Conception and bicentric validation of the proSCANNED score, a simplified bedside prognostic score for Heart Failure patients
Abstract A simple and accurate prognostic tool for Heart Failure (HF) patients is critical to improve follow-up. Different risk scores are accurate but with limited clinical applicability. The current study aims to derive and validate a simple predictive tool for HF prognosis. French outpatients wit...
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2021
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oai:doaj.org-article:2aad58ce03434967804adb2ae6f069672021-12-02T11:39:43ZConception and bicentric validation of the proSCANNED score, a simplified bedside prognostic score for Heart Failure patients10.1038/s41598-021-85767-52045-2322https://doaj.org/article/2aad58ce03434967804adb2ae6f069672021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85767-5https://doaj.org/toc/2045-2322Abstract A simple and accurate prognostic tool for Heart Failure (HF) patients is critical to improve follow-up. Different risk scores are accurate but with limited clinical applicability. The current study aims to derive and validate a simple predictive tool for HF prognosis. French outpatients with stable HF of two university hospitals were included in the derivation (N = 134) or in the validation (N = 274) sample and followed up for a median of 23 months. Potential predictors were variables with known association with mortality and easily available. The proSCANNED risk score was derived using a parametric survival model on complete case data; it includes 8 binary variables and its values are 0–8. In the validation sample, the ability of the score to discriminate the 1-year vital status was moderate (AUC = 0.71, IC95% = [0.64–0.71]). However, the stratification of the score in three groups showed a good calibration for patients in the low- and medium-risk risk group. The proSCANNED score is an easy-to-use tool in clinical practice with a good discrimination, stability, and calibration sufficient to improve the medical care of patients. Other follow up studies are necessary to assess score applicability in larger populations, and its impact.Claire DuflosKamila SoleckiMichel GalinierRomain ItierJerome RoncalliAnne-Laure GogerBara MandoraahEran KalmanovichFabien HuetAudrey AgulloDelphine DelsenyJean-Christophe MaciaFlorence LeclercqGregoire MercierFrançois RoubilleNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q Claire Duflos Kamila Solecki Michel Galinier Romain Itier Jerome Roncalli Anne-Laure Goger Bara Mandoraah Eran Kalmanovich Fabien Huet Audrey Agullo Delphine Delseny Jean-Christophe Macia Florence Leclercq Gregoire Mercier François Roubille Conception and bicentric validation of the proSCANNED score, a simplified bedside prognostic score for Heart Failure patients |
| description |
Abstract A simple and accurate prognostic tool for Heart Failure (HF) patients is critical to improve follow-up. Different risk scores are accurate but with limited clinical applicability. The current study aims to derive and validate a simple predictive tool for HF prognosis. French outpatients with stable HF of two university hospitals were included in the derivation (N = 134) or in the validation (N = 274) sample and followed up for a median of 23 months. Potential predictors were variables with known association with mortality and easily available. The proSCANNED risk score was derived using a parametric survival model on complete case data; it includes 8 binary variables and its values are 0–8. In the validation sample, the ability of the score to discriminate the 1-year vital status was moderate (AUC = 0.71, IC95% = [0.64–0.71]). However, the stratification of the score in three groups showed a good calibration for patients in the low- and medium-risk risk group. The proSCANNED score is an easy-to-use tool in clinical practice with a good discrimination, stability, and calibration sufficient to improve the medical care of patients. Other follow up studies are necessary to assess score applicability in larger populations, and its impact. |
| format |
article |
| author |
Claire Duflos Kamila Solecki Michel Galinier Romain Itier Jerome Roncalli Anne-Laure Goger Bara Mandoraah Eran Kalmanovich Fabien Huet Audrey Agullo Delphine Delseny Jean-Christophe Macia Florence Leclercq Gregoire Mercier François Roubille |
| author_facet |
Claire Duflos Kamila Solecki Michel Galinier Romain Itier Jerome Roncalli Anne-Laure Goger Bara Mandoraah Eran Kalmanovich Fabien Huet Audrey Agullo Delphine Delseny Jean-Christophe Macia Florence Leclercq Gregoire Mercier François Roubille |
| author_sort |
Claire Duflos |
| title |
Conception and bicentric validation of the proSCANNED score, a simplified bedside prognostic score for Heart Failure patients |
| title_short |
Conception and bicentric validation of the proSCANNED score, a simplified bedside prognostic score for Heart Failure patients |
| title_full |
Conception and bicentric validation of the proSCANNED score, a simplified bedside prognostic score for Heart Failure patients |
| title_fullStr |
Conception and bicentric validation of the proSCANNED score, a simplified bedside prognostic score for Heart Failure patients |
| title_full_unstemmed |
Conception and bicentric validation of the proSCANNED score, a simplified bedside prognostic score for Heart Failure patients |
| title_sort |
conception and bicentric validation of the proscanned score, a simplified bedside prognostic score for heart failure patients |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/2aad58ce03434967804adb2ae6f06967 |
| work_keys_str_mv |
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