Developmental chronodisruption alters placental signaling in mice.

Chronodisruption has been largely overlooked as a developmental exposure. The placenta, a conduit between the maternal and fetal environments, may relay circadian cues to the fetus. We have previously shown that developmental chronodisruption causes visual impairment and increased retinal microglial...

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Autores principales:	Danielle A Clarkson-Townsend, Katie L Bales, Karen E Hermetz, Amber A Burt, Machelle T Pardue, Carmen J Marsit
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2ac4e13894414ad18ba065c62b474fb7
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spelling	oai:doaj.org-article:2ac4e13894414ad18ba065c62b474fb72021-12-02T20:18:31ZDevelopmental chronodisruption alters placental signaling in mice.1932-620310.1371/journal.pone.0255296https://doaj.org/article/2ac4e13894414ad18ba065c62b474fb72021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255296https://doaj.org/toc/1932-6203Chronodisruption has been largely overlooked as a developmental exposure. The placenta, a conduit between the maternal and fetal environments, may relay circadian cues to the fetus. We have previously shown that developmental chronodisruption causes visual impairment and increased retinal microglial and macrophage marker expression. Here, we investigated the impacts of environmental chronodisruption on fetal and placental outcomes in a C57BL/6J mouse (Mus musculus) model. Developmental chronodisruption had no effect on embryo count, placental weight, or fetal sex ratio. When measured with RNAseq, mice exposed to developmental chronodisruption (CD) had differential placental expression of several transcripts including Serpinf1, which encodes pigment epithelium-derived factor (PEDF). Immunofluorescence of microglia/macrophage markers, Iba1 and CD11b, also revealed significant upregulation of immune cell markers in CD-exposed placenta. Our results suggest that in utero chronodisruption enhances placental immune cell expression, potentially programming a pro-inflammatory tissue environment.Danielle A Clarkson-TownsendKatie L BalesKaren E HermetzAmber A BurtMachelle T PardueCarmen J MarsitPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255296 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Danielle A Clarkson-Townsend Katie L Bales Karen E Hermetz Amber A Burt Machelle T Pardue Carmen J Marsit Developmental chronodisruption alters placental signaling in mice.
description	Chronodisruption has been largely overlooked as a developmental exposure. The placenta, a conduit between the maternal and fetal environments, may relay circadian cues to the fetus. We have previously shown that developmental chronodisruption causes visual impairment and increased retinal microglial and macrophage marker expression. Here, we investigated the impacts of environmental chronodisruption on fetal and placental outcomes in a C57BL/6J mouse (Mus musculus) model. Developmental chronodisruption had no effect on embryo count, placental weight, or fetal sex ratio. When measured with RNAseq, mice exposed to developmental chronodisruption (CD) had differential placental expression of several transcripts including Serpinf1, which encodes pigment epithelium-derived factor (PEDF). Immunofluorescence of microglia/macrophage markers, Iba1 and CD11b, also revealed significant upregulation of immune cell markers in CD-exposed placenta. Our results suggest that in utero chronodisruption enhances placental immune cell expression, potentially programming a pro-inflammatory tissue environment.
format	article
author	Danielle A Clarkson-Townsend Katie L Bales Karen E Hermetz Amber A Burt Machelle T Pardue Carmen J Marsit
author_facet	Danielle A Clarkson-Townsend Katie L Bales Karen E Hermetz Amber A Burt Machelle T Pardue Carmen J Marsit
author_sort	Danielle A Clarkson-Townsend
title	Developmental chronodisruption alters placental signaling in mice.
title_short	Developmental chronodisruption alters placental signaling in mice.
title_full	Developmental chronodisruption alters placental signaling in mice.
title_fullStr	Developmental chronodisruption alters placental signaling in mice.
title_full_unstemmed	Developmental chronodisruption alters placental signaling in mice.
title_sort	developmental chronodisruption alters placental signaling in mice.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/2ac4e13894414ad18ba065c62b474fb7
work_keys_str_mv	AT danielleaclarksontownsend developmentalchronodisruptionaltersplacentalsignalinginmice AT katielbales developmentalchronodisruptionaltersplacentalsignalinginmice AT karenehermetz developmentalchronodisruptionaltersplacentalsignalinginmice AT amberaburt developmentalchronodisruptionaltersplacentalsignalinginmice AT machelletpardue developmentalchronodisruptionaltersplacentalsignalinginmice AT carmenjmarsit developmentalchronodisruptionaltersplacentalsignalinginmice
_version_	1718374275526688768

Developmental chronodisruption alters placental signaling in mice.

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