AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis

In diffuse large B-cell lymphoma (DLBCL) increased epigenetic heterogeneity in the form of cytosine methylation is known to link to a poor clinical outcome. Here, the authors show that AICDA, an enzyme required for DLBCL pathogenesis, increases cytosine methylation heterogeneity.

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Autores principales:	Matt Teater, Pilar M. Dominguez, David Redmond, Zhengming Chen, Daisuke Ennishi, David W. Scott, Luisa Cimmino, Paola Ghione, Jayanta Chaudhuri, Randy D. Gascoyne, Iannis Aifantis, Giorgio Inghirami, Olivier Elemento, Ari Melnick, Rita Shaknovich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2ab5189f12dc4d89ac687ffb7d5bf306
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spelling	oai:doaj.org-article:2ab5189f12dc4d89ac687ffb7d5bf3062021-12-02T14:39:08ZAICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis10.1038/s41467-017-02595-w2041-1723https://doaj.org/article/2ab5189f12dc4d89ac687ffb7d5bf3062018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02595-whttps://doaj.org/toc/2041-1723In diffuse large B-cell lymphoma (DLBCL) increased epigenetic heterogeneity in the form of cytosine methylation is known to link to a poor clinical outcome. Here, the authors show that AICDA, an enzyme required for DLBCL pathogenesis, increases cytosine methylation heterogeneity.Matt TeaterPilar M. DominguezDavid RedmondZhengming ChenDaisuke EnnishiDavid W. ScottLuisa CimminoPaola GhioneJayanta ChaudhuriRandy D. GascoyneIannis AifantisGiorgio InghiramiOlivier ElementoAri MelnickRita ShaknovichNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matt Teater Pilar M. Dominguez David Redmond Zhengming Chen Daisuke Ennishi David W. Scott Luisa Cimmino Paola Ghione Jayanta Chaudhuri Randy D. Gascoyne Iannis Aifantis Giorgio Inghirami Olivier Elemento Ari Melnick Rita Shaknovich AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis
description	In diffuse large B-cell lymphoma (DLBCL) increased epigenetic heterogeneity in the form of cytosine methylation is known to link to a poor clinical outcome. Here, the authors show that AICDA, an enzyme required for DLBCL pathogenesis, increases cytosine methylation heterogeneity.
format	article
author	Matt Teater Pilar M. Dominguez David Redmond Zhengming Chen Daisuke Ennishi David W. Scott Luisa Cimmino Paola Ghione Jayanta Chaudhuri Randy D. Gascoyne Iannis Aifantis Giorgio Inghirami Olivier Elemento Ari Melnick Rita Shaknovich
author_facet	Matt Teater Pilar M. Dominguez David Redmond Zhengming Chen Daisuke Ennishi David W. Scott Luisa Cimmino Paola Ghione Jayanta Chaudhuri Randy D. Gascoyne Iannis Aifantis Giorgio Inghirami Olivier Elemento Ari Melnick Rita Shaknovich
author_sort	Matt Teater
title	AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis
title_short	AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis
title_full	AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis
title_fullStr	AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis
title_full_unstemmed	AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis
title_sort	aicda drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2ab5189f12dc4d89ac687ffb7d5bf306
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AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis

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