Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice

Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice

Ilaria Bertocchi et al. use a mouse model of Grin2a dysfunction to show that activity-independent NMDA receptors are involved in audiogenic seizure generation. Their results suggest a role for NMDA receptors in maintaining an appropriate response to sensory stimuli and a potential mechanism for dise...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ilaria Bertocchi, Ahmed Eltokhi, Andrey Rozov, Vivan Nguyễn Chi, Vidar Jensen, Thorsten Bus, Verena Pawlak, Marta Serafino, Hannah Sonntag, Boyi Yang, Nail Burnashev, Shi-Bin Li, Horst A. Obenhaus, Martin Both, Burkhard Niewoehner, Frank N. Single, Michael Briese, Thomas Boerner, Peter Gass, John Nick P. Rawlins, Georg Köhr, David M. Bannerman, Rolf Sprengel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/2aca38124f6b4bf6abea581f18e3486f
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:2aca38124f6b4bf6abea581f18e3486f
record_format dspace
spelling oai:doaj.org-article:2aca38124f6b4bf6abea581f18e3486f2021-12-02T15:13:06ZVoltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice10.1038/s42003-020-01538-42399-3642https://doaj.org/article/2aca38124f6b4bf6abea581f18e3486f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01538-4https://doaj.org/toc/2399-3642Ilaria Bertocchi et al. use a mouse model of Grin2a dysfunction to show that activity-independent NMDA receptors are involved in audiogenic seizure generation. Their results suggest a role for NMDA receptors in maintaining an appropriate response to sensory stimuli and a potential mechanism for disease phenotypes in epilepsy patients with GRIN2A mutations.Ilaria BertocchiAhmed EltokhiAndrey RozovVivan Nguyễn ChiVidar JensenThorsten BusVerena PawlakMarta SerafinoHannah SonntagBoyi YangNail BurnashevShi-Bin LiHorst A. ObenhausMartin BothBurkhard NiewoehnerFrank N. SingleMichael BrieseThomas BoernerPeter GassJohn Nick P. RawlinsGeorg KöhrDavid M. BannermanRolf SprengelNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-21 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Ilaria Bertocchi
Ahmed Eltokhi
Andrey Rozov
Vivan Nguyễn Chi
Vidar Jensen
Thorsten Bus
Verena Pawlak
Marta Serafino
Hannah Sonntag
Boyi Yang
Nail Burnashev
Shi-Bin Li
Horst A. Obenhaus
Martin Both
Burkhard Niewoehner
Frank N. Single
Michael Briese
Thomas Boerner
Peter Gass
John Nick P. Rawlins
Georg Köhr
David M. Bannerman
Rolf Sprengel
Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice
description Ilaria Bertocchi et al. use a mouse model of Grin2a dysfunction to show that activity-independent NMDA receptors are involved in audiogenic seizure generation. Their results suggest a role for NMDA receptors in maintaining an appropriate response to sensory stimuli and a potential mechanism for disease phenotypes in epilepsy patients with GRIN2A mutations.
format article
author Ilaria Bertocchi
Ahmed Eltokhi
Andrey Rozov
Vivan Nguyễn Chi
Vidar Jensen
Thorsten Bus
Verena Pawlak
Marta Serafino
Hannah Sonntag
Boyi Yang
Nail Burnashev
Shi-Bin Li
Horst A. Obenhaus
Martin Both
Burkhard Niewoehner
Frank N. Single
Michael Briese
Thomas Boerner
Peter Gass
John Nick P. Rawlins
Georg Köhr
David M. Bannerman
Rolf Sprengel
author_facet Ilaria Bertocchi
Ahmed Eltokhi
Andrey Rozov
Vivan Nguyễn Chi
Vidar Jensen
Thorsten Bus
Verena Pawlak
Marta Serafino
Hannah Sonntag
Boyi Yang
Nail Burnashev
Shi-Bin Li
Horst A. Obenhaus
Martin Both
Burkhard Niewoehner
Frank N. Single
Michael Briese
Thomas Boerner
Peter Gass
John Nick P. Rawlins
Georg Köhr
David M. Bannerman
Rolf Sprengel
author_sort Ilaria Bertocchi
title Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice
title_short Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice
title_full Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice
title_fullStr Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice
title_full_unstemmed Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice
title_sort voltage-independent glun2a-type nmda receptor ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2aca38124f6b4bf6abea581f18e3486f
work_keys_str_mv AT ilariabertocchi voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT ahmedeltokhi voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT andreyrozov voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT vivannguyenchi voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT vidarjensen voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT thorstenbus voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT verenapawlak voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT martaserafino voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT hannahsonntag voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT boyiyang voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT nailburnashev voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT shibinli voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT horstaobenhaus voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT martinboth voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT burkhardniewoehner voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT franknsingle voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT michaelbriese voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT thomasboerner voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT petergass voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT johnnickprawlins voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT georgkohr voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT davidmbannerman voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
AT rolfsprengel voltageindependentglun2atypenmdareceptorca2signalingpromotesaudiogenicseizuresattentionalandcognitivedeficitsinmice
_version_ 1718387558611681280

Ejemplares similares