Study of the Anticonvulsant Effects of Methanolic Extract of Tilia Plathyphyllos Scop. in Mice

BACKGROUND AND OBJECTIVE: There are some reports indicating the effects of Tilia plathyphyllos Scop. in nervous disorders including seizure in traditional literatures. Since classical study is not available, in the present investigation, the effects of methanolic extract of Tilia plathyphyllos Scop...

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Autores principales:	MR Heidari, M . Mehrabani, A Assadipour, H Moghadammanesh, MJ Heidari, J Vafazadeh
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2010
Materias:	tilia plathyphyllos seizure picrotoxin pentylentetrazole mice Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2abf6b177941423f80100566e1a79922
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spelling	oai:doaj.org-article:2abf6b177941423f80100566e1a799222021-11-10T09:00:07ZStudy of the Anticonvulsant Effects of Methanolic Extract of Tilia Plathyphyllos Scop. in Mice1561-41072251-7170https://doaj.org/article/2abf6b177941423f80100566e1a799222010-01-01T00:00:00Zhttp://jbums.org/article-1-3367-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: There are some reports indicating the effects of Tilia plathyphyllos Scop. in nervous disorders including seizure in traditional literatures. Since classical study is not available, in the present investigation, the effects of methanolic extract of Tilia plathyphyllos Scop on seizure induced by picrotoxin and pentylentetrazole were studied in mice. METHODS: In this experimental study, groups of 5 animals pretreated with doses of 100, 200 and 300 mg/kg of methanolic extract of flowered branches of Tilia plathyphyllos, via intraperitoneal injection. After 20 minutes each animal received picrotoxin 10 mg/kg or pentylentetrazole 80 mg/kg intraperitoneally, for induction of seizure. Latency of seizure, death time and percent of death were determined in treated and control groups.FINDINGS: The latency of seizure induce by picrotoxin were increased in groups that pretreated with doses of 100 and 200 mg/kg of Tilia plathyphyllos extract, from 208 Sec to 298 (p<0.05) and 570 Sec (p<0.01) respectively. The latency of seizure induced by pentylentetrazole were increased with dose of 200 mg/kg, from 233 Sec to 351 Sec (p<0.01). In addition the dose of 200 mg/kg of extract delayed the death time induced by picrotoxin from 1237 to 1498 Sec (p<0.05) and pentylentetrazole from 1973 to 2508 Sec (p<0.01). The percentage of mortality from seizure induced by picrotoxin and pentylentetrazole from 100% were decreased to 80% (p<0.05) and 40% (p<0.01) respectively.CONCLUSION: Methanolic extract of flowered branches of Tilia plathyphyllos delayed the onset of seizure, death time and decreased the percentage of mortality from picrotoxin and pentylentetrazole. Further studies are needed for use of this, as antiseizure.MR Heidari,M . MehrabaniA AssadipourH MoghadammaneshMJ Heidari,J VafazadehBabol University of Medical Sciencesarticletilia plathyphyllosseizurepicrotoxinpentylentetrazolemiceMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 11, Iss 6, Pp 7-15 (2010)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	tilia plathyphyllos seizure picrotoxin pentylentetrazole mice Medicine R Medicine (General) R5-920
spellingShingle	tilia plathyphyllos seizure picrotoxin pentylentetrazole mice Medicine R Medicine (General) R5-920 MR Heidari, M . Mehrabani A Assadipour H Moghadammanesh MJ Heidari, J Vafazadeh Study of the Anticonvulsant Effects of Methanolic Extract of Tilia Plathyphyllos Scop. in Mice
description	BACKGROUND AND OBJECTIVE: There are some reports indicating the effects of Tilia plathyphyllos Scop. in nervous disorders including seizure in traditional literatures. Since classical study is not available, in the present investigation, the effects of methanolic extract of Tilia plathyphyllos Scop on seizure induced by picrotoxin and pentylentetrazole were studied in mice. METHODS: In this experimental study, groups of 5 animals pretreated with doses of 100, 200 and 300 mg/kg of methanolic extract of flowered branches of Tilia plathyphyllos, via intraperitoneal injection. After 20 minutes each animal received picrotoxin 10 mg/kg or pentylentetrazole 80 mg/kg intraperitoneally, for induction of seizure. Latency of seizure, death time and percent of death were determined in treated and control groups.FINDINGS: The latency of seizure induce by picrotoxin were increased in groups that pretreated with doses of 100 and 200 mg/kg of Tilia plathyphyllos extract, from 208 Sec to 298 (p<0.05) and 570 Sec (p<0.01) respectively. The latency of seizure induced by pentylentetrazole were increased with dose of 200 mg/kg, from 233 Sec to 351 Sec (p<0.01). In addition the dose of 200 mg/kg of extract delayed the death time induced by picrotoxin from 1237 to 1498 Sec (p<0.05) and pentylentetrazole from 1973 to 2508 Sec (p<0.01). The percentage of mortality from seizure induced by picrotoxin and pentylentetrazole from 100% were decreased to 80% (p<0.05) and 40% (p<0.01) respectively.CONCLUSION: Methanolic extract of flowered branches of Tilia plathyphyllos delayed the onset of seizure, death time and decreased the percentage of mortality from picrotoxin and pentylentetrazole. Further studies are needed for use of this, as antiseizure.
format	article
author	MR Heidari, M . Mehrabani A Assadipour H Moghadammanesh MJ Heidari, J Vafazadeh
author_facet	MR Heidari, M . Mehrabani A Assadipour H Moghadammanesh MJ Heidari, J Vafazadeh
author_sort	MR Heidari,
title	Study of the Anticonvulsant Effects of Methanolic Extract of Tilia Plathyphyllos Scop. in Mice
title_short	Study of the Anticonvulsant Effects of Methanolic Extract of Tilia Plathyphyllos Scop. in Mice
title_full	Study of the Anticonvulsant Effects of Methanolic Extract of Tilia Plathyphyllos Scop. in Mice
title_fullStr	Study of the Anticonvulsant Effects of Methanolic Extract of Tilia Plathyphyllos Scop. in Mice
title_full_unstemmed	Study of the Anticonvulsant Effects of Methanolic Extract of Tilia Plathyphyllos Scop. in Mice
title_sort	study of the anticonvulsant effects of methanolic extract of tilia plathyphyllos scop. in mice
publisher	Babol University of Medical Sciences
publishDate	2010
url	https://doaj.org/article/2abf6b177941423f80100566e1a79922
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Study of the Anticonvulsant Effects of Methanolic Extract of Tilia Plathyphyllos Scop. in Mice

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