Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function

ApoE4 is a risk factor for small vessel disease, which can lead to cognitive impairment. Here the authors assess the microvasculature of the corpus callosum using 3-photon microscopy and find that mice expressing the ApoE4 allele are more susceptible than wild-type to white matter injury and cogniti...

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Autores principales:	Kenzo Koizumi, Yorito Hattori, Sung Ji Ahn, Izaskun Buendia, Antonio Ciacciarelli, Ken Uekawa, Gang Wang, Abigail Hiller, Lingzhi Zhao, Henning U. Voss, Steven M. Paul, Chris Schaffer, Laibaik Park, Costantino Iadecola
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2ab1466f234d4ba0b18f5463e1f09a16
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spelling	oai:doaj.org-article:2ab1466f234d4ba0b18f5463e1f09a162021-12-02T15:34:41ZApoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function10.1038/s41467-018-06301-22041-1723https://doaj.org/article/2ab1466f234d4ba0b18f5463e1f09a162018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06301-2https://doaj.org/toc/2041-1723ApoE4 is a risk factor for small vessel disease, which can lead to cognitive impairment. Here the authors assess the microvasculature of the corpus callosum using 3-photon microscopy and find that mice expressing the ApoE4 allele are more susceptible than wild-type to white matter injury and cognitive impairment in a model of hypoperfusion-induced hypoxia.Kenzo KoizumiYorito HattoriSung Ji AhnIzaskun BuendiaAntonio CiacciarelliKen UekawaGang WangAbigail HillerLingzhi ZhaoHenning U. VossSteven M. PaulChris SchafferLaibaik ParkCostantino IadecolaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kenzo Koizumi Yorito Hattori Sung Ji Ahn Izaskun Buendia Antonio Ciacciarelli Ken Uekawa Gang Wang Abigail Hiller Lingzhi Zhao Henning U. Voss Steven M. Paul Chris Schaffer Laibaik Park Costantino Iadecola Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function
description	ApoE4 is a risk factor for small vessel disease, which can lead to cognitive impairment. Here the authors assess the microvasculature of the corpus callosum using 3-photon microscopy and find that mice expressing the ApoE4 allele are more susceptible than wild-type to white matter injury and cognitive impairment in a model of hypoperfusion-induced hypoxia.
format	article
author	Kenzo Koizumi Yorito Hattori Sung Ji Ahn Izaskun Buendia Antonio Ciacciarelli Ken Uekawa Gang Wang Abigail Hiller Lingzhi Zhao Henning U. Voss Steven M. Paul Chris Schaffer Laibaik Park Costantino Iadecola
author_facet	Kenzo Koizumi Yorito Hattori Sung Ji Ahn Izaskun Buendia Antonio Ciacciarelli Ken Uekawa Gang Wang Abigail Hiller Lingzhi Zhao Henning U. Voss Steven M. Paul Chris Schaffer Laibaik Park Costantino Iadecola
author_sort	Kenzo Koizumi
title	Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function
title_short	Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function
title_full	Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function
title_fullStr	Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function
title_full_unstemmed	Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function
title_sort	apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2ab1466f234d4ba0b18f5463e1f09a16
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Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function

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