Direct neurotransmitter activation of voltage-gated potassium channels

M-current is conveyed by voltage-sensitive KCNQ channels, which are enriched in GABAergic neurons and are activated by anticonvulsants such as retigabine. Here the authors show that GABA directly activates KCNQ3, at the residue required for its anticonvulsant activity.

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Auteurs principaux:	Rían W. Manville, Maria Papanikolaou, Geoffrey W. Abbott
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/2ad40d9af26245ef824e15348a069d8d
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id	oai:doaj.org-article:2ad40d9af26245ef824e15348a069d8d
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spelling	oai:doaj.org-article:2ad40d9af26245ef824e15348a069d8d2021-12-02T14:41:06ZDirect neurotransmitter activation of voltage-gated potassium channels10.1038/s41467-018-04266-w2041-1723https://doaj.org/article/2ad40d9af26245ef824e15348a069d8d2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04266-whttps://doaj.org/toc/2041-1723M-current is conveyed by voltage-sensitive KCNQ channels, which are enriched in GABAergic neurons and are activated by anticonvulsants such as retigabine. Here the authors show that GABA directly activates KCNQ3, at the residue required for its anticonvulsant activity.Rían W. ManvilleMaria PapanikolaouGeoffrey W. AbbottNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rían W. Manville Maria Papanikolaou Geoffrey W. Abbott Direct neurotransmitter activation of voltage-gated potassium channels
description	M-current is conveyed by voltage-sensitive KCNQ channels, which are enriched in GABAergic neurons and are activated by anticonvulsants such as retigabine. Here the authors show that GABA directly activates KCNQ3, at the residue required for its anticonvulsant activity.
format	article
author	Rían W. Manville Maria Papanikolaou Geoffrey W. Abbott
author_facet	Rían W. Manville Maria Papanikolaou Geoffrey W. Abbott
author_sort	Rían W. Manville
title	Direct neurotransmitter activation of voltage-gated potassium channels
title_short	Direct neurotransmitter activation of voltage-gated potassium channels
title_full	Direct neurotransmitter activation of voltage-gated potassium channels
title_fullStr	Direct neurotransmitter activation of voltage-gated potassium channels
title_full_unstemmed	Direct neurotransmitter activation of voltage-gated potassium channels
title_sort	direct neurotransmitter activation of voltage-gated potassium channels
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2ad40d9af26245ef824e15348a069d8d
work_keys_str_mv	AT rianwmanville directneurotransmitteractivationofvoltagegatedpotassiumchannels AT mariapapanikolaou directneurotransmitteractivationofvoltagegatedpotassiumchannels AT geoffreywabbott directneurotransmitteractivationofvoltagegatedpotassiumchannels
_version_	1718389980756180992

Direct neurotransmitter activation of voltage-gated potassium channels

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