Metabolic Profiling of Type 2 Diabetes Patients after Bariatric Surgery by Raman Spectroscopy

Background: Bariatric surgery (BS) is an important procedure used for the treatment of morbid obesity and has been proven to improve, or even cure, type 2 diabetes mellitus (T2DM). However, of the patients with T2DM who initially go into remission, a proportion experience a relapse during the follow...

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Autores principales:	Arianna Bonizzi, Marta Sevieri, Leopoldo Sitia, Andrea Rizzi, Lorenzo Conti, Fabio Corsi, Carlo Morasso, Serena Mazzucchelli
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	type 2 diabetes mellitus obesity bariatric surgery remission Raman spectroscopy Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/2ae3cd64bfdc4f9f81bddab45e228d05
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spelling	oai:doaj.org-article:2ae3cd64bfdc4f9f81bddab45e228d052021-11-25T16:35:57ZMetabolic Profiling of Type 2 Diabetes Patients after Bariatric Surgery by Raman Spectroscopy10.3390/app1122107102076-3417https://doaj.org/article/2ae3cd64bfdc4f9f81bddab45e228d052021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/10710https://doaj.org/toc/2076-3417Background: Bariatric surgery (BS) is an important procedure used for the treatment of morbid obesity and has been proven to improve, or even cure, type 2 diabetes mellitus (T2DM). However, of the patients with T2DM who initially go into remission, a proportion experience a relapse during the follow-up. In this context, Raman spectroscopy (RS) could be a promising technique for monitoring the metabolic profile of patients after surgical treatment with the aim of improving their postsurgical management. Methods: Fourteen obese patients with T2DM were recruited. Clinical parameters, adipokines, ghrelin, Fibroblast growth factor 19 (FGF-19) values, and Raman spectra were collected and analyzed before and after surgery. RS results were compared with profiles obtained from 23 healthy subjects (HC), to observe whether the metabolic fingerprint of bariatric patients normalized during the surgical follow-up. Results: The reduction in anthropometric measures and improved glycemic control and lipid profile after surgical treatment highlighted the benefits of BS. Consequently, adipokines, ghrelin and FGF-19 concentration returned to normal values after surgery. However, RS data highlighted an altered metabolic profile even after BS. Conclusion: RS suggests that BS does not fully restore the metabolic profile of patients in the immediate follow-up after the surgery.Arianna BonizziMarta SevieriLeopoldo SitiaAndrea RizziLorenzo ContiFabio CorsiCarlo MorassoSerena MazzucchelliMDPI AGarticletype 2 diabetes mellitusobesitybariatric surgeryremissionRaman spectroscopyTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10710, p 10710 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 2 diabetes mellitus obesity bariatric surgery remission Raman spectroscopy Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	type 2 diabetes mellitus obesity bariatric surgery remission Raman spectroscopy Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Arianna Bonizzi Marta Sevieri Leopoldo Sitia Andrea Rizzi Lorenzo Conti Fabio Corsi Carlo Morasso Serena Mazzucchelli Metabolic Profiling of Type 2 Diabetes Patients after Bariatric Surgery by Raman Spectroscopy
description	Background: Bariatric surgery (BS) is an important procedure used for the treatment of morbid obesity and has been proven to improve, or even cure, type 2 diabetes mellitus (T2DM). However, of the patients with T2DM who initially go into remission, a proportion experience a relapse during the follow-up. In this context, Raman spectroscopy (RS) could be a promising technique for monitoring the metabolic profile of patients after surgical treatment with the aim of improving their postsurgical management. Methods: Fourteen obese patients with T2DM were recruited. Clinical parameters, adipokines, ghrelin, Fibroblast growth factor 19 (FGF-19) values, and Raman spectra were collected and analyzed before and after surgery. RS results were compared with profiles obtained from 23 healthy subjects (HC), to observe whether the metabolic fingerprint of bariatric patients normalized during the surgical follow-up. Results: The reduction in anthropometric measures and improved glycemic control and lipid profile after surgical treatment highlighted the benefits of BS. Consequently, adipokines, ghrelin and FGF-19 concentration returned to normal values after surgery. However, RS data highlighted an altered metabolic profile even after BS. Conclusion: RS suggests that BS does not fully restore the metabolic profile of patients in the immediate follow-up after the surgery.
format	article
author	Arianna Bonizzi Marta Sevieri Leopoldo Sitia Andrea Rizzi Lorenzo Conti Fabio Corsi Carlo Morasso Serena Mazzucchelli
author_facet	Arianna Bonizzi Marta Sevieri Leopoldo Sitia Andrea Rizzi Lorenzo Conti Fabio Corsi Carlo Morasso Serena Mazzucchelli
author_sort	Arianna Bonizzi
title	Metabolic Profiling of Type 2 Diabetes Patients after Bariatric Surgery by Raman Spectroscopy
title_short	Metabolic Profiling of Type 2 Diabetes Patients after Bariatric Surgery by Raman Spectroscopy
title_full	Metabolic Profiling of Type 2 Diabetes Patients after Bariatric Surgery by Raman Spectroscopy
title_fullStr	Metabolic Profiling of Type 2 Diabetes Patients after Bariatric Surgery by Raman Spectroscopy
title_full_unstemmed	Metabolic Profiling of Type 2 Diabetes Patients after Bariatric Surgery by Raman Spectroscopy
title_sort	metabolic profiling of type 2 diabetes patients after bariatric surgery by raman spectroscopy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2ae3cd64bfdc4f9f81bddab45e228d05
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Metabolic Profiling of Type 2 Diabetes Patients after Bariatric Surgery by Raman Spectroscopy

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