miRNA-Based Regulation of Alternative RNA Splicing in Metazoans

Alternative RNA splicing is an important regulatory process used by genes to increase their diversity. This process is mainly executed by specific classes of RNA binding proteins that act in a dosage-dependent manner to include or exclude selected exons in the final transcripts. While these processe...

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Autores principales:	Anna L. Schorr, Marco Mangone
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	microRNA alternative splicing cancer tissue differentiation SR proteins hnRNPs Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/2ad95b5e421842c6a1fd4d9dac9813db
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spelling	oai:doaj.org-article:2ad95b5e421842c6a1fd4d9dac9813db2021-11-11T17:05:47ZmiRNA-Based Regulation of Alternative RNA Splicing in Metazoans10.3390/ijms2221116181422-00671661-6596https://doaj.org/article/2ad95b5e421842c6a1fd4d9dac9813db2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11618https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Alternative RNA splicing is an important regulatory process used by genes to increase their diversity. This process is mainly executed by specific classes of RNA binding proteins that act in a dosage-dependent manner to include or exclude selected exons in the final transcripts. While these processes are tightly regulated in cells and tissues, little is known on how the dosage of these factors is achieved and maintained. Several recent studies have suggested that alternative RNA splicing may be in part modulated by microRNAs (miRNAs), which are short, non-coding RNAs (~22 nt in length) that inhibit translation of specific mRNA transcripts. As evidenced in tissues and in diseases, such as cancer and neurological disorders, the dysregulation of miRNA pathways disrupts downstream alternative RNA splicing events by altering the dosage of splicing factors involved in RNA splicing. This attractive model suggests that miRNAs can not only influence the dosage of gene expression at the post-transcriptional level but also indirectly interfere in pre-mRNA splicing at the co-transcriptional level. The purpose of this review is to compile and analyze recent studies on miRNAs modulating alternative RNA splicing factors, and how these events contribute to transcript rearrangements in tissue development and disease.Anna L. SchorrMarco MangoneMDPI AGarticlemicroRNAalternative splicingcancertissue differentiationSR proteinshnRNPsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11618, p 11618 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microRNA alternative splicing cancer tissue differentiation SR proteins hnRNPs Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	microRNA alternative splicing cancer tissue differentiation SR proteins hnRNPs Biology (General) QH301-705.5 Chemistry QD1-999 Anna L. Schorr Marco Mangone miRNA-Based Regulation of Alternative RNA Splicing in Metazoans
description	Alternative RNA splicing is an important regulatory process used by genes to increase their diversity. This process is mainly executed by specific classes of RNA binding proteins that act in a dosage-dependent manner to include or exclude selected exons in the final transcripts. While these processes are tightly regulated in cells and tissues, little is known on how the dosage of these factors is achieved and maintained. Several recent studies have suggested that alternative RNA splicing may be in part modulated by microRNAs (miRNAs), which are short, non-coding RNAs (~22 nt in length) that inhibit translation of specific mRNA transcripts. As evidenced in tissues and in diseases, such as cancer and neurological disorders, the dysregulation of miRNA pathways disrupts downstream alternative RNA splicing events by altering the dosage of splicing factors involved in RNA splicing. This attractive model suggests that miRNAs can not only influence the dosage of gene expression at the post-transcriptional level but also indirectly interfere in pre-mRNA splicing at the co-transcriptional level. The purpose of this review is to compile and analyze recent studies on miRNAs modulating alternative RNA splicing factors, and how these events contribute to transcript rearrangements in tissue development and disease.
format	article
author	Anna L. Schorr Marco Mangone
author_facet	Anna L. Schorr Marco Mangone
author_sort	Anna L. Schorr
title	miRNA-Based Regulation of Alternative RNA Splicing in Metazoans
title_short	miRNA-Based Regulation of Alternative RNA Splicing in Metazoans
title_full	miRNA-Based Regulation of Alternative RNA Splicing in Metazoans
title_fullStr	miRNA-Based Regulation of Alternative RNA Splicing in Metazoans
title_full_unstemmed	miRNA-Based Regulation of Alternative RNA Splicing in Metazoans
title_sort	mirna-based regulation of alternative rna splicing in metazoans
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2ad95b5e421842c6a1fd4d9dac9813db
work_keys_str_mv	AT annalschorr mirnabasedregulationofalternativernasplicinginmetazoans AT marcomangone mirnabasedregulationofalternativernasplicinginmetazoans
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miRNA-Based Regulation of Alternative RNA Splicing in Metazoans

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