Copper nanoparticles supported on polyethylene glycol-modified magnetic Fe3O4 nanoparticles: Its anti-human gastric cancer investigation

In that work, we have described the synthesis of novel Cu NPs decorated polyethylene glycol (PEG2000) coated magnetic nanoparticles (Fe3O4/PEG2000/Cu NPs) in an eco-friendly pathway applying Green Tea extract as reducing/stabilizing agent. The morphological and physicochemical features of the prepar...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Tian Tang, Zhisheng Liu, Kai Wang, Tingting Wang, Ye Wang, Yunjie Ge
Formato: article
Lenguaje:EN
Publicado: Elsevier 2022
Materias:
PEG
Acceso en línea:https://doaj.org/article/2aece31e92834668b5a87fa4878c8152
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:In that work, we have described the synthesis of novel Cu NPs decorated polyethylene glycol (PEG2000) coated magnetic nanoparticles (Fe3O4/PEG2000/Cu NPs) in an eco-friendly pathway applying Green Tea extract as reducing/stabilizing agent. The morphological and physicochemical features of the prepared nanocomposite were determined using several advanced techniques like ICP-OES, FE-SEM, EDX, atomic mapping, TEM, VSM, and XRD studies. In the antioxidant test, the IC50 of Fe3O4/PEG2000/Cu nanocomposite and BHT against DPPH free radicals were 198 and 85 µg/mL, respectively. In the cellular and molecular part of the recent study, the treated cells with Fe3O4/PEG2000/Cu nanocomposite were assessed by MTT assay for 48 h about the cytotoxicity and anti-human gastric cancer properties on normal (HUVEC) and gastric cancer cell lines i.e. NCI-N87 and MKN45. The IC50 of Fe3O4/PEG2000/Cu nanocomposite were 316 and 131 µg/mL against NCI-N87 and MKN45 cell lines, respectively. The viability of malignant gastric cell line reduced dose-dependently in the presence of Fe3O4/PEG2000/Cu nanocomposite. It seems that the anti-human gastric cancer effect of recent nanoparticles is due to their antioxidant effects.