Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA
Elderly males are often affected by benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS), but their link to prostate cancer risk is not well defined. Here, a genome-wide association study of BPH/LUTS patients from Iceland and the UK found 23 significant variants at 14...
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Nature Portfolio
2018
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oai:doaj.org-article:2ab3f1af06ec4c619f53cc3075130ef02021-12-02T14:39:45ZGenome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA10.1038/s41467-018-06920-92041-1723https://doaj.org/article/2ab3f1af06ec4c619f53cc3075130ef02018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06920-9https://doaj.org/toc/2041-1723Elderly males are often affected by benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS), but their link to prostate cancer risk is not well defined. Here, a genome-wide association study of BPH/LUTS patients from Iceland and the UK found 23 significant variants at 14 loci, and 15 of these variants associate with prostate specific antigen, which is linked to prostate cancer risk.Julius GudmundssonJon K. SigurdssonLilja StefansdottirBjarni A. AgnarssonHelgi J. IsakssonOlafur A. StefanssonSigurjon A. GudjonssonDaniel F. GudbjartssonGisli MassonMichael L. FriggeSimon N. StaceyPatrick SulemGisli H. HalldorssonVinicius TraganteHilma HolmGudmundur I. EyjolfssonOlof SigurdardottirIsleifur OlafssonThorvaldur JonssonEirikur JonssonRosa B. BarkardottirRafn HilmarssonFolkert W. AsselbergsGudmundur GeirssonUnnur ThorsteinsdottirThorunn RafnarGudmar ThorleifssonKari StefanssonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Julius Gudmundsson Jon K. Sigurdsson Lilja Stefansdottir Bjarni A. Agnarsson Helgi J. Isaksson Olafur A. Stefansson Sigurjon A. Gudjonsson Daniel F. Gudbjartsson Gisli Masson Michael L. Frigge Simon N. Stacey Patrick Sulem Gisli H. Halldorsson Vinicius Tragante Hilma Holm Gudmundur I. Eyjolfsson Olof Sigurdardottir Isleifur Olafsson Thorvaldur Jonsson Eirikur Jonsson Rosa B. Barkardottir Rafn Hilmarsson Folkert W. Asselbergs Gudmundur Geirsson Unnur Thorsteinsdottir Thorunn Rafnar Gudmar Thorleifsson Kari Stefansson Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA |
| description |
Elderly males are often affected by benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS), but their link to prostate cancer risk is not well defined. Here, a genome-wide association study of BPH/LUTS patients from Iceland and the UK found 23 significant variants at 14 loci, and 15 of these variants associate with prostate specific antigen, which is linked to prostate cancer risk. |
| format |
article |
| author |
Julius Gudmundsson Jon K. Sigurdsson Lilja Stefansdottir Bjarni A. Agnarsson Helgi J. Isaksson Olafur A. Stefansson Sigurjon A. Gudjonsson Daniel F. Gudbjartsson Gisli Masson Michael L. Frigge Simon N. Stacey Patrick Sulem Gisli H. Halldorsson Vinicius Tragante Hilma Holm Gudmundur I. Eyjolfsson Olof Sigurdardottir Isleifur Olafsson Thorvaldur Jonsson Eirikur Jonsson Rosa B. Barkardottir Rafn Hilmarsson Folkert W. Asselbergs Gudmundur Geirsson Unnur Thorsteinsdottir Thorunn Rafnar Gudmar Thorleifsson Kari Stefansson |
| author_facet |
Julius Gudmundsson Jon K. Sigurdsson Lilja Stefansdottir Bjarni A. Agnarsson Helgi J. Isaksson Olafur A. Stefansson Sigurjon A. Gudjonsson Daniel F. Gudbjartsson Gisli Masson Michael L. Frigge Simon N. Stacey Patrick Sulem Gisli H. Halldorsson Vinicius Tragante Hilma Holm Gudmundur I. Eyjolfsson Olof Sigurdardottir Isleifur Olafsson Thorvaldur Jonsson Eirikur Jonsson Rosa B. Barkardottir Rafn Hilmarsson Folkert W. Asselbergs Gudmundur Geirsson Unnur Thorsteinsdottir Thorunn Rafnar Gudmar Thorleifsson Kari Stefansson |
| author_sort |
Julius Gudmundsson |
| title |
Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA |
| title_short |
Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA |
| title_full |
Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA |
| title_fullStr |
Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA |
| title_full_unstemmed |
Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA |
| title_sort |
genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of psa |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/2ab3f1af06ec4c619f53cc3075130ef0 |
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