat diet (45% calories from fat) for 4 months. Mice were analyzed in vivo with the indirect calorimetry system, and tissues were analyzed by real-time PCR and Western blot analysis. Female, but not male Nur77 deficient mice, gained more weight and fat mass when compared to wild type mice fed with high fat diet, which can be explained by decreased energy expenditure. The lack of Nur77 also led to a decreased pHSL/HSL ratio in white adipose tissue and increased expression of CIDEA in brown adipose tissue of female Nur77 deficient mice. Overall, these findings suggest that Nur77 is an important physiological modulator of lipid metabolism in adipose tissue and that there are gender differences in the sensitivity to deletion of the Nur77 signaling. The decreased energy expenditure and the actions of Nur77 on liver, muscle, brown and white adipose tissue contribute to the increased susceptibility to diet-induced obesity in females lacking Nur77.
format	article
author	Sonia Perez-Sieira Gloria Martinez Begoña Porteiro Miguel Lopez Anxo Vidal Ruben Nogueiras Carlos Dieguez
author_facet	Sonia Perez-Sieira Gloria Martinez Begoña Porteiro Miguel Lopez Anxo Vidal Ruben Nogueiras Carlos Dieguez
author_sort	Sonia Perez-Sieira
title	Female Nur77-deficient mice show increased susceptibility to diet-induced obesity.
title_short	Female Nur77-deficient mice show increased susceptibility to diet-induced obesity.
title_full	Female Nur77-deficient mice show increased susceptibility to diet-induced obesity.
title_fullStr	Female Nur77-deficient mice show increased susceptibility to diet-induced obesity.
title_full_unstemmed	Female Nur77-deficient mice show increased susceptibility to diet-induced obesity.
title_sort	female nur77-deficient mice show increased susceptibility to diet-induced obesity.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/2aacfa063944422f92ec5655e9b2c234
work_keys_str_mv	AT soniaperezsieira femalenur77deficientmiceshowincreasedsusceptibilitytodietinducedobesity AT gloriamartinez femalenur77deficientmiceshowincreasedsusceptibilitytodietinducedobesity AT begonaporteiro femalenur77deficientmiceshowincreasedsusceptibilitytodietinducedobesity AT miguellopez femalenur77deficientmiceshowincreasedsusceptibilitytodietinducedobesity AT anxovidal femalenur77deficientmiceshowincreasedsusceptibilitytodietinducedobesity AT rubennogueiras femalenur77deficientmiceshowincreasedsusceptibilitytodietinducedobesity AT carlosdieguez femalenur77deficientmiceshowincreasedsusceptibilitytodietinducedobesity
_version_	1718422594276818944

Female Nur77-deficient mice show increased susceptibility to diet-induced obesity.

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