Copper nanoparticles supported on polyethylene glycol-modified magnetic Fe3O4 nanoparticles: Its anti-human gastric cancer investigation

In that work, we have described the synthesis of novel Cu NPs decorated polyethylene glycol (PEG2000) coated magnetic nanoparticles (Fe3O4/PEG2000/Cu NPs) in an eco-friendly pathway applying Green Tea extract as reducing/stabilizing agent. The morphological and physicochemical features of the prepar...

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Autores principales:	Tian Tang, Zhisheng Liu, Kai Wang, Tingting Wang, Ye Wang, Yunjie Ge
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	PEG Cu nanoparticles Nonmagnetic Human gastric cancer Antioxidant Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/2aece31e92834668b5a87fa4878c8152
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spelling	oai:doaj.org-article:2aece31e92834668b5a87fa4878c81522021-11-18T04:46:23ZCopper nanoparticles supported on polyethylene glycol-modified magnetic Fe3O4 nanoparticles: Its anti-human gastric cancer investigation1878-535210.1016/j.arabjc.2021.103523https://doaj.org/article/2aece31e92834668b5a87fa4878c81522022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1878535221005384https://doaj.org/toc/1878-5352In that work, we have described the synthesis of novel Cu NPs decorated polyethylene glycol (PEG2000) coated magnetic nanoparticles (Fe3O4/PEG2000/Cu NPs) in an eco-friendly pathway applying Green Tea extract as reducing/stabilizing agent. The morphological and physicochemical features of the prepared nanocomposite were determined using several advanced techniques like ICP-OES, FE-SEM, EDX, atomic mapping, TEM, VSM, and XRD studies. In the antioxidant test, the IC50 of Fe3O4/PEG2000/Cu nanocomposite and BHT against DPPH free radicals were 198 and 85 µg/mL, respectively. In the cellular and molecular part of the recent study, the treated cells with Fe3O4/PEG2000/Cu nanocomposite were assessed by MTT assay for 48 h about the cytotoxicity and anti-human gastric cancer properties on normal (HUVEC) and gastric cancer cell lines i.e. NCI-N87 and MKN45. The IC50 of Fe3O4/PEG2000/Cu nanocomposite were 316 and 131 µg/mL against NCI-N87 and MKN45 cell lines, respectively. The viability of malignant gastric cell line reduced dose-dependently in the presence of Fe3O4/PEG2000/Cu nanocomposite. It seems that the anti-human gastric cancer effect of recent nanoparticles is due to their antioxidant effects.Tian TangZhisheng LiuKai WangTingting WangYe WangYunjie GeElsevierarticlePEGCu nanoparticlesNonmagneticHuman gastric cancerAntioxidantChemistryQD1-999ENArabian Journal of Chemistry, Vol 15, Iss 1, Pp 103523- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	PEG Cu nanoparticles Nonmagnetic Human gastric cancer Antioxidant Chemistry QD1-999
spellingShingle	PEG Cu nanoparticles Nonmagnetic Human gastric cancer Antioxidant Chemistry QD1-999 Tian Tang Zhisheng Liu Kai Wang Tingting Wang Ye Wang Yunjie Ge Copper nanoparticles supported on polyethylene glycol-modified magnetic Fe3O4 nanoparticles: Its anti-human gastric cancer investigation
description	In that work, we have described the synthesis of novel Cu NPs decorated polyethylene glycol (PEG2000) coated magnetic nanoparticles (Fe3O4/PEG2000/Cu NPs) in an eco-friendly pathway applying Green Tea extract as reducing/stabilizing agent. The morphological and physicochemical features of the prepared nanocomposite were determined using several advanced techniques like ICP-OES, FE-SEM, EDX, atomic mapping, TEM, VSM, and XRD studies. In the antioxidant test, the IC50 of Fe3O4/PEG2000/Cu nanocomposite and BHT against DPPH free radicals were 198 and 85 µg/mL, respectively. In the cellular and molecular part of the recent study, the treated cells with Fe3O4/PEG2000/Cu nanocomposite were assessed by MTT assay for 48 h about the cytotoxicity and anti-human gastric cancer properties on normal (HUVEC) and gastric cancer cell lines i.e. NCI-N87 and MKN45. The IC50 of Fe3O4/PEG2000/Cu nanocomposite were 316 and 131 µg/mL against NCI-N87 and MKN45 cell lines, respectively. The viability of malignant gastric cell line reduced dose-dependently in the presence of Fe3O4/PEG2000/Cu nanocomposite. It seems that the anti-human gastric cancer effect of recent nanoparticles is due to their antioxidant effects.
format	article
author	Tian Tang Zhisheng Liu Kai Wang Tingting Wang Ye Wang Yunjie Ge
author_facet	Tian Tang Zhisheng Liu Kai Wang Tingting Wang Ye Wang Yunjie Ge
author_sort	Tian Tang
title	Copper nanoparticles supported on polyethylene glycol-modified magnetic Fe3O4 nanoparticles: Its anti-human gastric cancer investigation
title_short	Copper nanoparticles supported on polyethylene glycol-modified magnetic Fe3O4 nanoparticles: Its anti-human gastric cancer investigation
title_full	Copper nanoparticles supported on polyethylene glycol-modified magnetic Fe3O4 nanoparticles: Its anti-human gastric cancer investigation
title_fullStr	Copper nanoparticles supported on polyethylene glycol-modified magnetic Fe3O4 nanoparticles: Its anti-human gastric cancer investigation
title_full_unstemmed	Copper nanoparticles supported on polyethylene glycol-modified magnetic Fe3O4 nanoparticles: Its anti-human gastric cancer investigation
title_sort	copper nanoparticles supported on polyethylene glycol-modified magnetic fe3o4 nanoparticles: its anti-human gastric cancer investigation
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/2aece31e92834668b5a87fa4878c8152
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Copper nanoparticles supported on polyethylene glycol-modified magnetic Fe3O4 nanoparticles: Its anti-human gastric cancer investigation

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