Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

Caspase-1, activated by stress in immune cells and in CNS human neurons, may contribute to neuronal degeneration. Here, the authors investigate the therapeutic potential of a Caspase-1 inhibitor in a mouse model of Alzheimer’s disease.

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Autores principales:	Joseph Flores, Anastasia Noël, Bénédicte Foveau, Jeffrey Lynham, Clotilde Lecrux, Andréa C. LeBlanc
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2ab3ce42e3eb4a95a13cf8e46e06bf48
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spelling	oai:doaj.org-article:2ab3ce42e3eb4a95a13cf8e46e06bf482021-12-02T17:31:29ZCaspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model10.1038/s41467-018-06449-x2041-1723https://doaj.org/article/2ab3ce42e3eb4a95a13cf8e46e06bf482018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06449-xhttps://doaj.org/toc/2041-1723Caspase-1, activated by stress in immune cells and in CNS human neurons, may contribute to neuronal degeneration. Here, the authors investigate the therapeutic potential of a Caspase-1 inhibitor in a mouse model of Alzheimer’s disease.Joseph FloresAnastasia NoëlBénédicte FoveauJeffrey LynhamClotilde LecruxAndréa C. LeBlancNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joseph Flores Anastasia Noël Bénédicte Foveau Jeffrey Lynham Clotilde Lecrux Andréa C. LeBlanc Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model
description	Caspase-1, activated by stress in immune cells and in CNS human neurons, may contribute to neuronal degeneration. Here, the authors investigate the therapeutic potential of a Caspase-1 inhibitor in a mouse model of Alzheimer’s disease.
format	article
author	Joseph Flores Anastasia Noël Bénédicte Foveau Jeffrey Lynham Clotilde Lecrux Andréa C. LeBlanc
author_facet	Joseph Flores Anastasia Noël Bénédicte Foveau Jeffrey Lynham Clotilde Lecrux Andréa C. LeBlanc
author_sort	Joseph Flores
title	Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model
title_short	Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model
title_full	Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model
title_fullStr	Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model
title_full_unstemmed	Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model
title_sort	caspase-1 inhibition alleviates cognitive impairment and neuropathology in an alzheimer’s disease mouse model
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2ab3ce42e3eb4a95a13cf8e46e06bf48
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Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

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