Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression

Abstract Circular RNAs (circRNAs), covalently closed noncoding RNAs, are widely expressed in eukaryotes and viruses. They can function by regulating target gene expression, linear RNA transcription and protein generation. The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays key roles in...

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Autores principales:	Chen Xue, Ganglei Li, Juan Lu, Lanjuan Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Medicine R Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2b0134d131c7418d988ac59477f451eb
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spelling	oai:doaj.org-article:2b0134d131c7418d988ac59477f451eb2021-11-28T12:08:44ZCrosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression10.1038/s41392-021-00788-w2059-3635https://doaj.org/article/2b0134d131c7418d988ac59477f451eb2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41392-021-00788-whttps://doaj.org/toc/2059-3635Abstract Circular RNAs (circRNAs), covalently closed noncoding RNAs, are widely expressed in eukaryotes and viruses. They can function by regulating target gene expression, linear RNA transcription and protein generation. The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays key roles in many biological and cellular processes, such as cell proliferation, growth, invasion, migration, and angiogenesis. It also plays a pivotal role in cancer progression. Emerging data suggest that the circRNA/PI3K/AKT axis modulates the expression of cancer-associated genes and thus regulates tumor progression. Aberrant regulation of the expression of circRNAs in the circRNA/PI3K/AKT axis is significantly associated with clinicopathological characteristics and plays an important role in the regulation of biological functions. In this review, we summarized the expression and biological functions of PI3K-AKT-related circRNAs in vitro and in vivo and assessed their associations with clinicopathological characteristics. We also further discussed the important role of circRNAs in the diagnosis, prognostication, and treatment of cancers.Chen XueGanglei LiJuan LuLanjuan LiNature Publishing GrouparticleMedicineRBiology (General)QH301-705.5ENSignal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Biology (General) QH301-705.5
spellingShingle	Medicine R Biology (General) QH301-705.5 Chen Xue Ganglei Li Juan Lu Lanjuan Li Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression
description	Abstract Circular RNAs (circRNAs), covalently closed noncoding RNAs, are widely expressed in eukaryotes and viruses. They can function by regulating target gene expression, linear RNA transcription and protein generation. The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays key roles in many biological and cellular processes, such as cell proliferation, growth, invasion, migration, and angiogenesis. It also plays a pivotal role in cancer progression. Emerging data suggest that the circRNA/PI3K/AKT axis modulates the expression of cancer-associated genes and thus regulates tumor progression. Aberrant regulation of the expression of circRNAs in the circRNA/PI3K/AKT axis is significantly associated with clinicopathological characteristics and plays an important role in the regulation of biological functions. In this review, we summarized the expression and biological functions of PI3K-AKT-related circRNAs in vitro and in vivo and assessed their associations with clinicopathological characteristics. We also further discussed the important role of circRNAs in the diagnosis, prognostication, and treatment of cancers.
format	article
author	Chen Xue Ganglei Li Juan Lu Lanjuan Li
author_facet	Chen Xue Ganglei Li Juan Lu Lanjuan Li
author_sort	Chen Xue
title	Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression
title_short	Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression
title_full	Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression
title_fullStr	Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression
title_full_unstemmed	Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression
title_sort	crosstalk between circrnas and the pi3k/akt signaling pathway in cancer progression
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/2b0134d131c7418d988ac59477f451eb
work_keys_str_mv	AT chenxue crosstalkbetweencircrnasandthepi3kaktsignalingpathwayincancerprogression AT gangleili crosstalkbetweencircrnasandthepi3kaktsignalingpathwayincancerprogression AT juanlu crosstalkbetweencircrnasandthepi3kaktsignalingpathwayincancerprogression AT lanjuanli crosstalkbetweencircrnasandthepi3kaktsignalingpathwayincancerprogression
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Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression

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