Feed additives for the control of post-weaning Streptococcus suis disease and the effect on the faecal and nasal microbiota

Abstract Medicated feed is a common strategy to control the occurrence of Streptococcus suis disease in swine production, but feed additives may constitute an alternative to metaphylaxis. In a farm with post-weaning S. suis disease, the following additives were tested: lysozyme (Lys), medium chain f...

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Autores principales:	Florencia Correa-Fiz, Carlos Neila-Ibáñez, Sergio López-Soria, Sebastian Napp, Blanca Martinez, Laia Sobrevia, Simon Tibble, Virginia Aragon, Lourdes Migura-Garcia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2ad2ad94d62743639a465a285bfe0612
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spelling	oai:doaj.org-article:2ad2ad94d62743639a465a285bfe06122021-12-02T11:42:10ZFeed additives for the control of post-weaning Streptococcus suis disease and the effect on the faecal and nasal microbiota10.1038/s41598-020-77313-62045-2322https://doaj.org/article/2ad2ad94d62743639a465a285bfe06122020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77313-6https://doaj.org/toc/2045-2322Abstract Medicated feed is a common strategy to control the occurrence of Streptococcus suis disease in swine production, but feed additives may constitute an alternative to metaphylaxis. In a farm with post-weaning S. suis disease, the following additives were tested: lysozyme (Lys), medium chain fatty acids plus lysozyme (FA + Lys), FA plus a natural anti-inflammatory (FA + antiinf) and amoxicillin (Amox). During the course of the study, FA + antiinf and Amox groups showed lower prevalence of clinical signs compatible with S. suis disease than the rest of the groups. Piglets from the FA + antiinf group showed high diversity and richness in their nasal and faecal microbiota. Diet supplements did not have major effects on the faecal microbiota, where the genus Mitsuokella was the only differentially present in the FA + Lys group. In the nasal microbiota, piglets from FA + antiinf presented higher differential abundance of a sequence variant from Ruminococcaceae and lower abundance of an unclassified genus from Weeksellaceae. In general, we detected more significant changes in the nasal than in the feacal microbiota, and found that parity of the dams affected the microbiota composition of their offspring, with piglets born to gilts exhibiting lower richness and diversity. Our results suggest that additives could be useful to control post-weaning disease when removing antimicrobials in farms.Florencia Correa-FizCarlos Neila-IbáñezSergio López-SoriaSebastian NappBlanca MartinezLaia SobreviaSimon TibbleVirginia AragonLourdes Migura-GarciaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Florencia Correa-Fiz Carlos Neila-Ibáñez Sergio López-Soria Sebastian Napp Blanca Martinez Laia Sobrevia Simon Tibble Virginia Aragon Lourdes Migura-Garcia Feed additives for the control of post-weaning Streptococcus suis disease and the effect on the faecal and nasal microbiota
description	Abstract Medicated feed is a common strategy to control the occurrence of Streptococcus suis disease in swine production, but feed additives may constitute an alternative to metaphylaxis. In a farm with post-weaning S. suis disease, the following additives were tested: lysozyme (Lys), medium chain fatty acids plus lysozyme (FA + Lys), FA plus a natural anti-inflammatory (FA + antiinf) and amoxicillin (Amox). During the course of the study, FA + antiinf and Amox groups showed lower prevalence of clinical signs compatible with S. suis disease than the rest of the groups. Piglets from the FA + antiinf group showed high diversity and richness in their nasal and faecal microbiota. Diet supplements did not have major effects on the faecal microbiota, where the genus Mitsuokella was the only differentially present in the FA + Lys group. In the nasal microbiota, piglets from FA + antiinf presented higher differential abundance of a sequence variant from Ruminococcaceae and lower abundance of an unclassified genus from Weeksellaceae. In general, we detected more significant changes in the nasal than in the feacal microbiota, and found that parity of the dams affected the microbiota composition of their offspring, with piglets born to gilts exhibiting lower richness and diversity. Our results suggest that additives could be useful to control post-weaning disease when removing antimicrobials in farms.
format	article
author	Florencia Correa-Fiz Carlos Neila-Ibáñez Sergio López-Soria Sebastian Napp Blanca Martinez Laia Sobrevia Simon Tibble Virginia Aragon Lourdes Migura-Garcia
author_facet	Florencia Correa-Fiz Carlos Neila-Ibáñez Sergio López-Soria Sebastian Napp Blanca Martinez Laia Sobrevia Simon Tibble Virginia Aragon Lourdes Migura-Garcia
author_sort	Florencia Correa-Fiz
title	Feed additives for the control of post-weaning Streptococcus suis disease and the effect on the faecal and nasal microbiota
title_short	Feed additives for the control of post-weaning Streptococcus suis disease and the effect on the faecal and nasal microbiota
title_full	Feed additives for the control of post-weaning Streptococcus suis disease and the effect on the faecal and nasal microbiota
title_fullStr	Feed additives for the control of post-weaning Streptococcus suis disease and the effect on the faecal and nasal microbiota
title_full_unstemmed	Feed additives for the control of post-weaning Streptococcus suis disease and the effect on the faecal and nasal microbiota
title_sort	feed additives for the control of post-weaning streptococcus suis disease and the effect on the faecal and nasal microbiota
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2ad2ad94d62743639a465a285bfe0612
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Feed additives for the control of post-weaning Streptococcus suis disease and the effect on the faecal and nasal microbiota

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