Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles

The stromal cells and extracellular matrix hamper nanoparticle access to cancer cells and their anti-cancer efficacy. Here, the authors report a bioinspired lipoprotein (bLP) for photothermal remodelling of tumour stroma and show this to improve subsequent bLP accessibility to cancer cells.

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Autores principales: Tao Tan, Haiyan Hu, Hong Wang, Jie Li, Zhiwan Wang, Jing Wang, Siling Wang, Zhiwen Zhang, Yaping Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/2abc957b2cc24032921ee8d5cf470610
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spelling oai:doaj.org-article:2abc957b2cc24032921ee8d5cf4706102021-12-02T17:01:27ZBioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles10.1038/s41467-019-11235-42041-1723https://doaj.org/article/2abc957b2cc24032921ee8d5cf4706102019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11235-4https://doaj.org/toc/2041-1723The stromal cells and extracellular matrix hamper nanoparticle access to cancer cells and their anti-cancer efficacy. Here, the authors report a bioinspired lipoprotein (bLP) for photothermal remodelling of tumour stroma and show this to improve subsequent bLP accessibility to cancer cells.Tao TanHaiyan HuHong WangJie LiZhiwan WangJing WangSiling WangZhiwen ZhangYaping LiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tao Tan
Haiyan Hu
Hong Wang
Jie Li
Zhiwan Wang
Jing Wang
Siling Wang
Zhiwen Zhang
Yaping Li
Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles
description The stromal cells and extracellular matrix hamper nanoparticle access to cancer cells and their anti-cancer efficacy. Here, the authors report a bioinspired lipoprotein (bLP) for photothermal remodelling of tumour stroma and show this to improve subsequent bLP accessibility to cancer cells.
format article
author Tao Tan
Haiyan Hu
Hong Wang
Jie Li
Zhiwan Wang
Jing Wang
Siling Wang
Zhiwen Zhang
Yaping Li
author_facet Tao Tan
Haiyan Hu
Hong Wang
Jie Li
Zhiwan Wang
Jing Wang
Siling Wang
Zhiwen Zhang
Yaping Li
author_sort Tao Tan
title Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles
title_short Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles
title_full Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles
title_fullStr Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles
title_full_unstemmed Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles
title_sort bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/2abc957b2cc24032921ee8d5cf470610
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AT haiyanhu bioinspiredlipoproteinsmediatedphotothermiaremodelstumorstromatoimprovecancercellaccessibilityofsecondnanoparticles
AT hongwang bioinspiredlipoproteinsmediatedphotothermiaremodelstumorstromatoimprovecancercellaccessibilityofsecondnanoparticles
AT jieli bioinspiredlipoproteinsmediatedphotothermiaremodelstumorstromatoimprovecancercellaccessibilityofsecondnanoparticles
AT zhiwanwang bioinspiredlipoproteinsmediatedphotothermiaremodelstumorstromatoimprovecancercellaccessibilityofsecondnanoparticles
AT jingwang bioinspiredlipoproteinsmediatedphotothermiaremodelstumorstromatoimprovecancercellaccessibilityofsecondnanoparticles
AT silingwang bioinspiredlipoproteinsmediatedphotothermiaremodelstumorstromatoimprovecancercellaccessibilityofsecondnanoparticles
AT zhiwenzhang bioinspiredlipoproteinsmediatedphotothermiaremodelstumorstromatoimprovecancercellaccessibilityofsecondnanoparticles
AT yapingli bioinspiredlipoproteinsmediatedphotothermiaremodelstumorstromatoimprovecancercellaccessibilityofsecondnanoparticles
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