Polygenic hazard score is associated with prostate cancer in multi-ethnic populations

A polygenic hazard score (PHS1) improves prostate cancer screening accuracy in European patients. Here, the authors test the performance of a version compatible with OncoArray genotypes (PHS2) in a multi-ethnic dataset and find that it risk-stratifies men for any, aggressive, and fatal prostate canc...

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Autores principales:	Minh-Phuong Huynh-Le, Chun Chieh Fan, Roshan Karunamuni, Wesley K. Thompson, Maria Elena Martinez, Rosalind A. Eeles, Zsofia Kote-Jarai, Kenneth Muir, Johanna Schleutker, Nora Pashayan, Jyotsna Batra, Henrik Grönberg, David E. Neal, Jenny L. Donovan, Freddie C. Hamdy, Richard M. Martin, Sune F. Nielsen, Børge G. Nordestgaard, Fredrik Wiklund, Catherine M. Tangen, Graham G. Giles, Alicja Wolk, Demetrius Albanes, Ruth C. Travis, William J. Blot, Wei Zheng, Maureen Sanderson, Janet L. Stanford, Lorelei A. Mucci, Catharine M. L. West, Adam S. Kibel, Olivier Cussenot, Sonja I. Berndt, Stella Koutros, Karina Dalsgaard Sørensen, Cezary Cybulski, Eli Marie Grindedal, Florence Menegaux, Kay-Tee Khaw, Jong Y. Park, Sue A. Ingles, Christiane Maier, Robert J. Hamilton, Stephen N. Thibodeau, Barry S. Rosenstein, Yong-Jie Lu, Stephen Watya, Ana Vega, Manolis Kogevinas, Kathryn L. Penney, Chad Huff, Manuel R. Teixeira, Luc Multigner, Robin J. Leach, Lisa Cannon-Albright, Hermann Brenner, Esther M. John, Radka Kaneva, Christopher J. Logothetis, Susan L. Neuhausen, Kim De Ruyck, Hardev Pandha, Azad Razack, Lisa F. Newcomb, Jay H. Fowke, Marija Gamulin, Nawaid Usmani, Frank Claessens, Manuela Gago-Dominguez, Paul A. Townsend, William S. Bush, Monique J. Roobol, Marie-Élise Parent, Jennifer J. Hu, Ian G. Mills, Ole A. Andreassen, Anders M. Dale, Tyler M. Seibert, UKGPCS collaborators, APCB (Australian Prostate Cancer BioResource), NC-LA PCaP Investigators, The IMPACT Study Steering Committee and Collaborators, Canary PASS Investigators, The Profile Study Steering Committee, The PRACTICAL Consortium
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2acc58dd13bb4c07abb40966fce96b6f
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spelling	oai:doaj.org-article:2acc58dd13bb4c07abb40966fce96b6f2021-12-02T10:59:14ZPolygenic hazard score is associated with prostate cancer in multi-ethnic populations10.1038/s41467-021-21287-02041-1723https://doaj.org/article/2acc58dd13bb4c07abb40966fce96b6f2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21287-0https://doaj.org/toc/2041-1723A polygenic hazard score (PHS1) improves prostate cancer screening accuracy in European patients. Here, the authors test the performance of a version compatible with OncoArray genotypes (PHS2) in a multi-ethnic dataset and find that it risk-stratifies men for any, aggressive, and fatal prostate cancer.Minh-Phuong Huynh-LeChun Chieh FanRoshan KarunamuniWesley K. ThompsonMaria Elena MartinezRosalind A. EelesZsofia Kote-JaraiKenneth MuirJohanna SchleutkerNora PashayanJyotsna BatraHenrik GrönbergDavid E. NealJenny L. DonovanFreddie C. HamdyRichard M. MartinSune F. NielsenBørge G. NordestgaardFredrik WiklundCatherine M. TangenGraham G. GilesAlicja WolkDemetrius AlbanesRuth C. TravisWilliam J. BlotWei ZhengMaureen SandersonJanet L. StanfordLorelei A. MucciCatharine M. L. WestAdam S. KibelOlivier CussenotSonja I. BerndtStella KoutrosKarina Dalsgaard SørensenCezary CybulskiEli Marie GrindedalFlorence MenegauxKay-Tee KhawJong Y. ParkSue A. InglesChristiane MaierRobert J. HamiltonStephen N. ThibodeauBarry S. RosensteinYong-Jie LuStephen WatyaAna VegaManolis KogevinasKathryn L. PenneyChad HuffManuel R. TeixeiraLuc MultignerRobin J. LeachLisa Cannon-AlbrightHermann BrennerEsther M. JohnRadka KanevaChristopher J. LogothetisSusan L. NeuhausenKim De RuyckHardev PandhaAzad RazackLisa F. NewcombJay H. FowkeMarija GamulinNawaid UsmaniFrank ClaessensManuela Gago-DominguezPaul A. TownsendWilliam S. BushMonique J. RoobolMarie-Élise ParentJennifer J. HuIan G. MillsOle A. AndreassenAnders M. DaleTyler M. SeibertUKGPCS collaboratorsAPCB (Australian Prostate Cancer BioResource)NC-LA PCaP InvestigatorsThe IMPACT Study Steering Committee and CollaboratorsCanary PASS InvestigatorsThe Profile Study Steering CommitteeThe PRACTICAL ConsortiumNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Minh-Phuong Huynh-Le Chun Chieh Fan Roshan Karunamuni Wesley K. Thompson Maria Elena Martinez Rosalind A. Eeles Zsofia Kote-Jarai Kenneth Muir Johanna Schleutker Nora Pashayan Jyotsna Batra Henrik Grönberg David E. Neal Jenny L. Donovan Freddie C. Hamdy Richard M. Martin Sune F. Nielsen Børge G. Nordestgaard Fredrik Wiklund Catherine M. Tangen Graham G. Giles Alicja Wolk Demetrius Albanes Ruth C. Travis William J. Blot Wei Zheng Maureen Sanderson Janet L. Stanford Lorelei A. Mucci Catharine M. L. West Adam S. Kibel Olivier Cussenot Sonja I. Berndt Stella Koutros Karina Dalsgaard Sørensen Cezary Cybulski Eli Marie Grindedal Florence Menegaux Kay-Tee Khaw Jong Y. Park Sue A. Ingles Christiane Maier Robert J. Hamilton Stephen N. Thibodeau Barry S. Rosenstein Yong-Jie Lu Stephen Watya Ana Vega Manolis Kogevinas Kathryn L. Penney Chad Huff Manuel R. Teixeira Luc Multigner Robin J. Leach Lisa Cannon-Albright Hermann Brenner Esther M. John Radka Kaneva Christopher J. Logothetis Susan L. Neuhausen Kim De Ruyck Hardev Pandha Azad Razack Lisa F. Newcomb Jay H. Fowke Marija Gamulin Nawaid Usmani Frank Claessens Manuela Gago-Dominguez Paul A. Townsend William S. Bush Monique J. Roobol Marie-Élise Parent Jennifer J. Hu Ian G. Mills Ole A. Andreassen Anders M. Dale Tyler M. Seibert UKGPCS collaborators APCB (Australian Prostate Cancer BioResource) NC-LA PCaP Investigators The IMPACT Study Steering Committee and Collaborators Canary PASS Investigators The Profile Study Steering Committee The PRACTICAL Consortium Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
description	A polygenic hazard score (PHS1) improves prostate cancer screening accuracy in European patients. Here, the authors test the performance of a version compatible with OncoArray genotypes (PHS2) in a multi-ethnic dataset and find that it risk-stratifies men for any, aggressive, and fatal prostate cancer.
format	article
author	Minh-Phuong Huynh-Le Chun Chieh Fan Roshan Karunamuni Wesley K. Thompson Maria Elena Martinez Rosalind A. Eeles Zsofia Kote-Jarai Kenneth Muir Johanna Schleutker Nora Pashayan Jyotsna Batra Henrik Grönberg David E. Neal Jenny L. Donovan Freddie C. Hamdy Richard M. Martin Sune F. Nielsen Børge G. Nordestgaard Fredrik Wiklund Catherine M. Tangen Graham G. Giles Alicja Wolk Demetrius Albanes Ruth C. Travis William J. Blot Wei Zheng Maureen Sanderson Janet L. Stanford Lorelei A. Mucci Catharine M. L. West Adam S. Kibel Olivier Cussenot Sonja I. Berndt Stella Koutros Karina Dalsgaard Sørensen Cezary Cybulski Eli Marie Grindedal Florence Menegaux Kay-Tee Khaw Jong Y. Park Sue A. Ingles Christiane Maier Robert J. Hamilton Stephen N. Thibodeau Barry S. Rosenstein Yong-Jie Lu Stephen Watya Ana Vega Manolis Kogevinas Kathryn L. Penney Chad Huff Manuel R. Teixeira Luc Multigner Robin J. Leach Lisa Cannon-Albright Hermann Brenner Esther M. John Radka Kaneva Christopher J. Logothetis Susan L. Neuhausen Kim De Ruyck Hardev Pandha Azad Razack Lisa F. Newcomb Jay H. Fowke Marija Gamulin Nawaid Usmani Frank Claessens Manuela Gago-Dominguez Paul A. Townsend William S. Bush Monique J. Roobol Marie-Élise Parent Jennifer J. Hu Ian G. Mills Ole A. Andreassen Anders M. Dale Tyler M. Seibert UKGPCS collaborators APCB (Australian Prostate Cancer BioResource) NC-LA PCaP Investigators The IMPACT Study Steering Committee and Collaborators Canary PASS Investigators The Profile Study Steering Committee The PRACTICAL Consortium
author_facet	Minh-Phuong Huynh-Le Chun Chieh Fan Roshan Karunamuni Wesley K. Thompson Maria Elena Martinez Rosalind A. Eeles Zsofia Kote-Jarai Kenneth Muir Johanna Schleutker Nora Pashayan Jyotsna Batra Henrik Grönberg David E. Neal Jenny L. Donovan Freddie C. Hamdy Richard M. Martin Sune F. Nielsen Børge G. Nordestgaard Fredrik Wiklund Catherine M. Tangen Graham G. Giles Alicja Wolk Demetrius Albanes Ruth C. Travis William J. Blot Wei Zheng Maureen Sanderson Janet L. Stanford Lorelei A. Mucci Catharine M. L. West Adam S. Kibel Olivier Cussenot Sonja I. Berndt Stella Koutros Karina Dalsgaard Sørensen Cezary Cybulski Eli Marie Grindedal Florence Menegaux Kay-Tee Khaw Jong Y. Park Sue A. Ingles Christiane Maier Robert J. Hamilton Stephen N. Thibodeau Barry S. Rosenstein Yong-Jie Lu Stephen Watya Ana Vega Manolis Kogevinas Kathryn L. Penney Chad Huff Manuel R. Teixeira Luc Multigner Robin J. Leach Lisa Cannon-Albright Hermann Brenner Esther M. John Radka Kaneva Christopher J. Logothetis Susan L. Neuhausen Kim De Ruyck Hardev Pandha Azad Razack Lisa F. Newcomb Jay H. Fowke Marija Gamulin Nawaid Usmani Frank Claessens Manuela Gago-Dominguez Paul A. Townsend William S. Bush Monique J. Roobol Marie-Élise Parent Jennifer J. Hu Ian G. Mills Ole A. Andreassen Anders M. Dale Tyler M. Seibert UKGPCS collaborators APCB (Australian Prostate Cancer BioResource) NC-LA PCaP Investigators The IMPACT Study Steering Committee and Collaborators Canary PASS Investigators The Profile Study Steering Committee The PRACTICAL Consortium
author_sort	Minh-Phuong Huynh-Le
title	Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
title_short	Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
title_full	Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
title_fullStr	Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
title_full_unstemmed	Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
title_sort	polygenic hazard score is associated with prostate cancer in multi-ethnic populations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2acc58dd13bb4c07abb40966fce96b6f
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Polygenic hazard score is associated with prostate cancer in multi-ethnic populations

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