Magnetic multiwalled carbon nanotubes with controlled release of epirubicin: an intravesical instillation system for bladder cancer

Ning Suo,1 Muwen Wang,1 Yang Jin,1 Jun Ding,2 Xueping Gao,3 Xiaoliang Sun,1 Haiyang Zhang,1 Meng Cui,4 Jilu Zheng,1 Nianlu Li,5 Xunbo Jin,1,* Shaobo Jiang1,* 1Department of Urology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China; 2Department of Mechanical Engine...

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Autores principales:	Suo N, Wang M, Jin Y, Ding J, Gao X, Sun X, Zhang H, Cui M, Zheng J, Li N, Jin X, Jiang S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	magnetic multiwalled carbon nanotubes intravesical instillation epirubincin intravesical drug delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2ad2987d14a249d794e899f4ce76f20e
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spelling	oai:doaj.org-article:2ad2987d14a249d794e899f4ce76f20e2021-12-02T02:35:15ZMagnetic multiwalled carbon nanotubes with controlled release of epirubicin: an intravesical instillation system for bladder cancer1178-2013https://doaj.org/article/2ad2987d14a249d794e899f4ce76f20e2019-02-01T00:00:00Zhttps://www.dovepress.com/magnetic-multiwalled-carbon-nanotubes-with-controlled-release-of-epiru-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ning Suo,1 Muwen Wang,1 Yang Jin,1 Jun Ding,2 Xueping Gao,3 Xiaoliang Sun,1 Haiyang Zhang,1 Meng Cui,4 Jilu Zheng,1 Nianlu Li,5 Xunbo Jin,1,* Shaobo Jiang1,* 1Department of Urology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China; 2Department of Mechanical Engineering, University of Maryland, Baltimore County, Baltimore, MD, 21250, USA; 3School of Material Science and Engineering, Shandong University, Jinan 250100, China; 4Department of Urology, Shandong Provincial Maternity and Childcare Hospital, Jinan 250014, China; 5School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China *These authors contributed equally to this work Background: Traditional intravesical instillation treatment in bladder cancer has limited efficacy, which results in a high frequency of recurrence.Purpose: The aim of this study was to report on an epirubicin (EPI)-loaded magnetic multiwalled carbon nanotube (mMWCNTs-EPI) system for intravesical instillation in place of the current formulation.Methods: The mMWCNTs-EPI system was formulated with carboxylated MWCNTs, Fe3O4 magnetic nanoparticles, and EPI. Features and antitumor activity of the system were investigated.Results: Under the effect of external magnets, the mMWCNTs-EPI system showed sustained release and prolonged retention behavior and better antitumor activity than free EPI. The mMWCNTs-EPI system had higher efficiency in enhancing cytotoxicity and inhibiting proliferation in vitro and in vivo than free EPI. Our studies also revealed the atoxic nature of mMWCNTs.Conclusion: These findings suggested that mMWCNTs are effective intravesical instillation agents with great potential for clinical application. Keywords: carbon nanotubes, intravesical instillation, epirubicin, intravesical drug deliverySuo NWang MJin YDing JGao XSun XZhang HCui MZheng JLi NJin XJiang SDove Medical Pressarticlemagnetic multiwalled carbon nanotubesintravesical instillationepirubincinintravesical drug deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 1241-1254 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnetic multiwalled carbon nanotubes intravesical instillation epirubincin intravesical drug delivery Medicine (General) R5-920
spellingShingle	magnetic multiwalled carbon nanotubes intravesical instillation epirubincin intravesical drug delivery Medicine (General) R5-920 Suo N Wang M Jin Y Ding J Gao X Sun X Zhang H Cui M Zheng J Li N Jin X Jiang S Magnetic multiwalled carbon nanotubes with controlled release of epirubicin: an intravesical instillation system for bladder cancer
description	Ning Suo,1 Muwen Wang,1 Yang Jin,1 Jun Ding,2 Xueping Gao,3 Xiaoliang Sun,1 Haiyang Zhang,1 Meng Cui,4 Jilu Zheng,1 Nianlu Li,5 Xunbo Jin,1,* Shaobo Jiang1,* 1Department of Urology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China; 2Department of Mechanical Engineering, University of Maryland, Baltimore County, Baltimore, MD, 21250, USA; 3School of Material Science and Engineering, Shandong University, Jinan 250100, China; 4Department of Urology, Shandong Provincial Maternity and Childcare Hospital, Jinan 250014, China; 5School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China *These authors contributed equally to this work Background: Traditional intravesical instillation treatment in bladder cancer has limited efficacy, which results in a high frequency of recurrence.Purpose: The aim of this study was to report on an epirubicin (EPI)-loaded magnetic multiwalled carbon nanotube (mMWCNTs-EPI) system for intravesical instillation in place of the current formulation.Methods: The mMWCNTs-EPI system was formulated with carboxylated MWCNTs, Fe3O4 magnetic nanoparticles, and EPI. Features and antitumor activity of the system were investigated.Results: Under the effect of external magnets, the mMWCNTs-EPI system showed sustained release and prolonged retention behavior and better antitumor activity than free EPI. The mMWCNTs-EPI system had higher efficiency in enhancing cytotoxicity and inhibiting proliferation in vitro and in vivo than free EPI. Our studies also revealed the atoxic nature of mMWCNTs.Conclusion: These findings suggested that mMWCNTs are effective intravesical instillation agents with great potential for clinical application. Keywords: carbon nanotubes, intravesical instillation, epirubicin, intravesical drug delivery
format	article
author	Suo N Wang M Jin Y Ding J Gao X Sun X Zhang H Cui M Zheng J Li N Jin X Jiang S
author_facet	Suo N Wang M Jin Y Ding J Gao X Sun X Zhang H Cui M Zheng J Li N Jin X Jiang S
author_sort	Suo N
title	Magnetic multiwalled carbon nanotubes with controlled release of epirubicin: an intravesical instillation system for bladder cancer
title_short	Magnetic multiwalled carbon nanotubes with controlled release of epirubicin: an intravesical instillation system for bladder cancer
title_full	Magnetic multiwalled carbon nanotubes with controlled release of epirubicin: an intravesical instillation system for bladder cancer
title_fullStr	Magnetic multiwalled carbon nanotubes with controlled release of epirubicin: an intravesical instillation system for bladder cancer
title_full_unstemmed	Magnetic multiwalled carbon nanotubes with controlled release of epirubicin: an intravesical instillation system for bladder cancer
title_sort	magnetic multiwalled carbon nanotubes with controlled release of epirubicin: an intravesical instillation system for bladder cancer
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/2ad2987d14a249d794e899f4ce76f20e
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Magnetic multiwalled carbon nanotubes with controlled release of epirubicin: an intravesical instillation system for bladder cancer

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