Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 Study.

Lower socioeconomic status (SES) is strongly associated with an increased risk of morbidity and premature mortality, but it is not known if the same is true for telomere length, a marker often used to assess biological ageing. The West of Scotland Twenty-07 Study was used to investigate this and con...

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Autores principales:	Tony Robertson, G David Batty, Geoff Der, Michael J Green, Liane M McGlynn, Alan McIntyre, Paul G Shiels, Michaela Benzeval
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2abb5a2c189949279851c74c5826cf24
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spelling	oai:doaj.org-article:2abb5a2c189949279851c74c5826cf242021-11-18T07:11:28ZIs telomere length socially patterned? Evidence from the West of Scotland Twenty-07 Study.1932-620310.1371/journal.pone.0041805https://doaj.org/article/2abb5a2c189949279851c74c5826cf242012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22844525/?tool=EBIhttps://doaj.org/toc/1932-6203Lower socioeconomic status (SES) is strongly associated with an increased risk of morbidity and premature mortality, but it is not known if the same is true for telomere length, a marker often used to assess biological ageing. The West of Scotland Twenty-07 Study was used to investigate this and consists of three cohorts aged approximately 35 (N = 775), 55 (N = 866) and 75 years (N = 544) at the time of telomere length measurement. Four sets of measurements of SES were investigated: those collected contemporaneously with telomere length assessment, educational markers, SES in childhood and SES over the preceding twenty years. We found mixed evidence for an association between SES and telomere length. In 35-year-olds, many of the education and childhood SES measures were associated with telomere length, i.e. those in poorer circumstances had shorter telomeres, as was intergenerational social mobility, but not accumulated disadvantage. A crude estimate showed that, at the same chronological age, social renters, for example, were nine years (biologically) older than home owners. No consistent associations were apparent in those aged 55 or 75. There is evidence of an association between SES and telomere length, but only in younger adults and most strongly using education and childhood SES measures. These results may reflect that childhood is a sensitive period for telomere attrition. The cohort differences are possibly the result of survival bias suppressing the SES-telomere association; cohort effects with regard different experiences of SES; or telomere possibly being a less effective marker of biological ageing at older ages.Tony RobertsonG David BattyGeoff DerMichael J GreenLiane M McGlynnAlan McIntyrePaul G ShielsMichaela BenzevalPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e41805 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tony Robertson G David Batty Geoff Der Michael J Green Liane M McGlynn Alan McIntyre Paul G Shiels Michaela Benzeval Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 Study.
description	Lower socioeconomic status (SES) is strongly associated with an increased risk of morbidity and premature mortality, but it is not known if the same is true for telomere length, a marker often used to assess biological ageing. The West of Scotland Twenty-07 Study was used to investigate this and consists of three cohorts aged approximately 35 (N = 775), 55 (N = 866) and 75 years (N = 544) at the time of telomere length measurement. Four sets of measurements of SES were investigated: those collected contemporaneously with telomere length assessment, educational markers, SES in childhood and SES over the preceding twenty years. We found mixed evidence for an association between SES and telomere length. In 35-year-olds, many of the education and childhood SES measures were associated with telomere length, i.e. those in poorer circumstances had shorter telomeres, as was intergenerational social mobility, but not accumulated disadvantage. A crude estimate showed that, at the same chronological age, social renters, for example, were nine years (biologically) older than home owners. No consistent associations were apparent in those aged 55 or 75. There is evidence of an association between SES and telomere length, but only in younger adults and most strongly using education and childhood SES measures. These results may reflect that childhood is a sensitive period for telomere attrition. The cohort differences are possibly the result of survival bias suppressing the SES-telomere association; cohort effects with regard different experiences of SES; or telomere possibly being a less effective marker of biological ageing at older ages.
format	article
author	Tony Robertson G David Batty Geoff Der Michael J Green Liane M McGlynn Alan McIntyre Paul G Shiels Michaela Benzeval
author_facet	Tony Robertson G David Batty Geoff Der Michael J Green Liane M McGlynn Alan McIntyre Paul G Shiels Michaela Benzeval
author_sort	Tony Robertson
title	Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 Study.
title_short	Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 Study.
title_full	Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 Study.
title_fullStr	Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 Study.
title_full_unstemmed	Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 Study.
title_sort	is telomere length socially patterned? evidence from the west of scotland twenty-07 study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/2abb5a2c189949279851c74c5826cf24
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Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 Study.

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