Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite

Abstract Novel synthesized Chitosan–Copper oxide nanocomposite (Cs–CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method. The characterization of biogenic nanoparticl...

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Autores principales:	Somia B. Ahmed, Hadeer I. Mohamed, Abeer M. Al-Subaie, Ahoud I. Al-Ohali, Nesrine M. R. Mahmoud
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2ac58b060cf04240b1455829f9009213
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spelling	oai:doaj.org-article:2ac58b060cf04240b1455829f90092132021-12-02T15:38:23ZInvestigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite10.1038/s41598-021-88907-z2045-2322https://doaj.org/article/2ac58b060cf04240b1455829f90092132021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88907-zhttps://doaj.org/toc/2045-2322Abstract Novel synthesized Chitosan–Copper oxide nanocomposite (Cs–CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method. The characterization of biogenic nanoparticles Cs-NP's and Cs–CuO-NP's was investigated structurally, morphologically to determine all the significant characters of those nanoparticles. Antimicrobial activity was tested for both Cs-NP's and Cs–CuO-NP's via minimum inhibition concentration and zone analysis against fungus, gram-positive and gram-negative. The antimicrobial test results showed high sensitivity of Cs–CuO-NP's to all microorganisms tested in a concentration less than 20,000 mg/L, while the sensitivity of Cs-NP's against all microorganisms under the test started from a concentration of 20,000–40,000 mg/L except for the C. albicans species. The hematological activity was also tested via measuring the RBCs, platelet count, and clotting time against healthy, diabetic, and hypercholesteremia blood samples. The measurement showed a decrease in RBCs and platelet count by adding Cs-NP’s or Cs–CuO-NP's to the three blood samples. Cs-NP's success in decreasing the clotting time for healthy and diabetic blood acting as a procoagulant agent while adding biogenic CuO-NP’s to Cs-NP’s increased clotting time considering as an anti-coagulant agent for hypercholesteremia blood samples.Somia B. AhmedHadeer I. MohamedAbeer M. Al-SubaieAhoud I. Al-OhaliNesrine M. R. MahmoudNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Somia B. Ahmed Hadeer I. Mohamed Abeer M. Al-Subaie Ahoud I. Al-Ohali Nesrine M. R. Mahmoud Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite
description	Abstract Novel synthesized Chitosan–Copper oxide nanocomposite (Cs–CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method. The characterization of biogenic nanoparticles Cs-NP's and Cs–CuO-NP's was investigated structurally, morphologically to determine all the significant characters of those nanoparticles. Antimicrobial activity was tested for both Cs-NP's and Cs–CuO-NP's via minimum inhibition concentration and zone analysis against fungus, gram-positive and gram-negative. The antimicrobial test results showed high sensitivity of Cs–CuO-NP's to all microorganisms tested in a concentration less than 20,000 mg/L, while the sensitivity of Cs-NP's against all microorganisms under the test started from a concentration of 20,000–40,000 mg/L except for the C. albicans species. The hematological activity was also tested via measuring the RBCs, platelet count, and clotting time against healthy, diabetic, and hypercholesteremia blood samples. The measurement showed a decrease in RBCs and platelet count by adding Cs-NP’s or Cs–CuO-NP's to the three blood samples. Cs-NP's success in decreasing the clotting time for healthy and diabetic blood acting as a procoagulant agent while adding biogenic CuO-NP’s to Cs-NP’s increased clotting time considering as an anti-coagulant agent for hypercholesteremia blood samples.
format	article
author	Somia B. Ahmed Hadeer I. Mohamed Abeer M. Al-Subaie Ahoud I. Al-Ohali Nesrine M. R. Mahmoud
author_facet	Somia B. Ahmed Hadeer I. Mohamed Abeer M. Al-Subaie Ahoud I. Al-Ohali Nesrine M. R. Mahmoud
author_sort	Somia B. Ahmed
title	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite
title_short	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite
title_full	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite
title_fullStr	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite
title_full_unstemmed	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite
title_sort	investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2ac58b060cf04240b1455829f9009213
work_keys_str_mv	AT somiabahmed investigationoftheantimicrobialactivityandhematologicalpatternofnanochitosananditsnanocoppercomposite AT hadeerimohamed investigationoftheantimicrobialactivityandhematologicalpatternofnanochitosananditsnanocoppercomposite AT abeermalsubaie investigationoftheantimicrobialactivityandhematologicalpatternofnanochitosananditsnanocoppercomposite AT ahoudialohali investigationoftheantimicrobialactivityandhematologicalpatternofnanochitosananditsnanocoppercomposite AT nesrinemrmahmoud investigationoftheantimicrobialactivityandhematologicalpatternofnanochitosananditsnanocoppercomposite
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Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite

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