Ub-ProT reveals global length and composition of protein ubiquitylation in cells

Ubiquitylation is a dynamic post-translational modification involved in the regulation of numerous cellular processes. Here the authors describe Ub-ProT: a method to measure the length of substrate-attached ubiquitin chains in biological samples, and demonstrate a critical role for chain length in d...

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Autores principales:	Hikaru Tsuchiya, Daocharad Burana, Fumiaki Ohtake, Naoko Arai, Ai Kaiho, Masayuki Komada, Keiji Tanaka, Yasushi Saeki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2b014eb25d6c43bab969807300ebe60e
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spelling	oai:doaj.org-article:2b014eb25d6c43bab969807300ebe60e2021-12-02T14:39:47ZUb-ProT reveals global length and composition of protein ubiquitylation in cells10.1038/s41467-018-02869-x2041-1723https://doaj.org/article/2b014eb25d6c43bab969807300ebe60e2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02869-xhttps://doaj.org/toc/2041-1723Ubiquitylation is a dynamic post-translational modification involved in the regulation of numerous cellular processes. Here the authors describe Ub-ProT: a method to measure the length of substrate-attached ubiquitin chains in biological samples, and demonstrate a critical role for chain length in directing substrates to specific cellular pathways.Hikaru TsuchiyaDaocharad BuranaFumiaki OhtakeNaoko AraiAi KaihoMasayuki KomadaKeiji TanakaYasushi SaekiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hikaru Tsuchiya Daocharad Burana Fumiaki Ohtake Naoko Arai Ai Kaiho Masayuki Komada Keiji Tanaka Yasushi Saeki Ub-ProT reveals global length and composition of protein ubiquitylation in cells
description	Ubiquitylation is a dynamic post-translational modification involved in the regulation of numerous cellular processes. Here the authors describe Ub-ProT: a method to measure the length of substrate-attached ubiquitin chains in biological samples, and demonstrate a critical role for chain length in directing substrates to specific cellular pathways.
format	article
author	Hikaru Tsuchiya Daocharad Burana Fumiaki Ohtake Naoko Arai Ai Kaiho Masayuki Komada Keiji Tanaka Yasushi Saeki
author_facet	Hikaru Tsuchiya Daocharad Burana Fumiaki Ohtake Naoko Arai Ai Kaiho Masayuki Komada Keiji Tanaka Yasushi Saeki
author_sort	Hikaru Tsuchiya
title	Ub-ProT reveals global length and composition of protein ubiquitylation in cells
title_short	Ub-ProT reveals global length and composition of protein ubiquitylation in cells
title_full	Ub-ProT reveals global length and composition of protein ubiquitylation in cells
title_fullStr	Ub-ProT reveals global length and composition of protein ubiquitylation in cells
title_full_unstemmed	Ub-ProT reveals global length and composition of protein ubiquitylation in cells
title_sort	ub-prot reveals global length and composition of protein ubiquitylation in cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2b014eb25d6c43bab969807300ebe60e
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Ub-ProT reveals global length and composition of protein ubiquitylation in cells

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