Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta.
Males and females responses to gestational overnutrition set the stage for subsequent sex-specific differences in adult onset non communicable diseases. Placenta, as a widely recognized programming agent, contibutes to the underlying processes. According to our previous findings, a high-fat diet dur...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2012
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/2af5a4606b944a249a94a2e3db3bb27b |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:2af5a4606b944a249a94a2e3db3bb27b |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:2af5a4606b944a249a94a2e3db3bb27b2021-11-18T08:10:00ZMaternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta.1932-620310.1371/journal.pone.0047986https://doaj.org/article/2af5a4606b944a249a94a2e3db3bb27b2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23144842/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Males and females responses to gestational overnutrition set the stage for subsequent sex-specific differences in adult onset non communicable diseases. Placenta, as a widely recognized programming agent, contibutes to the underlying processes. According to our previous findings, a high-fat diet during gestation triggers sex-specific epigenetic alterations within CpG and throughout the genome, together with the deregulation of clusters of imprinted genes. We further investigated the impact of diet and sex on placental histology, transcriptomic and epigenetic signatures in mice. Both basal gene expression and response to maternal high-fat diet were sexually dimorphic in whole placentas. Numerous genes showed sexually dimorphic expression, but only 11 genes regardless of the diet. In line with the key role of genes belonging to the sex chromosomes, 3 of these genes were Y-specific and 3 were X-specific. Amongst all the genes that were differentially expressed under a high-fat diet, only 16 genes were consistently affected in both males and females. The differences were not only quantitative but remarkably qualitative. The biological functions and networks of genes dysregulated differed markedly between the sexes. Seven genes of the epigenetic machinery were dysregulated, due to effects of diet, sex or both, including the Y- and X-linked histone demethylase paralogues Kdm5c and Kdm5d, which could mark differently male and female epigenomes. The DNA methyltransferase cofactor Dnmt3l gene expression was affected, reminiscent of our previous observation of changes in global DNA methylation. Overall, this striking sexual dimorphism of programming trajectories impose a considerable revision of the current dietary interventions protocols.Anne GaboryLaure FerryIsabelle FajardyLuc JouneauJean-David GothiéAlexandre VigéCécile FleurSylvain MayeurCatherine Gallou-KabaniMarie-Sylvie GrossLinda AttigAnne VambergueJean LesageBrigitte ReusensDidier VieauClaude RemacleJean-Philippe JaisClaudine JunienPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e47986 (2012) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Anne Gabory Laure Ferry Isabelle Fajardy Luc Jouneau Jean-David Gothié Alexandre Vigé Cécile Fleur Sylvain Mayeur Catherine Gallou-Kabani Marie-Sylvie Gross Linda Attig Anne Vambergue Jean Lesage Brigitte Reusens Didier Vieau Claude Remacle Jean-Philippe Jais Claudine Junien Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta. |
| description |
Males and females responses to gestational overnutrition set the stage for subsequent sex-specific differences in adult onset non communicable diseases. Placenta, as a widely recognized programming agent, contibutes to the underlying processes. According to our previous findings, a high-fat diet during gestation triggers sex-specific epigenetic alterations within CpG and throughout the genome, together with the deregulation of clusters of imprinted genes. We further investigated the impact of diet and sex on placental histology, transcriptomic and epigenetic signatures in mice. Both basal gene expression and response to maternal high-fat diet were sexually dimorphic in whole placentas. Numerous genes showed sexually dimorphic expression, but only 11 genes regardless of the diet. In line with the key role of genes belonging to the sex chromosomes, 3 of these genes were Y-specific and 3 were X-specific. Amongst all the genes that were differentially expressed under a high-fat diet, only 16 genes were consistently affected in both males and females. The differences were not only quantitative but remarkably qualitative. The biological functions and networks of genes dysregulated differed markedly between the sexes. Seven genes of the epigenetic machinery were dysregulated, due to effects of diet, sex or both, including the Y- and X-linked histone demethylase paralogues Kdm5c and Kdm5d, which could mark differently male and female epigenomes. The DNA methyltransferase cofactor Dnmt3l gene expression was affected, reminiscent of our previous observation of changes in global DNA methylation. Overall, this striking sexual dimorphism of programming trajectories impose a considerable revision of the current dietary interventions protocols. |
| format |
article |
| author |
Anne Gabory Laure Ferry Isabelle Fajardy Luc Jouneau Jean-David Gothié Alexandre Vigé Cécile Fleur Sylvain Mayeur Catherine Gallou-Kabani Marie-Sylvie Gross Linda Attig Anne Vambergue Jean Lesage Brigitte Reusens Didier Vieau Claude Remacle Jean-Philippe Jais Claudine Junien |
| author_facet |
Anne Gabory Laure Ferry Isabelle Fajardy Luc Jouneau Jean-David Gothié Alexandre Vigé Cécile Fleur Sylvain Mayeur Catherine Gallou-Kabani Marie-Sylvie Gross Linda Attig Anne Vambergue Jean Lesage Brigitte Reusens Didier Vieau Claude Remacle Jean-Philippe Jais Claudine Junien |
| author_sort |
Anne Gabory |
| title |
Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta. |
| title_short |
Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta. |
| title_full |
Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta. |
| title_fullStr |
Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta. |
| title_full_unstemmed |
Maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta. |
| title_sort |
maternal diets trigger sex-specific divergent trajectories of gene expression and epigenetic systems in mouse placenta. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/2af5a4606b944a249a94a2e3db3bb27b |
| work_keys_str_mv |
AT annegabory maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta AT laureferry maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta AT isabellefajardy maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta AT lucjouneau maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta AT jeandavidgothie maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta AT alexandrevige maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta AT cecilefleur maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta AT sylvainmayeur maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta AT catherinegalloukabani maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta AT mariesylviegross maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta AT lindaattig maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta AT annevambergue maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta AT jeanlesage maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta AT brigittereusens maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta AT didiervieau maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta AT clauderemacle maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta AT jeanphilippejais maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta AT claudinejunien maternaldietstriggersexspecificdivergenttrajectoriesofgeneexpressionandepigeneticsystemsinmouseplacenta |
| _version_ |
1718422096385671168 |