BMI1 enables interspecies chimerism with human pluripotent stem cells

Conventional human pluripotent stem cells (hPSCs) fail to contribute to interspecies chimaeras when injected into mouse blastocysts. Here the authors show that forced expression of BMI1 overcomes apoptosis of hPSCs in blastocysts of mouse, rabbit and pig allowing them to contribute to chimaeras.

Guardado en:

Detalles Bibliográficos
Autores principales:	Ke Huang, Yanling Zhu, Yanlin Ma, Bentian Zhao, Nana Fan, Yuhang Li, Hong Song, Shilong Chu, Zhen Ouyang, Quanjun Zhang, Qi Xing, Chengdan Lai, Nan Li, Tian Zhang, Jiaming Gu, Baoqiang Kang, Yongli Shan, Keyu Lai, Wenhao Huang, Yuchan Mai, Qing Wang, Jinbing Li, Aiping Lin, Yanqi Zhang, Xiaofen Zhong, Baojian Liao, Liangxue Lai, Jiekai Chen, Duanqing Pei, Guangjin Pan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2abbe79b23a8490c97938adbb303433b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2abbe79b23a8490c97938adbb303433b
record_format	dspace
spelling	oai:doaj.org-article:2abbe79b23a8490c97938adbb303433b2021-12-02T16:49:49ZBMI1 enables interspecies chimerism with human pluripotent stem cells10.1038/s41467-018-07098-w2041-1723https://doaj.org/article/2abbe79b23a8490c97938adbb303433b2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07098-whttps://doaj.org/toc/2041-1723Conventional human pluripotent stem cells (hPSCs) fail to contribute to interspecies chimaeras when injected into mouse blastocysts. Here the authors show that forced expression of BMI1 overcomes apoptosis of hPSCs in blastocysts of mouse, rabbit and pig allowing them to contribute to chimaeras.Ke HuangYanling ZhuYanlin MaBentian ZhaoNana FanYuhang LiHong SongShilong ChuZhen OuyangQuanjun ZhangQi XingChengdan LaiNan LiTian ZhangJiaming GuBaoqiang KangYongli ShanKeyu LaiWenhao HuangYuchan MaiQing WangJinbing LiAiping LinYanqi ZhangXiaofen ZhongBaojian LiaoLiangxue LaiJiekai ChenDuanqing PeiGuangjin PanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ke Huang Yanling Zhu Yanlin Ma Bentian Zhao Nana Fan Yuhang Li Hong Song Shilong Chu Zhen Ouyang Quanjun Zhang Qi Xing Chengdan Lai Nan Li Tian Zhang Jiaming Gu Baoqiang Kang Yongli Shan Keyu Lai Wenhao Huang Yuchan Mai Qing Wang Jinbing Li Aiping Lin Yanqi Zhang Xiaofen Zhong Baojian Liao Liangxue Lai Jiekai Chen Duanqing Pei Guangjin Pan BMI1 enables interspecies chimerism with human pluripotent stem cells
description	Conventional human pluripotent stem cells (hPSCs) fail to contribute to interspecies chimaeras when injected into mouse blastocysts. Here the authors show that forced expression of BMI1 overcomes apoptosis of hPSCs in blastocysts of mouse, rabbit and pig allowing them to contribute to chimaeras.
format	article
author	Ke Huang Yanling Zhu Yanlin Ma Bentian Zhao Nana Fan Yuhang Li Hong Song Shilong Chu Zhen Ouyang Quanjun Zhang Qi Xing Chengdan Lai Nan Li Tian Zhang Jiaming Gu Baoqiang Kang Yongli Shan Keyu Lai Wenhao Huang Yuchan Mai Qing Wang Jinbing Li Aiping Lin Yanqi Zhang Xiaofen Zhong Baojian Liao Liangxue Lai Jiekai Chen Duanqing Pei Guangjin Pan
author_facet	Ke Huang Yanling Zhu Yanlin Ma Bentian Zhao Nana Fan Yuhang Li Hong Song Shilong Chu Zhen Ouyang Quanjun Zhang Qi Xing Chengdan Lai Nan Li Tian Zhang Jiaming Gu Baoqiang Kang Yongli Shan Keyu Lai Wenhao Huang Yuchan Mai Qing Wang Jinbing Li Aiping Lin Yanqi Zhang Xiaofen Zhong Baojian Liao Liangxue Lai Jiekai Chen Duanqing Pei Guangjin Pan
author_sort	Ke Huang
title	BMI1 enables interspecies chimerism with human pluripotent stem cells
title_short	BMI1 enables interspecies chimerism with human pluripotent stem cells
title_full	BMI1 enables interspecies chimerism with human pluripotent stem cells
title_fullStr	BMI1 enables interspecies chimerism with human pluripotent stem cells
title_full_unstemmed	BMI1 enables interspecies chimerism with human pluripotent stem cells
title_sort	bmi1 enables interspecies chimerism with human pluripotent stem cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2abbe79b23a8490c97938adbb303433b
work_keys_str_mv	AT kehuang bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT yanlingzhu bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT yanlinma bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT bentianzhao bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT nanafan bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT yuhangli bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT hongsong bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT shilongchu bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT zhenouyang bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT quanjunzhang bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT qixing bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT chengdanlai bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT nanli bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT tianzhang bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT jiaminggu bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT baoqiangkang bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT yonglishan bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT keyulai bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT wenhaohuang bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT yuchanmai bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT qingwang bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT jinbingli bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT aipinglin bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT yanqizhang bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT xiaofenzhong bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT baojianliao bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT liangxuelai bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT jiekaichen bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT duanqingpei bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells AT guangjinpan bmi1enablesinterspecieschimerismwithhumanpluripotentstemcells
_version_	1718383204915740672

BMI1 enables interspecies chimerism with human pluripotent stem cells

Ejemplares similares