Roles of LncRNAs in Regulating Mitochondrial Dysfunction in Septic Cardiomyopathy

Sepsis is an abnormal systemic inflammatory response of the host immune system to infection and can lead to fatal multiorgan dysfunction syndrome. Epidemiological studies have shown that approximately 10-70% of sepsis cases can lead to septic cardiomyopathy. Since the pathogenesis of septic cardiomy...

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Autores principales:	Shuang Liu, Wei Chong
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	lncRNA epigenetics sepsis septic cardiomyopathy mitochondrial dysfunction Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/2b01531f80c044e78e5ed68dfadaa1a2
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spelling	oai:doaj.org-article:2b01531f80c044e78e5ed68dfadaa1a22021-11-30T19:00:51ZRoles of LncRNAs in Regulating Mitochondrial Dysfunction in Septic Cardiomyopathy1664-322410.3389/fimmu.2021.802085https://doaj.org/article/2b01531f80c044e78e5ed68dfadaa1a22021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.802085/fullhttps://doaj.org/toc/1664-3224Sepsis is an abnormal systemic inflammatory response of the host immune system to infection and can lead to fatal multiorgan dysfunction syndrome. Epidemiological studies have shown that approximately 10-70% of sepsis cases can lead to septic cardiomyopathy. Since the pathogenesis of septic cardiomyopathy is not clear, it is difficult for medical doctors to treat the disease. Therefore, finding effective interventions to prevent and reduce myocardial damage in septic cardiomyopathy is clinically significant. Epigenetics is the study of stable genetic phenotype inheritance that does not involve changing gene sequences. Epigenetic inheritance is affected by both gene and environmental regulation. Epigenetic studies focus on the modification and influence of chromatin structure, mainly including chromatin remodelling, DNA methylation, histone modification and noncoding RNA (ncRNA)-related mechanisms. Recently, long ncRNA (lncRNA)-related mechanisms have been the focus of epigenetic studies. LncRNAs are expected to become important targets to prevent, diagnose and treat human diseases. As the energy metabolism centre of cells, mitochondria are important targets in septic cardiomyopathy. Intervention measures to prevent and treat mitochondrial damage are of great significance for improving the prognosis of septic cardiomyopathy. LncRNAs play important roles in life activities. Recently, studies have focused on the involvement of lncRNAs in regulating mitochondrial dysfunction. However, few studies have revealed the involvement of lncRNAs in regulating mitochondrial dysfunction in septic cardiomyopathy. In this article, we briefly review recent research in this area.Shuang LiuWei ChongFrontiers Media S.A.articlelncRNAepigeneticssepsisseptic cardiomyopathymitochondrial dysfunctionImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lncRNA epigenetics sepsis septic cardiomyopathy mitochondrial dysfunction Immunologic diseases. Allergy RC581-607
spellingShingle	lncRNA epigenetics sepsis septic cardiomyopathy mitochondrial dysfunction Immunologic diseases. Allergy RC581-607 Shuang Liu Wei Chong Roles of LncRNAs in Regulating Mitochondrial Dysfunction in Septic Cardiomyopathy
description	Sepsis is an abnormal systemic inflammatory response of the host immune system to infection and can lead to fatal multiorgan dysfunction syndrome. Epidemiological studies have shown that approximately 10-70% of sepsis cases can lead to septic cardiomyopathy. Since the pathogenesis of septic cardiomyopathy is not clear, it is difficult for medical doctors to treat the disease. Therefore, finding effective interventions to prevent and reduce myocardial damage in septic cardiomyopathy is clinically significant. Epigenetics is the study of stable genetic phenotype inheritance that does not involve changing gene sequences. Epigenetic inheritance is affected by both gene and environmental regulation. Epigenetic studies focus on the modification and influence of chromatin structure, mainly including chromatin remodelling, DNA methylation, histone modification and noncoding RNA (ncRNA)-related mechanisms. Recently, long ncRNA (lncRNA)-related mechanisms have been the focus of epigenetic studies. LncRNAs are expected to become important targets to prevent, diagnose and treat human diseases. As the energy metabolism centre of cells, mitochondria are important targets in septic cardiomyopathy. Intervention measures to prevent and treat mitochondrial damage are of great significance for improving the prognosis of septic cardiomyopathy. LncRNAs play important roles in life activities. Recently, studies have focused on the involvement of lncRNAs in regulating mitochondrial dysfunction. However, few studies have revealed the involvement of lncRNAs in regulating mitochondrial dysfunction in septic cardiomyopathy. In this article, we briefly review recent research in this area.
format	article
author	Shuang Liu Wei Chong
author_facet	Shuang Liu Wei Chong
author_sort	Shuang Liu
title	Roles of LncRNAs in Regulating Mitochondrial Dysfunction in Septic Cardiomyopathy
title_short	Roles of LncRNAs in Regulating Mitochondrial Dysfunction in Septic Cardiomyopathy
title_full	Roles of LncRNAs in Regulating Mitochondrial Dysfunction in Septic Cardiomyopathy
title_fullStr	Roles of LncRNAs in Regulating Mitochondrial Dysfunction in Septic Cardiomyopathy
title_full_unstemmed	Roles of LncRNAs in Regulating Mitochondrial Dysfunction in Septic Cardiomyopathy
title_sort	roles of lncrnas in regulating mitochondrial dysfunction in septic cardiomyopathy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2b01531f80c044e78e5ed68dfadaa1a2
work_keys_str_mv	AT shuangliu rolesoflncrnasinregulatingmitochondrialdysfunctioninsepticcardiomyopathy AT weichong rolesoflncrnasinregulatingmitochondrialdysfunctioninsepticcardiomyopathy
_version_	1718406312569602048

Roles of LncRNAs in Regulating Mitochondrial Dysfunction in Septic Cardiomyopathy

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