Oral vitamin C restores endothelial function during acute inflammation in young and older adults

Abstract Oxidative stress has been linked to reductions in vascular function during acute inflammation in young adults; however, the effect of acute inflammation on vascular function with aging is inconclusive. The aim of this study was to determine if oral antioxidant administration eliminates vasc...

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Autores principales:	Elizabeth C. Lefferts, Brooks A. Hibner, Wesley K. Lefferts, Natalia S. Lima, Tracy Baynard, Jacob M. Haus, Abbi D. Lane‐Cordova, Shane A. Phillips, Bo Fernhall
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	antioxidant ascorbate flow‐mediated dilation pulse wave velocity Physiology QP1-981
Acceso en línea:	https://doaj.org/article/2af15151ab3f4c2f963b422a773701a1
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spelling	oai:doaj.org-article:2af15151ab3f4c2f963b422a773701a12021-11-15T09:54:41ZOral vitamin C restores endothelial function during acute inflammation in young and older adults2051-817X10.14814/phy2.15104https://doaj.org/article/2af15151ab3f4c2f963b422a773701a12021-11-01T00:00:00Zhttps://doi.org/10.14814/phy2.15104https://doaj.org/toc/2051-817XAbstract Oxidative stress has been linked to reductions in vascular function during acute inflammation in young adults; however, the effect of acute inflammation on vascular function with aging is inconclusive. The aim of this study was to determine if oral antioxidant administration eliminates vascular dysfunction during acute inflammation in young and older adults. Brachial flow‐mediated dilation (FMD) and carotid‐femoral pulse wave velocity (PWV) were measured in nine young (3 male, 24 ± 4 yrs, 26.2 ± 4.9 kg/m2) and 16 older (13 male, 64 ± 5 yrs, 25.8 ± 3.2 kg/m2) adults before and 2‐h after oral consumption of 2 g of vitamin C. The vitamin C protocol was completed at rest and 24 h after acute inflammation was induced via the typhoid vaccine. Venous blood samples were taken to measure markers of inflammation and vitamin C. Both interleukin‐6 (Δ+0.7 ± 1.8 pg/ml) and C‐reactive protein (Δ+1.9 ± 3.1 mg/L) were increased at 24 h following the vaccine (p < 0.01). There was no change in FMD or PWV following vitamin C administration at rest (p > 0.05). FMD was lower in all groups during acute inflammation (Δ‐1.4 ± 1.9%, p < 0.01), with no changes in PWV (Δ‐0.0 ± 0.9 m/s, p > 0.05). Vitamin C restored FMD back to initial values in young and older adults during acute inflammation (Δ+1.0 ± 1.8%, p < 0.01) with no change in inflammatory markers or PWV (p > 0.05). In conclusion, oral vitamin C restored endothelial function during acute inflammation in young and older adults, with no effect on aortic stiffness. The effect of vitamin C on endothelial function did not appear to be due to reductions in inflammatory markers. The exact mechanisms should be further investigated.Elizabeth C. LeffertsBrooks A. HibnerWesley K. LeffertsNatalia S. LimaTracy BaynardJacob M. HausAbbi D. Lane‐CordovaShane A. PhillipsBo FernhallWileyarticleantioxidantascorbateflow‐mediated dilationpulse wave velocityPhysiologyQP1-981ENPhysiological Reports, Vol 9, Iss 21, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antioxidant ascorbate flow‐mediated dilation pulse wave velocity Physiology QP1-981
spellingShingle	antioxidant ascorbate flow‐mediated dilation pulse wave velocity Physiology QP1-981 Elizabeth C. Lefferts Brooks A. Hibner Wesley K. Lefferts Natalia S. Lima Tracy Baynard Jacob M. Haus Abbi D. Lane‐Cordova Shane A. Phillips Bo Fernhall Oral vitamin C restores endothelial function during acute inflammation in young and older adults
description	Abstract Oxidative stress has been linked to reductions in vascular function during acute inflammation in young adults; however, the effect of acute inflammation on vascular function with aging is inconclusive. The aim of this study was to determine if oral antioxidant administration eliminates vascular dysfunction during acute inflammation in young and older adults. Brachial flow‐mediated dilation (FMD) and carotid‐femoral pulse wave velocity (PWV) were measured in nine young (3 male, 24 ± 4 yrs, 26.2 ± 4.9 kg/m2) and 16 older (13 male, 64 ± 5 yrs, 25.8 ± 3.2 kg/m2) adults before and 2‐h after oral consumption of 2 g of vitamin C. The vitamin C protocol was completed at rest and 24 h after acute inflammation was induced via the typhoid vaccine. Venous blood samples were taken to measure markers of inflammation and vitamin C. Both interleukin‐6 (Δ+0.7 ± 1.8 pg/ml) and C‐reactive protein (Δ+1.9 ± 3.1 mg/L) were increased at 24 h following the vaccine (p < 0.01). There was no change in FMD or PWV following vitamin C administration at rest (p > 0.05). FMD was lower in all groups during acute inflammation (Δ‐1.4 ± 1.9%, p < 0.01), with no changes in PWV (Δ‐0.0 ± 0.9 m/s, p > 0.05). Vitamin C restored FMD back to initial values in young and older adults during acute inflammation (Δ+1.0 ± 1.8%, p < 0.01) with no change in inflammatory markers or PWV (p > 0.05). In conclusion, oral vitamin C restored endothelial function during acute inflammation in young and older adults, with no effect on aortic stiffness. The effect of vitamin C on endothelial function did not appear to be due to reductions in inflammatory markers. The exact mechanisms should be further investigated.
format	article
author	Elizabeth C. Lefferts Brooks A. Hibner Wesley K. Lefferts Natalia S. Lima Tracy Baynard Jacob M. Haus Abbi D. Lane‐Cordova Shane A. Phillips Bo Fernhall
author_facet	Elizabeth C. Lefferts Brooks A. Hibner Wesley K. Lefferts Natalia S. Lima Tracy Baynard Jacob M. Haus Abbi D. Lane‐Cordova Shane A. Phillips Bo Fernhall
author_sort	Elizabeth C. Lefferts
title	Oral vitamin C restores endothelial function during acute inflammation in young and older adults
title_short	Oral vitamin C restores endothelial function during acute inflammation in young and older adults
title_full	Oral vitamin C restores endothelial function during acute inflammation in young and older adults
title_fullStr	Oral vitamin C restores endothelial function during acute inflammation in young and older adults
title_full_unstemmed	Oral vitamin C restores endothelial function during acute inflammation in young and older adults
title_sort	oral vitamin c restores endothelial function during acute inflammation in young and older adults
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/2af15151ab3f4c2f963b422a773701a1
work_keys_str_mv	AT elizabethclefferts oralvitamincrestoresendothelialfunctionduringacuteinflammationinyoungandolderadults AT brooksahibner oralvitamincrestoresendothelialfunctionduringacuteinflammationinyoungandolderadults AT wesleyklefferts oralvitamincrestoresendothelialfunctionduringacuteinflammationinyoungandolderadults AT nataliaslima oralvitamincrestoresendothelialfunctionduringacuteinflammationinyoungandolderadults AT tracybaynard oralvitamincrestoresendothelialfunctionduringacuteinflammationinyoungandolderadults AT jacobmhaus oralvitamincrestoresendothelialfunctionduringacuteinflammationinyoungandolderadults AT abbidlanecordova oralvitamincrestoresendothelialfunctionduringacuteinflammationinyoungandolderadults AT shaneaphillips oralvitamincrestoresendothelialfunctionduringacuteinflammationinyoungandolderadults AT bofernhall oralvitamincrestoresendothelialfunctionduringacuteinflammationinyoungandolderadults
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Oral vitamin C restores endothelial function during acute inflammation in young and older adults

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