Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1

Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1

PERK stress signaling is an important driver of cancer invasion and metastasis, but chemical inhibitors of PERK cause side effects. Here, the authors find that CREB3L1 is required for PERK's pro-metastatic function in breast cancer, and its inhibition suppresses cancer invasion and metastasis.

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Autores principales: Yu-Xiong Feng, Dexter X. Jin, Ethan S. Sokol, Ferenc Reinhardt, Daniel H. Miller, Piyush B. Gupta
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/2ae8ee04689248f48c5cb9be74fcd777
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