Some novel antileishmanial compounds inhibit normal cell cycle progression of Leishmania donovani promastigotes and exhibits pro-oxidative potential.

In the midst of numerous setbacks that beclouds the fight against leishmaniasis; a neglected tropical disease, the search for new chemotherapeutics against this disease is of utmost importance. Leishmaniasis is a disease closely associated with poverty and endemic in Africa, Asia, southern Europe an...

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Autores principales:	Wandayi Emmanuel Amlabu, Cynthia Mmalebna Amisigo, Christine Achiaa Antwi, Gordon Akanzuwine Awandare, Theresa Manful Gwira
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2adedd100ce8402e822f33843f2503bb
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spelling	oai:doaj.org-article:2adedd100ce8402e822f33843f2503bb2021-12-02T20:16:17ZSome novel antileishmanial compounds inhibit normal cell cycle progression of Leishmania donovani promastigotes and exhibits pro-oxidative potential.1932-620310.1371/journal.pone.0258996https://doaj.org/article/2adedd100ce8402e822f33843f2503bb2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258996https://doaj.org/toc/1932-6203In the midst of numerous setbacks that beclouds the fight against leishmaniasis; a neglected tropical disease, the search for new chemotherapeutics against this disease is of utmost importance. Leishmaniasis is a disease closely associated with poverty and endemic in Africa, Asia, southern Europe and the Americas. It is caused by parasites of the genus Leishmania and transmitted by a sandfly vector. In this study, we evaluated the antileishmanial potency of eighteen pathogen box compounds and elucidated their biosafety and possible mechanisms of action against Leishmania donovani promastigotes and amastigotes in vitro. IC50s range of 0.12±0.15 to >6.25 μg/ml and 0.13±0.004 to >6.25μg/ml were observed for the promastigotes and amastigotes, respectively. We demonstrated the ability of some of the compounds to cause cytocidal effect on the parasites, induce increased production of reactive oxygen species (ROS), disrupt the normal parasite morphology and cause the accumulation of parasites at the DNA synthesis phase of the cell cycle. We recommend a further in vivo study on these compounds to validate the findings.Wandayi Emmanuel AmlabuCynthia Mmalebna AmisigoChristine Achiaa AntwiGordon Akanzuwine AwandareTheresa Manful GwiraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0258996 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wandayi Emmanuel Amlabu Cynthia Mmalebna Amisigo Christine Achiaa Antwi Gordon Akanzuwine Awandare Theresa Manful Gwira Some novel antileishmanial compounds inhibit normal cell cycle progression of Leishmania donovani promastigotes and exhibits pro-oxidative potential.
description	In the midst of numerous setbacks that beclouds the fight against leishmaniasis; a neglected tropical disease, the search for new chemotherapeutics against this disease is of utmost importance. Leishmaniasis is a disease closely associated with poverty and endemic in Africa, Asia, southern Europe and the Americas. It is caused by parasites of the genus Leishmania and transmitted by a sandfly vector. In this study, we evaluated the antileishmanial potency of eighteen pathogen box compounds and elucidated their biosafety and possible mechanisms of action against Leishmania donovani promastigotes and amastigotes in vitro. IC50s range of 0.12±0.15 to >6.25 μg/ml and 0.13±0.004 to >6.25μg/ml were observed for the promastigotes and amastigotes, respectively. We demonstrated the ability of some of the compounds to cause cytocidal effect on the parasites, induce increased production of reactive oxygen species (ROS), disrupt the normal parasite morphology and cause the accumulation of parasites at the DNA synthesis phase of the cell cycle. We recommend a further in vivo study on these compounds to validate the findings.
format	article
author	Wandayi Emmanuel Amlabu Cynthia Mmalebna Amisigo Christine Achiaa Antwi Gordon Akanzuwine Awandare Theresa Manful Gwira
author_facet	Wandayi Emmanuel Amlabu Cynthia Mmalebna Amisigo Christine Achiaa Antwi Gordon Akanzuwine Awandare Theresa Manful Gwira
author_sort	Wandayi Emmanuel Amlabu
title	Some novel antileishmanial compounds inhibit normal cell cycle progression of Leishmania donovani promastigotes and exhibits pro-oxidative potential.
title_short	Some novel antileishmanial compounds inhibit normal cell cycle progression of Leishmania donovani promastigotes and exhibits pro-oxidative potential.
title_full	Some novel antileishmanial compounds inhibit normal cell cycle progression of Leishmania donovani promastigotes and exhibits pro-oxidative potential.
title_fullStr	Some novel antileishmanial compounds inhibit normal cell cycle progression of Leishmania donovani promastigotes and exhibits pro-oxidative potential.
title_full_unstemmed	Some novel antileishmanial compounds inhibit normal cell cycle progression of Leishmania donovani promastigotes and exhibits pro-oxidative potential.
title_sort	some novel antileishmanial compounds inhibit normal cell cycle progression of leishmania donovani promastigotes and exhibits pro-oxidative potential.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/2adedd100ce8402e822f33843f2503bb
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Some novel antileishmanial compounds inhibit normal cell cycle progression of Leishmania donovani promastigotes and exhibits pro-oxidative potential.

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