Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta.

Males and females responses to gestational overnutrition set the stage for subsequent sex-specific differences in adult onset non communicable diseases. Placenta, as a widely recognized programming agent, contibutes to the underlying processes. According to our previous findings, a high-fat diet dur...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Anne Gabory, Laure Ferry, Isabelle Fajardy, Luc Jouneau, Jean-David Gothié, Alexandre Vigé, Cécile Fleur, Sylvain Mayeur, Catherine Gallou-Kabani, Marie-Sylvie Gross, Linda Attig, Anne Vambergue, Jean Lesage, Brigitte Reusens, Didier Vieau, Claude Remacle, Jean-Philippe Jais, Claudine Junien
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
R
Q
Acceso en línea:https://doaj.org/article/2af5a4606b944a249a94a2e3db3bb27b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:2af5a4606b944a249a94a2e3db3bb27b
record_format dspace
spelling oai:doaj.org-article:2af5a4606b944a249a94a2e3db3bb27b2021-11-18T08:10:00ZMaternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta.1932-620310.1371/journal.pone.0047986https://doaj.org/article/2af5a4606b944a249a94a2e3db3bb27b2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23144842/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Males and females responses to gestational overnutrition set the stage for subsequent sex-specific differences in adult onset non communicable diseases. Placenta, as a widely recognized programming agent, contibutes to the underlying processes. According to our previous findings, a high-fat diet during gestation triggers sex-specific epigenetic alterations within CpG and throughout the genome, together with the deregulation of clusters of imprinted genes. We further investigated the impact of diet and sex on placental histology, transcriptomic and epigenetic signatures in mice. Both basal gene expression and response to maternal high-fat diet were sexually dimorphic in whole placentas. Numerous genes showed sexually dimorphic expression, but only 11 genes regardless of the diet. In line with the key role of genes belonging to the sex chromosomes, 3 of these genes were Y-specific and 3 were X-specific. Amongst all the genes that were differentially expressed under a high-fat diet, only 16 genes were consistently affected in both males and females. The differences were not only quantitative but remarkably qualitative. The biological functions and networks of genes dysregulated differed markedly between the sexes. Seven genes of the epigenetic machinery were dysregulated, due to effects of diet, sex or both, including the Y- and X-linked histone demethylase paralogues Kdm5c and Kdm5d, which could mark differently male and female epigenomes. The DNA methyltransferase cofactor Dnmt3l gene expression was affected, reminiscent of our previous observation of changes in global DNA methylation. Overall, this striking sexual dimorphism of programming trajectories impose a considerable revision of the current dietary interventions protocols.Anne GaboryLaure FerryIsabelle FajardyLuc JouneauJean-David GothiéAlexandre VigéCécile FleurSylvain MayeurCatherine Gallou-KabaniMarie-Sylvie GrossLinda AttigAnne VambergueJean LesageBrigitte ReusensDidier VieauClaude RemacleJean-Philippe JaisClaudine JunienPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e47986 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Anne Gabory
Laure Ferry
Isabelle Fajardy
Luc Jouneau
Jean-David Gothié
Alexandre Vigé
Cécile Fleur
Sylvain Mayeur
Catherine Gallou-Kabani
Marie-Sylvie Gross
Linda Attig
Anne Vambergue
Jean Lesage
Brigitte Reusens
Didier Vieau
Claude Remacle
Jean-Philippe Jais
Claudine Junien
Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta.
description Males and females responses to gestational overnutrition set the stage for subsequent sex-specific differences in adult onset non communicable diseases. Placenta, as a widely recognized programming agent, contibutes to the underlying processes. According to our previous findings, a high-fat diet during gestation triggers sex-specific epigenetic alterations within CpG and throughout the genome, together with the deregulation of clusters of imprinted genes. We further investigated the impact of diet and sex on placental histology, transcriptomic and epigenetic signatures in mice. Both basal gene expression and response to maternal high-fat diet were sexually dimorphic in whole placentas. Numerous genes showed sexually dimorphic expression, but only 11 genes regardless of the diet. In line with the key role of genes belonging to the sex chromosomes, 3 of these genes were Y-specific and 3 were X-specific. Amongst all the genes that were differentially expressed under a high-fat diet, only 16 genes were consistently affected in both males and females. The differences were not only quantitative but remarkably qualitative. The biological functions and networks of genes dysregulated differed markedly between the sexes. Seven genes of the epigenetic machinery were dysregulated, due to effects of diet, sex or both, including the Y- and X-linked histone demethylase paralogues Kdm5c and Kdm5d, which could mark differently male and female epigenomes. The DNA methyltransferase cofactor Dnmt3l gene expression was affected, reminiscent of our previous observation of changes in global DNA methylation. Overall, this striking sexual dimorphism of programming trajectories impose a considerable revision of the current dietary interventions protocols.
format article
author Anne Gabory
Laure Ferry
Isabelle Fajardy
Luc Jouneau
Jean-David Gothié
Alexandre Vigé
Cécile Fleur
Sylvain Mayeur
Catherine Gallou-Kabani
Marie-Sylvie Gross
Linda Attig
Anne Vambergue
Jean Lesage
Brigitte Reusens
Didier Vieau
Claude Remacle
Jean-Philippe Jais
Claudine Junien
author_facet Anne Gabory
Laure Ferry
Isabelle Fajardy
Luc Jouneau
Jean-David Gothié
Alexandre Vigé
Cécile Fleur
Sylvain Mayeur
Catherine Gallou-Kabani
Marie-Sylvie Gross
Linda Attig
Anne Vambergue
Jean Lesage
Brigitte Reusens
Didier Vieau
Claude Remacle
Jean-Philippe Jais
Claudine Junien
author_sort Anne Gabory
title Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta.
title_short Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta.
title_full Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta.
title_fullStr Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta.
title_full_unstemmed Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta.
title_sort maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta.
publisher Public Library of Science (PLoS)
publishDate 2012
url https://doaj.org/article/2af5a4606b944a249a94a2e3db3bb27b
work_keys_str_mv AT annegabory maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta
AT laureferry maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta
AT isabellefajardy maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta
AT lucjouneau maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta
AT jeandavidgothie maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta
AT alexandrevige maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta
AT cecilefleur maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta
AT sylvainmayeur maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta
AT catherinegalloukabani maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta
AT mariesylviegross maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta
AT lindaattig maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta
AT annevambergue maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta
AT jeanlesage maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta
AT brigittereusens maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta
AT didiervieau maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta
AT clauderemacle maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta
AT jeanphilippejais maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta
AT claudinejunien maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta
_version_ 1718422096385671168