Association of leptin G2548A and leptin receptor Q223R polymorphisms and their serum levels with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome.

<h4>Background</h4>Adipokine leptin plays a crucial role in metabolic and reproductive functions. Leptin receptor has a soluble form that binds to leptin, thus modulating its level in the circulation. It has been indicated that the levels of leptin and leptin receptor and also LEP rs7799...

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Autores principales:	Fatemeh Bagheri Kargasheh, Soheila Ansaripour, Nasrin Borumandnia, Nariman Moradi, Zahra Zandieh, Monireh Maleki, Sara Mokhtar, Atousa Karimi, Farnaz Fatemi, Asma Kheirollahi, Akram Vatannejad
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2ac0605397324bf59b2e45ba4fbfefe0
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spelling	oai:doaj.org-article:2ac0605397324bf59b2e45ba4fbfefe02021-12-02T20:17:52ZAssociation of leptin G2548A and leptin receptor Q223R polymorphisms and their serum levels with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome.1932-620310.1371/journal.pone.0255920https://doaj.org/article/2ac0605397324bf59b2e45ba4fbfefe02021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255920https://doaj.org/toc/1932-6203<h4>Background</h4>Adipokine leptin plays a crucial role in metabolic and reproductive functions. Leptin receptor has a soluble form that binds to leptin, thus modulating its level in the circulation. It has been indicated that the levels of leptin and leptin receptor and also LEP rs7799039 and LEPR rs1137101 polymorphisms are associated with metabolic disorders. In the present study, we assessed the levels of leptin and soluble leptin receptor (sOB-R), and also the frequency of rs7799039 and rs1137101 polymorphisms in healthy fertile women and patients with polycystic ovary syndrome (PCOS), inclusive of PCOS-infertile and PCOS-recurrent pregnancy loss (RPL) subjects.<h4>Methods</h4>A total of 324 PCOS patients- including 199 infertile cases and 125 patients with a history of RPL- and 144 healthy controls were enrolled in this study. Biochemical parameters and plasma leptin and sOB-R levels were measured by ELISA and the genotypes of rs7799039 and rs1137101 polymorphisms were determined using PCR- RFLP.<h4>Results</h4>Plasma leptin and sOB-R levels were significantly higher and lower in PCOS, PCOS-infertile and PCOS RPL groups, respectively. The GG genotype frequencies of rs7799039 and rs1137101 polymorphisms were significantly different between PCOS-infertile women and non-PCOS subjects (P = 0.043, OR = 0.47, 95% CI = 0.22-0.97, and P = 0.01, OR = 0.31, 95% CI = 0.12-0.75, respectively). Increased LEP levels were associated with the risk of PCOS and RPL in women with PCOS (P = 0.039, OR = 1.203, 95%CI = [1.009-1.435] and P = 0.012, OR = 1.267, 95% CI = [1.054-1.522], respectively).<h4>Conclusion</h4>Polymorphisms rs7799039 and rs1137101 and circulating leptin and sOB-R levels were associated with infertility in Iranian women with PCOS. Further studies are needed to reveal the role of leptin in PCOS pathogenesis.Fatemeh Bagheri KargashehSoheila AnsaripourNasrin BorumandniaNariman MoradiZahra ZandiehMonireh MalekiSara MokhtarAtousa KarimiFarnaz FatemiAsma KheirollahiAkram VatannejadPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255920 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fatemeh Bagheri Kargasheh Soheila Ansaripour Nasrin Borumandnia Nariman Moradi Zahra Zandieh Monireh Maleki Sara Mokhtar Atousa Karimi Farnaz Fatemi Asma Kheirollahi Akram Vatannejad Association of leptin G2548A and leptin receptor Q223R polymorphisms and their serum levels with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome.
description	<h4>Background</h4>Adipokine leptin plays a crucial role in metabolic and reproductive functions. Leptin receptor has a soluble form that binds to leptin, thus modulating its level in the circulation. It has been indicated that the levels of leptin and leptin receptor and also LEP rs7799039 and LEPR rs1137101 polymorphisms are associated with metabolic disorders. In the present study, we assessed the levels of leptin and soluble leptin receptor (sOB-R), and also the frequency of rs7799039 and rs1137101 polymorphisms in healthy fertile women and patients with polycystic ovary syndrome (PCOS), inclusive of PCOS-infertile and PCOS-recurrent pregnancy loss (RPL) subjects.<h4>Methods</h4>A total of 324 PCOS patients- including 199 infertile cases and 125 patients with a history of RPL- and 144 healthy controls were enrolled in this study. Biochemical parameters and plasma leptin and sOB-R levels were measured by ELISA and the genotypes of rs7799039 and rs1137101 polymorphisms were determined using PCR- RFLP.<h4>Results</h4>Plasma leptin and sOB-R levels were significantly higher and lower in PCOS, PCOS-infertile and PCOS RPL groups, respectively. The GG genotype frequencies of rs7799039 and rs1137101 polymorphisms were significantly different between PCOS-infertile women and non-PCOS subjects (P = 0.043, OR = 0.47, 95% CI = 0.22-0.97, and P = 0.01, OR = 0.31, 95% CI = 0.12-0.75, respectively). Increased LEP levels were associated with the risk of PCOS and RPL in women with PCOS (P = 0.039, OR = 1.203, 95%CI = [1.009-1.435] and P = 0.012, OR = 1.267, 95% CI = [1.054-1.522], respectively).<h4>Conclusion</h4>Polymorphisms rs7799039 and rs1137101 and circulating leptin and sOB-R levels were associated with infertility in Iranian women with PCOS. Further studies are needed to reveal the role of leptin in PCOS pathogenesis.
format	article
author	Fatemeh Bagheri Kargasheh Soheila Ansaripour Nasrin Borumandnia Nariman Moradi Zahra Zandieh Monireh Maleki Sara Mokhtar Atousa Karimi Farnaz Fatemi Asma Kheirollahi Akram Vatannejad
author_facet	Fatemeh Bagheri Kargasheh Soheila Ansaripour Nasrin Borumandnia Nariman Moradi Zahra Zandieh Monireh Maleki Sara Mokhtar Atousa Karimi Farnaz Fatemi Asma Kheirollahi Akram Vatannejad
author_sort	Fatemeh Bagheri Kargasheh
title	Association of leptin G2548A and leptin receptor Q223R polymorphisms and their serum levels with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome.
title_short	Association of leptin G2548A and leptin receptor Q223R polymorphisms and their serum levels with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome.
title_full	Association of leptin G2548A and leptin receptor Q223R polymorphisms and their serum levels with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome.
title_fullStr	Association of leptin G2548A and leptin receptor Q223R polymorphisms and their serum levels with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome.
title_full_unstemmed	Association of leptin G2548A and leptin receptor Q223R polymorphisms and their serum levels with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome.
title_sort	association of leptin g2548a and leptin receptor q223r polymorphisms and their serum levels with infertility and recurrent pregnancy loss in iranian women with polycystic ovary syndrome.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/2ac0605397324bf59b2e45ba4fbfefe0
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Association of leptin G2548A and leptin receptor Q223R polymorphisms and their serum levels with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome.

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