The Effects of Anthocyanin-Rich Bilberry Extract on Transintestinal Cholesterol Excretion

Hypercholesterolemia is one of the modifiable and primary risk factors for cardiovascular diseases (CVD). Emerging evidence suggests the stimulation of transintestinal cholesterol excretion (TICE), the nonbiliary cholesterol excretion, using natural products can be an effective way to reduce CVD. Bi...

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Autores principales:	Jimin Hong, Minji Kim, Bohkyung Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bilberry transintestinal cholesterol excretion LDL receptor hypocholesterolemia Caco-2 cells Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/2adfa13ad9874d9380d0a1c5c7877330
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spelling	oai:doaj.org-article:2adfa13ad9874d9380d0a1c5c78773302021-11-25T17:36:28ZThe Effects of Anthocyanin-Rich Bilberry Extract on Transintestinal Cholesterol Excretion10.3390/foods101128522304-8158https://doaj.org/article/2adfa13ad9874d9380d0a1c5c78773302021-11-01T00:00:00Zhttps://www.mdpi.com/2304-8158/10/11/2852https://doaj.org/toc/2304-8158Hypercholesterolemia is one of the modifiable and primary risk factors for cardiovascular diseases (CVD). Emerging evidence suggests the stimulation of transintestinal cholesterol excretion (TICE), the nonbiliary cholesterol excretion, using natural products can be an effective way to reduce CVD. Bilberry (<i>Vaccinium myrtillus</i> L.) has been reported to have cardioprotective effects by ameliorating oxidative stress, inflammation, and dyslipidemia. However, the role of bilberry in intestinal cholesterol metabolism is not well understood. To examine the effects of bilberry in intestinal cholesterol metabolism, we measured the genes for cholesterol flux and de novo synthesis in anthocyanin-rich bilberry extract (BE)-treated Caco-2 cells. BE significantly decreased the genes for cholesterol absorption, i.e., Niemann-Pick C1 Like 1 and ATP-binding cassette transporter A1 (ABCA1). In contrast, BE significantly upregulated ABCG8, the apical transporter for cholesterol. There was a significant induction of low-density lipoprotein receptors, with a concomitant increase in cellular uptake of cholesterol in BE-treated cells. The expression of genes for lipogenesis and sirtuins was altered by BE treatment. In the present study, BE altered the genes for cholesterol flux from basolateral to the apical membrane of enterocytes, potentially stimulating TICE. These results support the potential of BE in the prevention of hypercholesterolemia.Jimin HongMinji KimBohkyung KimMDPI AGarticlebilberrytransintestinal cholesterol excretionLDL receptorhypocholesterolemiaCaco-2 cellsChemical technologyTP1-1185ENFoods, Vol 10, Iss 2852, p 2852 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bilberry transintestinal cholesterol excretion LDL receptor hypocholesterolemia Caco-2 cells Chemical technology TP1-1185
spellingShingle	bilberry transintestinal cholesterol excretion LDL receptor hypocholesterolemia Caco-2 cells Chemical technology TP1-1185 Jimin Hong Minji Kim Bohkyung Kim The Effects of Anthocyanin-Rich Bilberry Extract on Transintestinal Cholesterol Excretion
description	Hypercholesterolemia is one of the modifiable and primary risk factors for cardiovascular diseases (CVD). Emerging evidence suggests the stimulation of transintestinal cholesterol excretion (TICE), the nonbiliary cholesterol excretion, using natural products can be an effective way to reduce CVD. Bilberry (<i>Vaccinium myrtillus</i> L.) has been reported to have cardioprotective effects by ameliorating oxidative stress, inflammation, and dyslipidemia. However, the role of bilberry in intestinal cholesterol metabolism is not well understood. To examine the effects of bilberry in intestinal cholesterol metabolism, we measured the genes for cholesterol flux and de novo synthesis in anthocyanin-rich bilberry extract (BE)-treated Caco-2 cells. BE significantly decreased the genes for cholesterol absorption, i.e., Niemann-Pick C1 Like 1 and ATP-binding cassette transporter A1 (ABCA1). In contrast, BE significantly upregulated ABCG8, the apical transporter for cholesterol. There was a significant induction of low-density lipoprotein receptors, with a concomitant increase in cellular uptake of cholesterol in BE-treated cells. The expression of genes for lipogenesis and sirtuins was altered by BE treatment. In the present study, BE altered the genes for cholesterol flux from basolateral to the apical membrane of enterocytes, potentially stimulating TICE. These results support the potential of BE in the prevention of hypercholesterolemia.
format	article
author	Jimin Hong Minji Kim Bohkyung Kim
author_facet	Jimin Hong Minji Kim Bohkyung Kim
author_sort	Jimin Hong
title	The Effects of Anthocyanin-Rich Bilberry Extract on Transintestinal Cholesterol Excretion
title_short	The Effects of Anthocyanin-Rich Bilberry Extract on Transintestinal Cholesterol Excretion
title_full	The Effects of Anthocyanin-Rich Bilberry Extract on Transintestinal Cholesterol Excretion
title_fullStr	The Effects of Anthocyanin-Rich Bilberry Extract on Transintestinal Cholesterol Excretion
title_full_unstemmed	The Effects of Anthocyanin-Rich Bilberry Extract on Transintestinal Cholesterol Excretion
title_sort	effects of anthocyanin-rich bilberry extract on transintestinal cholesterol excretion
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2adfa13ad9874d9380d0a1c5c7877330
work_keys_str_mv	AT jiminhong theeffectsofanthocyaninrichbilberryextractontransintestinalcholesterolexcretion AT minjikim theeffectsofanthocyaninrichbilberryextractontransintestinalcholesterolexcretion AT bohkyungkim theeffectsofanthocyaninrichbilberryextractontransintestinalcholesterolexcretion AT jiminhong effectsofanthocyaninrichbilberryextractontransintestinalcholesterolexcretion AT minjikim effectsofanthocyaninrichbilberryextractontransintestinalcholesterolexcretion AT bohkyungkim effectsofanthocyaninrichbilberryextractontransintestinalcholesterolexcretion
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The Effects of Anthocyanin-Rich Bilberry Extract on Transintestinal Cholesterol Excretion

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