Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors

The immunosuppressive tumour microenvironment impairs immunotherapy in poorly immunogenic cancer. Here, the authors load an alginate gel with GM-CSF, CpG oligonucleotides and doxorubicin-iRGD to promote immunogenic death of tumour cells and improve immunotherapy efficacy in triple negative breast ca...

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Autores principales:	Hua Wang, Alexander J. Najibi, Miguel C. Sobral, Bo Ri Seo, Jun Yong Lee, David Wu, Aileen Weiwei Li, Catia S. Verbeke, David J. Mooney
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2af10e759cc3482da0ca26d55a1844d7
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spelling	oai:doaj.org-article:2af10e759cc3482da0ca26d55a1844d72021-12-02T16:49:28ZBiomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors10.1038/s41467-020-19540-z2041-1723https://doaj.org/article/2af10e759cc3482da0ca26d55a1844d72020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19540-zhttps://doaj.org/toc/2041-1723The immunosuppressive tumour microenvironment impairs immunotherapy in poorly immunogenic cancer. Here, the authors load an alginate gel with GM-CSF, CpG oligonucleotides and doxorubicin-iRGD to promote immunogenic death of tumour cells and improve immunotherapy efficacy in triple negative breast cancer models.Hua WangAlexander J. NajibiMiguel C. SobralBo Ri SeoJun Yong LeeDavid WuAileen Weiwei LiCatia S. VerbekeDavid J. MooneyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hua Wang Alexander J. Najibi Miguel C. Sobral Bo Ri Seo Jun Yong Lee David Wu Aileen Weiwei Li Catia S. Verbeke David J. Mooney Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors
description	The immunosuppressive tumour microenvironment impairs immunotherapy in poorly immunogenic cancer. Here, the authors load an alginate gel with GM-CSF, CpG oligonucleotides and doxorubicin-iRGD to promote immunogenic death of tumour cells and improve immunotherapy efficacy in triple negative breast cancer models.
format	article
author	Hua Wang Alexander J. Najibi Miguel C. Sobral Bo Ri Seo Jun Yong Lee David Wu Aileen Weiwei Li Catia S. Verbeke David J. Mooney
author_facet	Hua Wang Alexander J. Najibi Miguel C. Sobral Bo Ri Seo Jun Yong Lee David Wu Aileen Weiwei Li Catia S. Verbeke David J. Mooney
author_sort	Hua Wang
title	Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors
title_short	Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors
title_full	Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors
title_fullStr	Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors
title_full_unstemmed	Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors
title_sort	biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2af10e759cc3482da0ca26d55a1844d7
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Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors

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