Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog.

Morphogens are secreted signalling molecules that act in a graded manner to control the pattern of cellular differentiation in developing tissues. An example is Sonic hedgehog (Shh), which acts in several developing vertebrate tissues, including the central nervous system, to provide positional info...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eric Dessaud, Vanessa Ribes, Nikolaos Balaskas, Lin Lin Yang, Alessandra Pierani, Anna Kicheva, Bennett G Novitch, James Briscoe, Noriaki Sasai
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2aff196356d5450b80e38bb51ec9e56e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2aff196356d5450b80e38bb51ec9e56e
record_format	dspace
spelling	oai:doaj.org-article:2aff196356d5450b80e38bb51ec9e56e2021-12-02T19:54:49ZDynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog.1544-91731545-788510.1371/journal.pbio.1000382https://doaj.org/article/2aff196356d5450b80e38bb51ec9e56e2010-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20532235/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Morphogens are secreted signalling molecules that act in a graded manner to control the pattern of cellular differentiation in developing tissues. An example is Sonic hedgehog (Shh), which acts in several developing vertebrate tissues, including the central nervous system, to provide positional information during embryonic patterning. Here we address how Shh signalling assigns the positional identities of distinct neuronal subtype progenitors throughout the ventral neural tube. Assays of intracellular signal transduction and gene expression indicate that the duration as well as level of signalling is critical for morphogen interpretation. Progenitors of the ventral neuronal subtypes are established sequentially, with progressively more ventral identities requiring correspondingly higher levels and longer periods of Shh signalling. Moreover, cells remain sensitive to changes in Shh signalling for an extended time, reverting to antecedent identities if signalling levels fall below a threshold. Thus, the duration of signalling is important not only for the assignment but also for the refinement and maintenance of positional identity. Together the data suggest a dynamic model for ventral neural tube patterning in which positional information corresponds to the time integral of Shh signalling. This suggests an alternative to conventional models of morphogen action that rely solely on the level of signalling.Eric DessaudVanessa RibesNikolaos BalaskasLin Lin YangAlessandra PieraniAnna KichevaBennett G NovitchJames BriscoeNoriaki SasaiPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 8, Iss 6, p e1000382 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Eric Dessaud Vanessa Ribes Nikolaos Balaskas Lin Lin Yang Alessandra Pierani Anna Kicheva Bennett G Novitch James Briscoe Noriaki Sasai Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog.
description	Morphogens are secreted signalling molecules that act in a graded manner to control the pattern of cellular differentiation in developing tissues. An example is Sonic hedgehog (Shh), which acts in several developing vertebrate tissues, including the central nervous system, to provide positional information during embryonic patterning. Here we address how Shh signalling assigns the positional identities of distinct neuronal subtype progenitors throughout the ventral neural tube. Assays of intracellular signal transduction and gene expression indicate that the duration as well as level of signalling is critical for morphogen interpretation. Progenitors of the ventral neuronal subtypes are established sequentially, with progressively more ventral identities requiring correspondingly higher levels and longer periods of Shh signalling. Moreover, cells remain sensitive to changes in Shh signalling for an extended time, reverting to antecedent identities if signalling levels fall below a threshold. Thus, the duration of signalling is important not only for the assignment but also for the refinement and maintenance of positional identity. Together the data suggest a dynamic model for ventral neural tube patterning in which positional information corresponds to the time integral of Shh signalling. This suggests an alternative to conventional models of morphogen action that rely solely on the level of signalling.
format	article
author	Eric Dessaud Vanessa Ribes Nikolaos Balaskas Lin Lin Yang Alessandra Pierani Anna Kicheva Bennett G Novitch James Briscoe Noriaki Sasai
author_facet	Eric Dessaud Vanessa Ribes Nikolaos Balaskas Lin Lin Yang Alessandra Pierani Anna Kicheva Bennett G Novitch James Briscoe Noriaki Sasai
author_sort	Eric Dessaud
title	Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog.
title_short	Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog.
title_full	Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog.
title_fullStr	Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog.
title_full_unstemmed	Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog.
title_sort	dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/2aff196356d5450b80e38bb51ec9e56e
work_keys_str_mv	AT ericdessaud dynamicassignmentandmaintenanceofpositionalidentityintheventralneuraltubebythemorphogensonichedgehog AT vanessaribes dynamicassignmentandmaintenanceofpositionalidentityintheventralneuraltubebythemorphogensonichedgehog AT nikolaosbalaskas dynamicassignmentandmaintenanceofpositionalidentityintheventralneuraltubebythemorphogensonichedgehog AT linlinyang dynamicassignmentandmaintenanceofpositionalidentityintheventralneuraltubebythemorphogensonichedgehog AT alessandrapierani dynamicassignmentandmaintenanceofpositionalidentityintheventralneuraltubebythemorphogensonichedgehog AT annakicheva dynamicassignmentandmaintenanceofpositionalidentityintheventralneuraltubebythemorphogensonichedgehog AT bennettgnovitch dynamicassignmentandmaintenanceofpositionalidentityintheventralneuraltubebythemorphogensonichedgehog AT jamesbriscoe dynamicassignmentandmaintenanceofpositionalidentityintheventralneuraltubebythemorphogensonichedgehog AT noriakisasai dynamicassignmentandmaintenanceofpositionalidentityintheventralneuraltubebythemorphogensonichedgehog
_version_	1718375830123446272

Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog.

Ejemplares similares