Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors

The immunosuppressive tumour microenvironment impairs immunotherapy in poorly immunogenic cancer. Here, the authors load an alginate gel with GM-CSF, CpG oligonucleotides and doxorubicin-iRGD to promote immunogenic death of tumour cells and improve immunotherapy efficacy in triple negative breast ca...

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Auteurs principaux: Hua Wang, Alexander J. Najibi, Miguel C. Sobral, Bo Ri Seo, Jun Yong Lee, David Wu, Aileen Weiwei Li, Catia S. Verbeke, David J. Mooney
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/2af10e759cc3482da0ca26d55a1844d7
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