Hydrogen peroxide release by bacteria suppresses inflammasome-dependent innate immunity

The functions of microbial hydrogen peroxide (H2O2) in host-pathogen interactions are unclear. Here, Erttmann and Gekara show that H2O2 released by Streptococcus pneumoniae inhibits inflammasomes, and thereby contributes to the pathogen’s ability to colonize the host.

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Detalles Bibliográficos
Autores principales: Saskia F. Erttmann, Nelson O. Gekara
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/2ad1f8e2c0c84d7d9d050f990faeb40e
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Descripción
Sumario:The functions of microbial hydrogen peroxide (H2O2) in host-pathogen interactions are unclear. Here, Erttmann and Gekara show that H2O2 released by Streptococcus pneumoniae inhibits inflammasomes, and thereby contributes to the pathogen’s ability to colonize the host.