Differentiation of Acquired Immune Deficiency Syndrome Related Primary Central Nervous System Lymphoma from Cerebral toxoplasmosis with Use of Susceptibility-Weighted Imaging and Contrast Enhanced 3D-T1WI

Background: We aimed to investigate whether susceptibility-weighted imaging (SWI) and contrast-enhanced 3D-T1WI can differentiate Acquired Immune Deficiency Syndrome-Related Primary Central Nervous System Lymphoma (AR-PCNSL) from cerebral toxoplasmosis. Methods: This was a prospective cohort study....

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Autores principales:	Jingjing Li, Ming Xue, Zhibin Lv, Chunshuang Guan, Shunxing Huang, Shuo Li, Bo Liang, Xingang Zhou, Budong Chen, Ruming Xie
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Lymphoma AIDS-Related Central Nervous System Magnetic Resonance Imaging Susceptibility-Weighted Imaging Cerebral toxoplasmosis Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/2b06687dcbe1479291b6b331a9a2c432
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spelling	oai:doaj.org-article:2b06687dcbe1479291b6b331a9a2c4322021-11-14T04:31:15ZDifferentiation of Acquired Immune Deficiency Syndrome Related Primary Central Nervous System Lymphoma from Cerebral toxoplasmosis with Use of Susceptibility-Weighted Imaging and Contrast Enhanced 3D-T1WI1201-971210.1016/j.ijid.2021.10.023https://doaj.org/article/2b06687dcbe1479291b6b331a9a2c4322021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221008134https://doaj.org/toc/1201-9712Background: We aimed to investigate whether susceptibility-weighted imaging (SWI) and contrast-enhanced 3D-T1WI can differentiate Acquired Immune Deficiency Syndrome-Related Primary Central Nervous System Lymphoma (AR-PCNSL) from cerebral toxoplasmosis. Methods: This was a prospective cohort study. 20 AIDS patients were divided into AR-PCNSL group (13 cases) and cerebral toxoplasmosis group (7 cases) based on pathology results. We analyzed the appearance of lesions on SWI and enhanced 3D T1WI and ROC curves in the diagnosis of AR-PCNSL and cerebral toxoplasmosis. Results: Cerebral toxoplasmosis was more likely to show annular enhancement (p = 0.002) and complete smooth ring enhancement (p = 0.002). It was also more likely to present a complete, smooth low signal intensity rim (LSIR) (p = 0.002) and an incomplete, smooth LSIR (p = 0.019) on SWI. AR-PCNSL was more likely to present an incomplete, irregular LSIR (p < 0.001) and irregular central low signal intensity (CLSI) (p<0.001) on SWI. The areas under the ROC curve of the SWI-ILSS grade and enhanced volume on 3D-T1WI were 0.872 and 0.862, respectively. Conclusion: A higher SWI-ILSS grade and larger 3D-T1WI volume enhancement were diagnostic for AR-PCNSL. SWI and CE 3D-T1WI were useful in the differential diagnosis of AR-PCNSL and cerebral toxoplasmosis.Jingjing LiMing XueZhibin LvChunshuang GuanShunxing HuangShuo LiBo LiangXingang ZhouBudong ChenRuming XieElsevierarticleLymphomaAIDS-RelatedCentral Nervous SystemMagnetic Resonance ImagingSusceptibility-Weighted ImagingCerebral toxoplasmosisInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 113, Iss , Pp 251-258 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lymphoma AIDS-Related Central Nervous System Magnetic Resonance Imaging Susceptibility-Weighted Imaging Cerebral toxoplasmosis Infectious and parasitic diseases RC109-216
spellingShingle	Lymphoma AIDS-Related Central Nervous System Magnetic Resonance Imaging Susceptibility-Weighted Imaging Cerebral toxoplasmosis Infectious and parasitic diseases RC109-216 Jingjing Li Ming Xue Zhibin Lv Chunshuang Guan Shunxing Huang Shuo Li Bo Liang Xingang Zhou Budong Chen Ruming Xie Differentiation of Acquired Immune Deficiency Syndrome Related Primary Central Nervous System Lymphoma from Cerebral toxoplasmosis with Use of Susceptibility-Weighted Imaging and Contrast Enhanced 3D-T1WI
description	Background: We aimed to investigate whether susceptibility-weighted imaging (SWI) and contrast-enhanced 3D-T1WI can differentiate Acquired Immune Deficiency Syndrome-Related Primary Central Nervous System Lymphoma (AR-PCNSL) from cerebral toxoplasmosis. Methods: This was a prospective cohort study. 20 AIDS patients were divided into AR-PCNSL group (13 cases) and cerebral toxoplasmosis group (7 cases) based on pathology results. We analyzed the appearance of lesions on SWI and enhanced 3D T1WI and ROC curves in the diagnosis of AR-PCNSL and cerebral toxoplasmosis. Results: Cerebral toxoplasmosis was more likely to show annular enhancement (p = 0.002) and complete smooth ring enhancement (p = 0.002). It was also more likely to present a complete, smooth low signal intensity rim (LSIR) (p = 0.002) and an incomplete, smooth LSIR (p = 0.019) on SWI. AR-PCNSL was more likely to present an incomplete, irregular LSIR (p < 0.001) and irregular central low signal intensity (CLSI) (p<0.001) on SWI. The areas under the ROC curve of the SWI-ILSS grade and enhanced volume on 3D-T1WI were 0.872 and 0.862, respectively. Conclusion: A higher SWI-ILSS grade and larger 3D-T1WI volume enhancement were diagnostic for AR-PCNSL. SWI and CE 3D-T1WI were useful in the differential diagnosis of AR-PCNSL and cerebral toxoplasmosis.
format	article
author	Jingjing Li Ming Xue Zhibin Lv Chunshuang Guan Shunxing Huang Shuo Li Bo Liang Xingang Zhou Budong Chen Ruming Xie
author_facet	Jingjing Li Ming Xue Zhibin Lv Chunshuang Guan Shunxing Huang Shuo Li Bo Liang Xingang Zhou Budong Chen Ruming Xie
author_sort	Jingjing Li
title	Differentiation of Acquired Immune Deficiency Syndrome Related Primary Central Nervous System Lymphoma from Cerebral toxoplasmosis with Use of Susceptibility-Weighted Imaging and Contrast Enhanced 3D-T1WI
title_short	Differentiation of Acquired Immune Deficiency Syndrome Related Primary Central Nervous System Lymphoma from Cerebral toxoplasmosis with Use of Susceptibility-Weighted Imaging and Contrast Enhanced 3D-T1WI
title_full	Differentiation of Acquired Immune Deficiency Syndrome Related Primary Central Nervous System Lymphoma from Cerebral toxoplasmosis with Use of Susceptibility-Weighted Imaging and Contrast Enhanced 3D-T1WI
title_fullStr	Differentiation of Acquired Immune Deficiency Syndrome Related Primary Central Nervous System Lymphoma from Cerebral toxoplasmosis with Use of Susceptibility-Weighted Imaging and Contrast Enhanced 3D-T1WI
title_full_unstemmed	Differentiation of Acquired Immune Deficiency Syndrome Related Primary Central Nervous System Lymphoma from Cerebral toxoplasmosis with Use of Susceptibility-Weighted Imaging and Contrast Enhanced 3D-T1WI
title_sort	differentiation of acquired immune deficiency syndrome related primary central nervous system lymphoma from cerebral toxoplasmosis with use of susceptibility-weighted imaging and contrast enhanced 3d-t1wi
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/2b06687dcbe1479291b6b331a9a2c432
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Differentiation of Acquired Immune Deficiency Syndrome Related Primary Central Nervous System Lymphoma from Cerebral toxoplasmosis with Use of Susceptibility-Weighted Imaging and Contrast Enhanced 3D-T1WI

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