Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1

PERK stress signaling is an important driver of cancer invasion and metastasis, but chemical inhibitors of PERK cause side effects. Here, the authors find that CREB3L1 is required for PERK's pro-metastatic function in breast cancer, and its inhibition suppresses cancer invasion and metastasis.

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Autores principales:	Yu-Xiong Feng, Dexter X. Jin, Ethan S. Sokol, Ferenc Reinhardt, Daniel H. Miller, Piyush B. Gupta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2ae8ee04689248f48c5cb9be74fcd777
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spelling	oai:doaj.org-article:2ae8ee04689248f48c5cb9be74fcd7772021-12-02T14:42:41ZCancer-specific PERK signaling drives invasion and metastasis through CREB3L110.1038/s41467-017-01052-y2041-1723https://doaj.org/article/2ae8ee04689248f48c5cb9be74fcd7772017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01052-yhttps://doaj.org/toc/2041-1723PERK stress signaling is an important driver of cancer invasion and metastasis, but chemical inhibitors of PERK cause side effects. Here, the authors find that CREB3L1 is required for PERK's pro-metastatic function in breast cancer, and its inhibition suppresses cancer invasion and metastasis.Yu-Xiong FengDexter X. JinEthan S. SokolFerenc ReinhardtDaniel H. MillerPiyush B. GuptaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu-Xiong Feng Dexter X. Jin Ethan S. Sokol Ferenc Reinhardt Daniel H. Miller Piyush B. Gupta Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1
description	PERK stress signaling is an important driver of cancer invasion and metastasis, but chemical inhibitors of PERK cause side effects. Here, the authors find that CREB3L1 is required for PERK's pro-metastatic function in breast cancer, and its inhibition suppresses cancer invasion and metastasis.
format	article
author	Yu-Xiong Feng Dexter X. Jin Ethan S. Sokol Ferenc Reinhardt Daniel H. Miller Piyush B. Gupta
author_facet	Yu-Xiong Feng Dexter X. Jin Ethan S. Sokol Ferenc Reinhardt Daniel H. Miller Piyush B. Gupta
author_sort	Yu-Xiong Feng
title	Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1
title_short	Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1
title_full	Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1
title_fullStr	Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1
title_full_unstemmed	Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1
title_sort	cancer-specific perk signaling drives invasion and metastasis through creb3l1
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2ae8ee04689248f48c5cb9be74fcd777
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Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1

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