MKK6 controls T3-mediated browning of white adipose tissue

Brown and beige adipose tissues dissipate heat via uncoupling protein 1 (UCP1). Here the authors show that the stress activated kinase MKK6 acts as a repressor of UCP1 expression, suggesting that its inhibition promotes adipose tissue browning and increases organismal energy expenditure.

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Autores principales:	Nuria Matesanz, Edgar Bernardo, Rebeca Acín-Pérez, Elisa Manieri, Sonia Pérez-Sieira, Lourdes Hernández-Cosido, Valle Montalvo-Romeral, Alfonso Mora, Elena Rodríguez, Luis Leiva-Vega, Ana Victoria Lechuga-Vieco, Jesús Ruiz-Cabello, Jorge L. Torres, Maria Crespo-Ruiz, Francisco Centeno, Clara V. Álvarez, Miguel Marcos, Jose Antonio Enríquez, Ruben Nogueiras, Guadalupe Sabio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2aee8a2191dc416bb7efc458ac892fc6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:2aee8a2191dc416bb7efc458ac892fc62021-12-02T14:40:35ZMKK6 controls T3-mediated browning of white adipose tissue10.1038/s41467-017-00948-z2041-1723https://doaj.org/article/2aee8a2191dc416bb7efc458ac892fc62017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00948-zhttps://doaj.org/toc/2041-1723Brown and beige adipose tissues dissipate heat via uncoupling protein 1 (UCP1). Here the authors show that the stress activated kinase MKK6 acts as a repressor of UCP1 expression, suggesting that its inhibition promotes adipose tissue browning and increases organismal energy expenditure.Nuria MatesanzEdgar BernardoRebeca Acín-PérezElisa ManieriSonia Pérez-SieiraLourdes Hernández-CosidoValle Montalvo-RomeralAlfonso MoraElena RodríguezLuis Leiva-VegaAna Victoria Lechuga-ViecoJesús Ruiz-CabelloJorge L. TorresMaria Crespo-RuizFrancisco CentenoClara V. ÁlvarezMiguel MarcosJose Antonio EnríquezRuben NogueirasGuadalupe SabioNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nuria Matesanz Edgar Bernardo Rebeca Acín-Pérez Elisa Manieri Sonia Pérez-Sieira Lourdes Hernández-Cosido Valle Montalvo-Romeral Alfonso Mora Elena Rodríguez Luis Leiva-Vega Ana Victoria Lechuga-Vieco Jesús Ruiz-Cabello Jorge L. Torres Maria Crespo-Ruiz Francisco Centeno Clara V. Álvarez Miguel Marcos Jose Antonio Enríquez Ruben Nogueiras Guadalupe Sabio MKK6 controls T3-mediated browning of white adipose tissue
description	Brown and beige adipose tissues dissipate heat via uncoupling protein 1 (UCP1). Here the authors show that the stress activated kinase MKK6 acts as a repressor of UCP1 expression, suggesting that its inhibition promotes adipose tissue browning and increases organismal energy expenditure.
format	article
author	Nuria Matesanz Edgar Bernardo Rebeca Acín-Pérez Elisa Manieri Sonia Pérez-Sieira Lourdes Hernández-Cosido Valle Montalvo-Romeral Alfonso Mora Elena Rodríguez Luis Leiva-Vega Ana Victoria Lechuga-Vieco Jesús Ruiz-Cabello Jorge L. Torres Maria Crespo-Ruiz Francisco Centeno Clara V. Álvarez Miguel Marcos Jose Antonio Enríquez Ruben Nogueiras Guadalupe Sabio
author_facet	Nuria Matesanz Edgar Bernardo Rebeca Acín-Pérez Elisa Manieri Sonia Pérez-Sieira Lourdes Hernández-Cosido Valle Montalvo-Romeral Alfonso Mora Elena Rodríguez Luis Leiva-Vega Ana Victoria Lechuga-Vieco Jesús Ruiz-Cabello Jorge L. Torres Maria Crespo-Ruiz Francisco Centeno Clara V. Álvarez Miguel Marcos Jose Antonio Enríquez Ruben Nogueiras Guadalupe Sabio
author_sort	Nuria Matesanz
title	MKK6 controls T3-mediated browning of white adipose tissue
title_short	MKK6 controls T3-mediated browning of white adipose tissue
title_full	MKK6 controls T3-mediated browning of white adipose tissue
title_fullStr	MKK6 controls T3-mediated browning of white adipose tissue
title_full_unstemmed	MKK6 controls T3-mediated browning of white adipose tissue
title_sort	mkk6 controls t3-mediated browning of white adipose tissue
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2aee8a2191dc416bb7efc458ac892fc6
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MKK6 controls T3-mediated browning of white adipose tissue

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