Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors

Heteroatom-rich organoboron compounds are promising modulators of enzyme activity. Here, the authors report a library of aminocyanoboronates as serine hydrolases inhibitors with the most potent compound showing in vivo and in vitro nanomolar activity and high selectivity towards human ABHD3 hydrolas...

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Autores principales:	Joanne Tan, Armand B. Cognetta III, Diego B. Diaz, Kenneth M. Lum, Shinya Adachi, Soumajit Kundu, Benjamin F. Cravatt, Andrei K. Yudin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2aff97f7effa472ca74895e649dd461a
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spelling	oai:doaj.org-article:2aff97f7effa472ca74895e649dd461a2021-12-02T15:38:58ZMulticomponent mapping of boron chemotypes furnishes selective enzyme inhibitors10.1038/s41467-017-01319-42041-1723https://doaj.org/article/2aff97f7effa472ca74895e649dd461a2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01319-4https://doaj.org/toc/2041-1723Heteroatom-rich organoboron compounds are promising modulators of enzyme activity. Here, the authors report a library of aminocyanoboronates as serine hydrolases inhibitors with the most potent compound showing in vivo and in vitro nanomolar activity and high selectivity towards human ABHD3 hydrolase.Joanne TanArmand B. Cognetta IIIDiego B. DiazKenneth M. LumShinya AdachiSoumajit KunduBenjamin F. CravattAndrei K. YudinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joanne Tan Armand B. Cognetta III Diego B. Diaz Kenneth M. Lum Shinya Adachi Soumajit Kundu Benjamin F. Cravatt Andrei K. Yudin Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors
description	Heteroatom-rich organoboron compounds are promising modulators of enzyme activity. Here, the authors report a library of aminocyanoboronates as serine hydrolases inhibitors with the most potent compound showing in vivo and in vitro nanomolar activity and high selectivity towards human ABHD3 hydrolase.
format	article
author	Joanne Tan Armand B. Cognetta III Diego B. Diaz Kenneth M. Lum Shinya Adachi Soumajit Kundu Benjamin F. Cravatt Andrei K. Yudin
author_facet	Joanne Tan Armand B. Cognetta III Diego B. Diaz Kenneth M. Lum Shinya Adachi Soumajit Kundu Benjamin F. Cravatt Andrei K. Yudin
author_sort	Joanne Tan
title	Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors
title_short	Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors
title_full	Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors
title_fullStr	Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors
title_full_unstemmed	Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors
title_sort	multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2aff97f7effa472ca74895e649dd461a
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Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors

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