Role of the Cell Cycle in Collective Cell Dynamics

Cells coexist together in colonies or as tissues. Their behavior is controlled by an interplay between intercellular forces and biochemical regulation. We develop a simple model of the cell cycle, the fundamental regulatory network controlling growth and division, and couple this to the physical for...

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Autores principales:	Jintao Li, Simon K. Schnyder, Matthew S. Turner, Ryoichi Yamamoto
Formato:	article
Lenguaje:	EN
Publicado:	American Physical Society 2021
Materias:	Physics QC1-999
Acceso en línea:	https://doaj.org/article/2af15fb7fa8446799b9a9215f9472dc1
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spelling	oai:doaj.org-article:2af15fb7fa8446799b9a9215f9472dc12021-12-02T14:53:02ZRole of the Cell Cycle in Collective Cell Dynamics10.1103/PhysRevX.11.0310252160-3308https://doaj.org/article/2af15fb7fa8446799b9a9215f9472dc12021-07-01T00:00:00Zhttp://doi.org/10.1103/PhysRevX.11.031025http://doi.org/10.1103/PhysRevX.11.031025https://doaj.org/toc/2160-3308Cells coexist together in colonies or as tissues. Their behavior is controlled by an interplay between intercellular forces and biochemical regulation. We develop a simple model of the cell cycle, the fundamental regulatory network controlling growth and division, and couple this to the physical forces arising within the cell collective. We analyze this model using both particle-based computer simulations and a continuum theory. We focus on 2D colonies confined in a channel. These develop moving growth fronts of dividing cells with quiescent cells in the interior. The profile and speed of these fronts are nontrivially related to the substrate friction and the cell-cycle parameters, providing a possible approach to measure such parameters in experiments.Jintao LiSimon K. SchnyderMatthew S. TurnerRyoichi YamamotoAmerican Physical SocietyarticlePhysicsQC1-999ENPhysical Review X, Vol 11, Iss 3, p 031025 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Physics QC1-999
spellingShingle	Physics QC1-999 Jintao Li Simon K. Schnyder Matthew S. Turner Ryoichi Yamamoto Role of the Cell Cycle in Collective Cell Dynamics
description	Cells coexist together in colonies or as tissues. Their behavior is controlled by an interplay between intercellular forces and biochemical regulation. We develop a simple model of the cell cycle, the fundamental regulatory network controlling growth and division, and couple this to the physical forces arising within the cell collective. We analyze this model using both particle-based computer simulations and a continuum theory. We focus on 2D colonies confined in a channel. These develop moving growth fronts of dividing cells with quiescent cells in the interior. The profile and speed of these fronts are nontrivially related to the substrate friction and the cell-cycle parameters, providing a possible approach to measure such parameters in experiments.
format	article
author	Jintao Li Simon K. Schnyder Matthew S. Turner Ryoichi Yamamoto
author_facet	Jintao Li Simon K. Schnyder Matthew S. Turner Ryoichi Yamamoto
author_sort	Jintao Li
title	Role of the Cell Cycle in Collective Cell Dynamics
title_short	Role of the Cell Cycle in Collective Cell Dynamics
title_full	Role of the Cell Cycle in Collective Cell Dynamics
title_fullStr	Role of the Cell Cycle in Collective Cell Dynamics
title_full_unstemmed	Role of the Cell Cycle in Collective Cell Dynamics
title_sort	role of the cell cycle in collective cell dynamics
publisher	American Physical Society
publishDate	2021
url	https://doaj.org/article/2af15fb7fa8446799b9a9215f9472dc1
work_keys_str_mv	AT jintaoli roleofthecellcycleincollectivecelldynamics AT simonkschnyder roleofthecellcycleincollectivecelldynamics AT matthewsturner roleofthecellcycleincollectivecelldynamics AT ryoichiyamamoto roleofthecellcycleincollectivecelldynamics
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Role of the Cell Cycle in Collective Cell Dynamics

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