Magnetic particle imaging: kinetics of the intravascular signal in vivo

Julian Haegele,1 Robert L Duschka,1 Matthias Graeser,2 Catharina Schaecke,1 Nikolaos Panagiotopoulos,1 Kerstin Lüdtke-Buzug,2 Thorsten M Buzug,2 Jörg Barkhausen,1 Florian M Vogt1 1Clinic for Radiology and Nuclear Medicine, 2Institute of Medical Engineering, University Hospital Sch...

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Autores principales:	Haegele J, Duschka RL, Graeser M, Schaecke C, Panagiotopoulos N, Lüdtke-Buzug K, Buzug TM, Barkhausen J, Vogt FM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2adefc3d8d3441b693be0c301382c9e2
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spelling	oai:doaj.org-article:2adefc3d8d3441b693be0c301382c9e22021-12-02T03:54:13ZMagnetic particle imaging: kinetics of the intravascular signal in vivo1178-2013https://doaj.org/article/2adefc3d8d3441b693be0c301382c9e22014-09-01T00:00:00Zhttp://www.dovepress.com/magnetic-particle-imaging-kinetics-of-the-intravascular-signal-in-vivo-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Julian Haegele,1 Robert L Duschka,1 Matthias Graeser,2 Catharina Schaecke,1 Nikolaos Panagiotopoulos,1 Kerstin Lüdtke-Buzug,2 Thorsten M Buzug,2 Jörg Barkhausen,1 Florian M Vogt1 1Clinic for Radiology and Nuclear Medicine, 2Institute of Medical Engineering, University Hospital Schleswig Holstein, Lübeck, Schleswig-Holstein, Germany Background: Magnetic particle imaging (MPI) uses magnetic fields to visualize superparamagnetic iron oxide nanoparticles (SPIO). Today, Resovist® is still the reference SPIO for MPI. The objective of this study was to evaluate the in vivo blood half-life of two different types of Resovist (one from Bayer Pharma AG, and one from I’rom Pharmaceutical Co Ltd) in MPI. Methods: A Resovist concentration of 50 µmol/kg was injected into the ear artery of ten New Zealand White rabbits. Five animals received Resovist distributed by I’rom Pharmaceutical Co Ltd and five received Resovist by Bayer Pharma AG. Blood samples were drawn before and directly after injection of Resovist, at 5, 10, and 15 minutes, and then every 15 minutes until 120 minutes after the injection. The MPI signal of the blood samples was evaluated using magnetic particle spectroscopy. Results: The average decline of the blood MPI signal from the two distributions differed significantly (P=0.0056). Resovist distributed by Bayer Pharma AG showed a slower decline of the MPI signal (39.7% after 5 minutes, 20.5% after 10 minutes, and 12.1% after 15 minutes) compared with Resovist produced by I’rom Pharmaceutical Co Ltd (20.4% after 5 minutes, 7.8% after 10 minutes, no signal above noise level after 15 minutes). Conclusion: In MPI, the blood half-life of an SPIO tracer cannot be equalized to the blood half-life of its MPI signal. Resovist shows a very rapid decline of blood MPI signal and is thus not suitable as a long circulating tracer. For cardiovascular applications in MPI, it may be used as a bolus tracer. Keywords: magnetic particle imaging, superparamagnetic iron oxide nanoparticles, magnetic particle spectroscopy, blood half-life time, Resovist®Haegele JDuschka RLGraeser MSchaecke CPanagiotopoulos NLüdtke-Buzug KBuzug TMBarkhausen JVogt FMDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 4203-4209 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Haegele J Duschka RL Graeser M Schaecke C Panagiotopoulos N Lüdtke-Buzug K Buzug TM Barkhausen J Vogt FM Magnetic particle imaging: kinetics of the intravascular signal in vivo
description	Julian Haegele,1 Robert L Duschka,1 Matthias Graeser,2 Catharina Schaecke,1 Nikolaos Panagiotopoulos,1 Kerstin Lüdtke-Buzug,2 Thorsten M Buzug,2 Jörg Barkhausen,1 Florian M Vogt1 1Clinic for Radiology and Nuclear Medicine, 2Institute of Medical Engineering, University Hospital Schleswig Holstein, Lübeck, Schleswig-Holstein, Germany Background: Magnetic particle imaging (MPI) uses magnetic fields to visualize superparamagnetic iron oxide nanoparticles (SPIO). Today, Resovist® is still the reference SPIO for MPI. The objective of this study was to evaluate the in vivo blood half-life of two different types of Resovist (one from Bayer Pharma AG, and one from I’rom Pharmaceutical Co Ltd) in MPI. Methods: A Resovist concentration of 50 µmol/kg was injected into the ear artery of ten New Zealand White rabbits. Five animals received Resovist distributed by I’rom Pharmaceutical Co Ltd and five received Resovist by Bayer Pharma AG. Blood samples were drawn before and directly after injection of Resovist, at 5, 10, and 15 minutes, and then every 15 minutes until 120 minutes after the injection. The MPI signal of the blood samples was evaluated using magnetic particle spectroscopy. Results: The average decline of the blood MPI signal from the two distributions differed significantly (P=0.0056). Resovist distributed by Bayer Pharma AG showed a slower decline of the MPI signal (39.7% after 5 minutes, 20.5% after 10 minutes, and 12.1% after 15 minutes) compared with Resovist produced by I’rom Pharmaceutical Co Ltd (20.4% after 5 minutes, 7.8% after 10 minutes, no signal above noise level after 15 minutes). Conclusion: In MPI, the blood half-life of an SPIO tracer cannot be equalized to the blood half-life of its MPI signal. Resovist shows a very rapid decline of blood MPI signal and is thus not suitable as a long circulating tracer. For cardiovascular applications in MPI, it may be used as a bolus tracer. Keywords: magnetic particle imaging, superparamagnetic iron oxide nanoparticles, magnetic particle spectroscopy, blood half-life time, Resovist®
format	article
author	Haegele J Duschka RL Graeser M Schaecke C Panagiotopoulos N Lüdtke-Buzug K Buzug TM Barkhausen J Vogt FM
author_facet	Haegele J Duschka RL Graeser M Schaecke C Panagiotopoulos N Lüdtke-Buzug K Buzug TM Barkhausen J Vogt FM
author_sort	Haegele J
title	Magnetic particle imaging: kinetics of the intravascular signal in vivo
title_short	Magnetic particle imaging: kinetics of the intravascular signal in vivo
title_full	Magnetic particle imaging: kinetics of the intravascular signal in vivo
title_fullStr	Magnetic particle imaging: kinetics of the intravascular signal in vivo
title_full_unstemmed	Magnetic particle imaging: kinetics of the intravascular signal in vivo
title_sort	magnetic particle imaging: kinetics of the intravascular signal in vivo
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/2adefc3d8d3441b693be0c301382c9e2
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Magnetic particle imaging: kinetics of the intravascular signal in vivo

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