Long-term changes of retinal pigment epithelium in the eyes with Vogt-Koyanagi-Harada disease observed by adaptive optics imaging

Tomoko Nakamura, Atsushi Hayashi, Toshihiko OiwakeDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, JapanPurpose: To observe long-term changes of the retinal pigment epithelium (RPE) in the eyes of patients with Vogt-Koyanagi-Harada (...

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Autores principales:	Nakamura T, Hayashi A, Oiwake T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	adaptive optics fundus autofluorescence near-infrared imaging Vogt-Koyanagi-Harada disease retinal pigment epithelium Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/2ad50ae8d20f41ab93cc0b5af64a887b
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spelling	oai:doaj.org-article:2ad50ae8d20f41ab93cc0b5af64a887b2021-12-02T09:30:40ZLong-term changes of retinal pigment epithelium in the eyes with Vogt-Koyanagi-Harada disease observed by adaptive optics imaging1177-5483https://doaj.org/article/2ad50ae8d20f41ab93cc0b5af64a887b2019-05-01T00:00:00Zhttps://www.dovepress.com/long-term-changes-of-retinal-pigment-epithelium-in-the-eyes-with-vogt--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Tomoko Nakamura, Atsushi Hayashi, Toshihiko OiwakeDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, JapanPurpose: To observe long-term changes of the retinal pigment epithelium (RPE) in the eyes of patients with Vogt-Koyanagi-Harada (VKH) disease using an adaptive optics (AO) fundus camera, and their correlation with the findings of spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (AF) imaging.Patients and methods: Three eyes of two patients with new-onset acute VKH disease were retrospectively studied. After the serous retinal detachment was resolved by high-dose corticosteroid treatment, the patients were examined with SD-OCT, blue-wavelength AF, near-infrared (NIR) AF, and an AO fundus camera. AO images of the macula were obtained using the rtx1TM, AO fundus camera. The area around the foveal center of the hyper-reflective lesion in AO imaging was measured manually. The time at which the serous retinal detachment resolved was set as the baseline, and AO and other images were obtained every 3 to 6 months from the baseline.Results: In all three eyes, lesions with elevation or thickening of the RPE layer were observed with OCT imaging in the macula after the serous retinal detachment resolved. These lesions showed hyper-autofluorescence in NIR-AF image and hyper-reflective lesions with clear boundaries in AO image. The area of the hyper-reflective lesions of AO images in each eye showed an approximately 40% decrease at 6 months from baseline. However, the hyper-reflective lesion remained to some extent after 18 months in case 1 and 36 months in case 2.Conclusions: By using OCT, fundus autofluorescence and AO images, it was possible to observe temporal changes of RPE layer in VKH eyes noninvasively. High-resolution AO images also allow us to observe for improvements in the elevation or thickening of the RPE layer quantitatively.Keywords: adaptive optics, fundus autofluorescence, near-infrared imaging, Vogt-Koyanagi-Harada disease, retinal pigment epitheliumNakamura THayashi AOiwake TDove Medical Pressarticleadaptive opticsfundus autofluorescencenear-infrared imagingVogt-Koyanagi-Harada diseaseretinal pigment epitheliumOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 927-933 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	adaptive optics fundus autofluorescence near-infrared imaging Vogt-Koyanagi-Harada disease retinal pigment epithelium Ophthalmology RE1-994
spellingShingle	adaptive optics fundus autofluorescence near-infrared imaging Vogt-Koyanagi-Harada disease retinal pigment epithelium Ophthalmology RE1-994 Nakamura T Hayashi A Oiwake T Long-term changes of retinal pigment epithelium in the eyes with Vogt-Koyanagi-Harada disease observed by adaptive optics imaging
description	Tomoko Nakamura, Atsushi Hayashi, Toshihiko OiwakeDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, JapanPurpose: To observe long-term changes of the retinal pigment epithelium (RPE) in the eyes of patients with Vogt-Koyanagi-Harada (VKH) disease using an adaptive optics (AO) fundus camera, and their correlation with the findings of spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (AF) imaging.Patients and methods: Three eyes of two patients with new-onset acute VKH disease were retrospectively studied. After the serous retinal detachment was resolved by high-dose corticosteroid treatment, the patients were examined with SD-OCT, blue-wavelength AF, near-infrared (NIR) AF, and an AO fundus camera. AO images of the macula were obtained using the rtx1TM, AO fundus camera. The area around the foveal center of the hyper-reflective lesion in AO imaging was measured manually. The time at which the serous retinal detachment resolved was set as the baseline, and AO and other images were obtained every 3 to 6 months from the baseline.Results: In all three eyes, lesions with elevation or thickening of the RPE layer were observed with OCT imaging in the macula after the serous retinal detachment resolved. These lesions showed hyper-autofluorescence in NIR-AF image and hyper-reflective lesions with clear boundaries in AO image. The area of the hyper-reflective lesions of AO images in each eye showed an approximately 40% decrease at 6 months from baseline. However, the hyper-reflective lesion remained to some extent after 18 months in case 1 and 36 months in case 2.Conclusions: By using OCT, fundus autofluorescence and AO images, it was possible to observe temporal changes of RPE layer in VKH eyes noninvasively. High-resolution AO images also allow us to observe for improvements in the elevation or thickening of the RPE layer quantitatively.Keywords: adaptive optics, fundus autofluorescence, near-infrared imaging, Vogt-Koyanagi-Harada disease, retinal pigment epithelium
format	article
author	Nakamura T Hayashi A Oiwake T
author_facet	Nakamura T Hayashi A Oiwake T
author_sort	Nakamura T
title	Long-term changes of retinal pigment epithelium in the eyes with Vogt-Koyanagi-Harada disease observed by adaptive optics imaging
title_short	Long-term changes of retinal pigment epithelium in the eyes with Vogt-Koyanagi-Harada disease observed by adaptive optics imaging
title_full	Long-term changes of retinal pigment epithelium in the eyes with Vogt-Koyanagi-Harada disease observed by adaptive optics imaging
title_fullStr	Long-term changes of retinal pigment epithelium in the eyes with Vogt-Koyanagi-Harada disease observed by adaptive optics imaging
title_full_unstemmed	Long-term changes of retinal pigment epithelium in the eyes with Vogt-Koyanagi-Harada disease observed by adaptive optics imaging
title_sort	long-term changes of retinal pigment epithelium in the eyes with vogt-koyanagi-harada disease observed by adaptive optics imaging
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/2ad50ae8d20f41ab93cc0b5af64a887b
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Long-term changes of retinal pigment epithelium in the eyes with Vogt-Koyanagi-Harada disease observed by adaptive optics imaging

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