CircRNA circVEGFC is Highly Expressed in Gestational Diabetes Mellitus (GDM) and It is Correlated with Multiple Adverse Events

Wenjing She, Tao Li, Yan Liu, Xinru Liu West China Second Hospital of Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu City, 610041, People’s Republic of ChinaCorrespondence: Xinru LiuWest China Second...

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Autores principales:	She W, Li T, Liu Y, Liu X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	circvegfc gestational diabetes mellitus adverse events Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/2aaef02ff64d48619f26fdd7b2d70468
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spelling	oai:doaj.org-article:2aaef02ff64d48619f26fdd7b2d704682021-12-02T19:31:58ZCircRNA circVEGFC is Highly Expressed in Gestational Diabetes Mellitus (GDM) and It is Correlated with Multiple Adverse Events1178-7007https://doaj.org/article/2aaef02ff64d48619f26fdd7b2d704682021-11-01T00:00:00Zhttps://www.dovepress.com/circrna-circvegfc-is-highly-expressed-in-gestational-diabetes-mellitus-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Wenjing She, Tao Li, Yan Liu, Xinru Liu West China Second Hospital of Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu City, 610041, People’s Republic of ChinaCorrespondence: Xinru LiuWest China Second Hospital of Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, No. 20, Section, 3, Renmin South Road, Wuhou District, Chengdu City, 610041, People’s Republic of ChinaTel +86-028-85503067Email xinruliudisease@163.comBackground: Circular RNA vascular endothelial growth factor C (circVEGFC) is a novel regulator of glucose metabolism, while its role in gestational diabetes mellitus (GDM) is unclear. This study aimed to detect the expression of circVEGFC in GDM and explore its clinical values.Methods: This study enrolled 220 pregnant women (gestational age less than 5 weeks) with normal blood glucose level on the day of admission. The expression of circVEGFC in plasma samples of these participants was determined by RT-qPCR. The participants were divided into high and low circVEGFC level groups with the median expression level of plasma circVEGFC as the cutoff value. The development of GDM was monitored until delivery. Adverse events were also monitored.Results: Compared to low circVEGFC level group, GDM-free curve analysis revealed significantly higher incidence of GDM in high circVEGFC level group. In addition, plasma expression levels of circVEGFC were also higher in GDM patients than that in non-GDM patients on the day of admission and at 1 month before and after delivery. ROC curve analysis revealed that high expression levels of circVEGFC on the day of admission showed higher sensitivity and specificity in the early diagnosis of GDM. Moreover, high circVEGFC level group showed higher incidence rates of fetal malformation and hypertension.Conclusion: Therefore, circVEGFC is highly expressed in GDM, and it is correlated with multiple adverse events.Keywords: circVEGFC, gestational diabetes mellitus, adverse eventsShe WLi TLiu YLiu XDove Medical Pressarticlecircvegfcgestational diabetes mellitusadverse eventsSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 4409-4414 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circvegfc gestational diabetes mellitus adverse events Specialties of internal medicine RC581-951
spellingShingle	circvegfc gestational diabetes mellitus adverse events Specialties of internal medicine RC581-951 She W Li T Liu Y Liu X CircRNA circVEGFC is Highly Expressed in Gestational Diabetes Mellitus (GDM) and It is Correlated with Multiple Adverse Events
description	Wenjing She, Tao Li, Yan Liu, Xinru Liu West China Second Hospital of Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu City, 610041, People’s Republic of ChinaCorrespondence: Xinru LiuWest China Second Hospital of Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, No. 20, Section, 3, Renmin South Road, Wuhou District, Chengdu City, 610041, People’s Republic of ChinaTel +86-028-85503067Email xinruliudisease@163.comBackground: Circular RNA vascular endothelial growth factor C (circVEGFC) is a novel regulator of glucose metabolism, while its role in gestational diabetes mellitus (GDM) is unclear. This study aimed to detect the expression of circVEGFC in GDM and explore its clinical values.Methods: This study enrolled 220 pregnant women (gestational age less than 5 weeks) with normal blood glucose level on the day of admission. The expression of circVEGFC in plasma samples of these participants was determined by RT-qPCR. The participants were divided into high and low circVEGFC level groups with the median expression level of plasma circVEGFC as the cutoff value. The development of GDM was monitored until delivery. Adverse events were also monitored.Results: Compared to low circVEGFC level group, GDM-free curve analysis revealed significantly higher incidence of GDM in high circVEGFC level group. In addition, plasma expression levels of circVEGFC were also higher in GDM patients than that in non-GDM patients on the day of admission and at 1 month before and after delivery. ROC curve analysis revealed that high expression levels of circVEGFC on the day of admission showed higher sensitivity and specificity in the early diagnosis of GDM. Moreover, high circVEGFC level group showed higher incidence rates of fetal malformation and hypertension.Conclusion: Therefore, circVEGFC is highly expressed in GDM, and it is correlated with multiple adverse events.Keywords: circVEGFC, gestational diabetes mellitus, adverse events
format	article
author	She W Li T Liu Y Liu X
author_facet	She W Li T Liu Y Liu X
author_sort	She W
title	CircRNA circVEGFC is Highly Expressed in Gestational Diabetes Mellitus (GDM) and It is Correlated with Multiple Adverse Events
title_short	CircRNA circVEGFC is Highly Expressed in Gestational Diabetes Mellitus (GDM) and It is Correlated with Multiple Adverse Events
title_full	CircRNA circVEGFC is Highly Expressed in Gestational Diabetes Mellitus (GDM) and It is Correlated with Multiple Adverse Events
title_fullStr	CircRNA circVEGFC is Highly Expressed in Gestational Diabetes Mellitus (GDM) and It is Correlated with Multiple Adverse Events
title_full_unstemmed	CircRNA circVEGFC is Highly Expressed in Gestational Diabetes Mellitus (GDM) and It is Correlated with Multiple Adverse Events
title_sort	circrna circvegfc is highly expressed in gestational diabetes mellitus (gdm) and it is correlated with multiple adverse events
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/2aaef02ff64d48619f26fdd7b2d70468
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CircRNA circVEGFC is Highly Expressed in Gestational Diabetes Mellitus (GDM) and It is Correlated with Multiple Adverse Events

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