Retinoblastoma from human stem cell-derived retinal organoids

Retinoblastoma from human stem cell-derived retinal organoids

Retinoblastoma is a heritable pediatric cancer driven by mutations in RB1. Here, the authors demonstrate the first patient derived model of retinoblastoma using iPSCs from patients with germline mutations in RB1.

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Autores principales: Jackie L. Norrie, Anjana Nityanandam, Karen Lai, Xiang Chen, Matthew Wilson, Elizabeth Stewart, Lyra Griffiths, Hongjian Jin, Gang Wu, Brent Orr, Quynh Tran, Sariah Allen, Colleen Reilly, Xin Zhou, Jiakun Zhang, Kyle Newman, Dianna Johnson, Rachel Brennan, Michael A. Dyer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/2af30f8f756c41dbaef2dbee86175079
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spelling oai:doaj.org-article:2af30f8f756c41dbaef2dbee861750792021-12-02T16:31:49ZRetinoblastoma from human stem cell-derived retinal organoids10.1038/s41467-021-24781-72041-1723https://doaj.org/article/2af30f8f756c41dbaef2dbee861750792021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24781-7https://doaj.org/toc/2041-1723Retinoblastoma is a heritable pediatric cancer driven by mutations in RB1. Here, the authors demonstrate the first patient derived model of retinoblastoma using iPSCs from patients with germline mutations in RB1.Jackie L. NorrieAnjana NityanandamKaren LaiXiang ChenMatthew WilsonElizabeth StewartLyra GriffithsHongjian JinGang WuBrent OrrQuynh TranSariah AllenColleen ReillyXin ZhouJiakun ZhangKyle NewmanDianna JohnsonRachel BrennanMichael A. DyerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jackie L. Norrie
Anjana Nityanandam
Karen Lai
Xiang Chen
Matthew Wilson
Elizabeth Stewart
Lyra Griffiths
Hongjian Jin
Gang Wu
Brent Orr
Quynh Tran
Sariah Allen
Colleen Reilly
Xin Zhou
Jiakun Zhang
Kyle Newman
Dianna Johnson
Rachel Brennan
Michael A. Dyer
Retinoblastoma from human stem cell-derived retinal organoids
description Retinoblastoma is a heritable pediatric cancer driven by mutations in RB1. Here, the authors demonstrate the first patient derived model of retinoblastoma using iPSCs from patients with germline mutations in RB1.
format article
author Jackie L. Norrie
Anjana Nityanandam
Karen Lai
Xiang Chen
Matthew Wilson
Elizabeth Stewart
Lyra Griffiths
Hongjian Jin
Gang Wu
Brent Orr
Quynh Tran
Sariah Allen
Colleen Reilly
Xin Zhou
Jiakun Zhang
Kyle Newman
Dianna Johnson
Rachel Brennan
Michael A. Dyer
author_facet Jackie L. Norrie
Anjana Nityanandam
Karen Lai
Xiang Chen
Matthew Wilson
Elizabeth Stewart
Lyra Griffiths
Hongjian Jin
Gang Wu
Brent Orr
Quynh Tran
Sariah Allen
Colleen Reilly
Xin Zhou
Jiakun Zhang
Kyle Newman
Dianna Johnson
Rachel Brennan
Michael A. Dyer
author_sort Jackie L. Norrie
title Retinoblastoma from human stem cell-derived retinal organoids
title_short Retinoblastoma from human stem cell-derived retinal organoids
title_full Retinoblastoma from human stem cell-derived retinal organoids
title_fullStr Retinoblastoma from human stem cell-derived retinal organoids
title_full_unstemmed Retinoblastoma from human stem cell-derived retinal organoids
title_sort retinoblastoma from human stem cell-derived retinal organoids
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2af30f8f756c41dbaef2dbee86175079
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