Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb

Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb

Reperfusion injury following myocardial ischemia is aggravated by inflammation and platelet–neutrophil complex formation. Here the authors show that semaphorin 7A binds to platelet GPIb, enhancing platelet–neutrophil interaction and increasing post-ischemic myocardial tissue injury, and that blockag...

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Autores principales: David Köhler, Tiago Granja, Julia Volz, Michael Koeppen, Harald F. Langer, Georg Hansmann, Ekaterina Legchenko, Tobias Geisler, Tamam Bakchoul, Claudia Eggstein, Helene A. Häberle, Bernhard Nieswandt, Peter Rosenberger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/2aada106ea4f4ec3b1d24ebbcb4e19ee
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spelling oai:doaj.org-article:2aada106ea4f4ec3b1d24ebbcb4e19ee2021-12-02T16:50:04ZRed blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb10.1038/s41467-020-14958-x2041-1723https://doaj.org/article/2aada106ea4f4ec3b1d24ebbcb4e19ee2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14958-xhttps://doaj.org/toc/2041-1723Reperfusion injury following myocardial ischemia is aggravated by inflammation and platelet–neutrophil complex formation. Here the authors show that semaphorin 7A binds to platelet GPIb, enhancing platelet–neutrophil interaction and increasing post-ischemic myocardial tissue injury, and that blockage of semaphorin 7A is protective.David KöhlerTiago GranjaJulia VolzMichael KoeppenHarald F. LangerGeorg HansmannEkaterina LegchenkoTobias GeislerTamam BakchoulClaudia EggsteinHelene A. HäberleBernhard NieswandtPeter RosenbergerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
David Köhler
Tiago Granja
Julia Volz
Michael Koeppen
Harald F. Langer
Georg Hansmann
Ekaterina Legchenko
Tobias Geisler
Tamam Bakchoul
Claudia Eggstein
Helene A. Häberle
Bernhard Nieswandt
Peter Rosenberger
Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb
description Reperfusion injury following myocardial ischemia is aggravated by inflammation and platelet–neutrophil complex formation. Here the authors show that semaphorin 7A binds to platelet GPIb, enhancing platelet–neutrophil interaction and increasing post-ischemic myocardial tissue injury, and that blockage of semaphorin 7A is protective.
format article
author David Köhler
Tiago Granja
Julia Volz
Michael Koeppen
Harald F. Langer
Georg Hansmann
Ekaterina Legchenko
Tobias Geisler
Tamam Bakchoul
Claudia Eggstein
Helene A. Häberle
Bernhard Nieswandt
Peter Rosenberger
author_facet David Köhler
Tiago Granja
Julia Volz
Michael Koeppen
Harald F. Langer
Georg Hansmann
Ekaterina Legchenko
Tobias Geisler
Tamam Bakchoul
Claudia Eggstein
Helene A. Häberle
Bernhard Nieswandt
Peter Rosenberger
author_sort David Köhler
title Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb
title_short Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb
title_full Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb
title_fullStr Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb
title_full_unstemmed Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb
title_sort red blood cell-derived semaphorin 7a promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet gpib
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/2aada106ea4f4ec3b1d24ebbcb4e19ee
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